{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T05:09:46Z","timestamp":1779167386200,"version":"3.51.4"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Post-stroke depression (PSD) is one of the most common neuropsychiatric complications among stroke survivors, with a substantial impact on functional recovery and quality of life. This study aimed to investigate the effect of flupentixol and melitracen tablets combined with repetitive transcranial magnetic stimulation (rTMS) on patients with post-stroke depression (PSD) and analyze the differences in the key factors of the 17-item Hamilton Depression Scale (HAMD\n                      <jats:sub>17<\/jats:sub>\n                      ) scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a retrospective analysis of 121 patients with PSD, including 57 patients who used the flupentixol and melitracen tablets alone and 64 patients who additionally received rTMS. General information was assessed. Follow-up indices after treatment included P300, National Institutes of Health Stroke Scale (NIHSS), HAMD\n                      <jats:sub>17<\/jats:sub>\n                      , and the Barthel Index (BI) and Pittsburgh Sleep Quality Index (PSQI) questionnaire. Observable mood (OM), cognitive symptoms (CS) and neurovegetative symptoms (NS), the three dimensions of HAMD\n                      <jats:sub>17<\/jats:sub>\n                      was also analyzed. The concentrations of 5-hydroxytryptamine (5-HT), norepinephrine (NE), neuropeptide Y (NPY) and brain-derived neurotrophic factor (BDNF) in the serum were measured during all time points.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was significant difference in the amplitude and latency of P300 and NS after 2\u202fweeks and 4\u202fweeks treatment between the groups, while there was significant difference in the concentrations of 5-HT, NE, NPY, BDNF and the scores of NIHSS, HAMD\n                      <jats:sub>17<\/jats:sub>\n                      , BI, PSQI after 4\u202fweeks treatment. The treatment outcomes at 4\u202fweeks demonstrated statistically significant differences compared to those observed at 2\u202fweeks both at control group and combination group. The results also indicated that the treatment in the combined group demonstrated superiority over that in the control group with respect to both onset time and therapeutic efficacy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Combination of flupentixol and melitracen tablets and rTMS could significantly improve the depressive symptoms of patients with PSD, NS was the symptom dimension most closely related to the therapeutic response. More importantly, the P300 parameter might provide an early and objective indicator of the neurophysiological changes associated with the treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1773502","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T04:21:24Z","timestamp":1779164484000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Combination of flupentixol and melitracen tablets and rTMS improves post-stroke depression through neurovegetative symptoms changes: a retrospective analysis"],"prefix":"10.3389","volume":"17","author":[{"given":"Haizhou","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology, The Affiliated Hospital of Xuzhou Medical University","place":["Xuzhou, Jiangsu, China"]},{"name":"First Clinical College of Xuzhou Medical University","place":["Xuzhou, Jiangsu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kejun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuzhou New Health Geriatric Hospital","place":["Xuzhou, Jiangsu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zikui","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuzhou New Health Geriatric Hospital","place":["Xuzhou, Jiangsu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaokai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuzhou New Health Geriatric Hospital","place":["Xuzhou, Jiangsu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanbo","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Hospital of Xuzhou Medical University","place":["Xuzhou, Jiangsu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1177\/17474930211065917","article-title":"Global stroke fact sheet 2022","volume":"17","author":"Feigin","year":"2022","journal-title":"Int J Stroke"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1547365","DOI":"10.3389\/fimmu.2025.1547365","article-title":"Post-stroke depression: exploring gut microbiota-mediated barrier dysfunction through immune regulation","volume":"16","author":"Jiang","year":"2025","journal-title":"Front Immunol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.genhosppsych.2017.04.001","article-title":"Prevalence and predictors of post-stroke mood disorders: a meta-analysis and meta-regression of depression, anxiety and adjustment disorder","volume":"47","author":"Mitchell","year":"2017","journal-title":"Gen 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