{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T07:34:47Z","timestamp":1774424087859,"version":"3.50.1"},"reference-count":12,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Anti\u2013neurofascin-155 (NF155) antibody-positive nodopathy is a distinct autoimmune neuropathy characterized by sensory ataxia, tremor, and poor response to intravenous immunoglobulin (IVIg). Although classically considered a peripheral disorder, central nervous system (CNS) involvement has been suggested, but functional neuroimaging correlates remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively analyzed seven male patients with NF155 antibody-positive nodopathy. Clinical and electrophysiological assessments were performed, and all patients underwent brain perfusion single-photon emission computed tomography (SPECT) using 123I-IMP iodoamphetamine. Imaging data were processed using three-dimensional stereotactic surface projection (3D-SSP) and compared to an age-matched database. Cerebellar hypoperfusion was defined as regional\n                      <jats:italic>z<\/jats:italic>\n                      -scores\u202f\u2264\u202f\u22122.0.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean patient age was 39.0\u202f\u00b1\u202f12.9\u202fyears, and mean disease duration was 5.0\u202f\u00b1\u202f3.9\u202fyears. Tremor was documented in all patients at some point during the disease course and was predominantly postural or kinetic. Cerebellar hypoperfusion was identified in six patients (86%), involving the cerebellum bilaterally in most cases, with variable degrees of asymmetry across individuals. No correlation was found between hypoperfusion and disease duration or age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cerebellar hypoperfusion was frequently observed in this single-center case series of anti-NF155 antibody-positive nodopathy. These findings are descriptive and hypothesis-generating, and compatible with a possible association between cerebellar perfusion abnormalities and tremor. Larger prospective studies are warranted to validate these observations and explore their clinical implications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1774074","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T05:51:33Z","timestamp":1774417893000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Cerebellar hypoperfusion in anti-NF155 antibody-positive nodopathy: a retrospective case series using brain perfusion SPECT"],"prefix":"10.3389","volume":"17","author":[{"given":"Hanna","family":"Okada","sequence":"first","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Juntendo University","place":["Tokyo, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Tomizawa","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Juntendo University","place":["Tokyo, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasunobu","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Juntendo University","place":["Tokyo, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Cossu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Juntendo University","place":["Tokyo, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidenori","family":"Ogata","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medical Sciences, Kyushu University","place":["Kyushu, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Isobe","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medical Sciences, Kyushu University","place":["Kyushu, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akifumi","family":"Hagiwara","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine, Juntendo University","place":["Tokyo, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumasa","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Juntendo University","place":["Tokyo, Japan"]},{"name":"Tohsei Center for Neurological Diseases","place":["Shizuoka, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taku","family":"Hatano","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Juntendo University","place":["Tokyo, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobutaka","family":"Hattori","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Juntendo University","place":["Tokyo, Japan"]},{"name":"Neuron-Glia Crosstalk Center, Faculty of Medicine, Juntendo University","place":["Tokyo, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"3556","DOI":"10.1111\/ene.14959","article-title":"European academy of neurology\/peripheral nerve society guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy","volume":"28","author":"den Van Bergh","year":"2021","journal-title":"Eur J Neurol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1212\/WNL.0000000000000205","article-title":"Neurofascin IgG4 antibodies in CIDP associate with disabling tremor and poor response to 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Neuroinflamm"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1111\/ene.15693","article-title":"Imbalance and lower limb tremor in chronic inflammatory demyelinating polyradiculoneuropathy","volume":"30","author":"Silsby","year":"2023","journal-title":"Eur J Neurol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1083\/jcb.150.3.657","article-title":"An oligodendrocyte cell adhesion molecule at the site of assembly of the paranodal axo-glial junction","volume":"150","author":"Tait","year":"2000","journal-title":"J Cell Biol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"665136","DOI":"10.3389\/fneur.2021.665136","article-title":"Anti-neurofascin 155 antibody-positive chronic inflammatory demyelinating polyneuropathy\/combined central and peripheral demyelination: strategies for diagnosis and treatment based on the disease mechanism","volume":"12","author":"Kira","year":"2021","journal-title":"Front Neurol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1002\/acn3.248","article-title":"Characterization of IgG4 anti-neurofascin 155 antibody-positive polyneuropathy","volume":"2","author":"Ogata","year":"2015","journal-title":"Ann Clin Transl Neurol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1212\/wnl.54.3.615","article-title":"Distal acquired demyelinating symmetric neuropathy","volume":"54","author":"Katz","year":"2000","journal-title":"Neurology"},{"key":"ref11","first-page":"1238","article-title":"A diagnostic approach in Alzheimer's disease using three-dimensional stereotactic surface projections of fluorine-18-FDG PET","volume":"36","author":"Minoshima","year":"1995","journal-title":"J Nucl Med"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"2222","DOI":"10.1172\/JCI124694","article-title":"Anti\u2013neurofascin-155 IgG4 antibodies prevent paranodal complex formation in vivo","volume":"129","author":"Manso","year":"2019","journal-title":"J Clin Invest"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2026.1774074\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T05:51:35Z","timestamp":1774417895000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2026.1774074\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,25]]},"references-count":12,"alternative-id":["10.3389\/fneur.2026.1774074"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2026.1774074","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,25]]},"article-number":"1774074"}}