{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T23:40:39Z","timestamp":1788824439378,"version":"build-2803163510"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Relapsing\u2013remitting multiple sclerosis (RRMS) is characterized by unpredictable relapses that affect neurological and psychological functioning. Among psychosocial factors, fear of relapse (FoR) has been increasingly studied in relation to quality of life (QoL). This study examined the associations of FoR and health anxiety with QoL in RRMS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this cross-sectional study, 94 RRMS patients and 50 demographically comparable healthy controls were included. Participants completed the Expanded Disability Status Scale (EDSS), FoR Scale, Health Anxiety Inventory (HAI-18), and Short Form-36 (SF-36). Between-group comparisons were conducted for descriptive purposes. Correlation and hierarchical regression analyses were restricted to the RRMS group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with healthy controls, RRMS patients had higher health anxiety and lower physical and mental QoL scores (all\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001). Within the RRMS group, FoR was negatively correlated with physical (\n                      <jats:italic>r<\/jats:italic>\n                      \u202f=\u202f\u22120.537) and mental QoL (\n                      <jats:italic>r<\/jats:italic>\n                      \u202f=\u202f\u22120.481), while health anxiety showed stronger negative correlations (all\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001). In hierarchical regression analyses, demographic and clinical variables were not significantly associated with QoL. The inclusion of health anxiety and FoR increased explained variance to 50.4% for physical QoL and 46.8% for mental QoL. Both variables were significantly and negatively associated with QoL in final models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>FoR and health anxiety are significantly associated with QoL in RRMS. While health anxiety demonstrated comparatively stronger associations, FoR was also related to QoL beyond demographic and clinical variables, supporting the clinical relevance of both general and disease-specific anxiety processes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1770236","type":"journal-article","created":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T06:56:58Z","timestamp":1772693818000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["The role of fear of relapse in quality of life among patients with relapsing\u2013remitting multiple sclerosis"],"prefix":"10.3389","volume":"17","author":[{"given":"P\u0131nar","family":"\u00d6zt\u00fcrk","sequence":"first","affiliation":[{"name":"Department of Neurology, Yenimahalle Training and Research Hospital, Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University","place":["Ankara, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital","place":["Ankara, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.1177\/1352458520970841","article-title":"Rising prevalence of multiple sclerosis worldwide: insights from the atlas of MS, third edition","volume":"26","author":"Walton","year":"2020","journal-title":"Mult Scler"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1007\/s00415-018-8764-4","article-title":"The long-term impact of early treatment of multiple sclerosis on the risk of disability pension","volume":"265","author":"Landfeldt","year":"2018","journal-title":"J Neurol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1111\/ppc.12807","article-title":"The effect on the anxiety level of the social support given to multiple sclerosis patients","volume":"58","author":"Alt\u0131nkaynak Y\u0131lmaz","year":"2022","journal-title":"Perspect Psychiatr Care"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1053\/apmr.2002.36837","article-title":"Use of the SF-36 and other health-related quality of life measures to assess persons with disabilities","volume":"83","author":"Hays","year":"2002","journal-title":"Arch Phys Med Rehabil"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"105026","DOI":"10.1016\/j.msard.2023.105026","article-title":"Fear of relapse and quality of life in multiple sclerosis: the mediating role of psychological resilience","volume":"79","author":"Broche-P\u00e9rez","year":"2023","journal-title":"Mult Scler Relat Disord"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1191\/1352458506ms1296oa","article-title":"Relationship between stress and relapse in multiple sclerosis: part II. 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