{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T02:11:38Z","timestamp":1773195098477,"version":"3.50.1"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Obstructive sleep apnea syndrome (OSAS) is a common sleep-related breathing disorder associated with significant cardiovascular, metabolic, and neuropsychological consequences. Increasing evidence suggests that OSAS may also adversely affect male sexual function; however, sexual health remains underrecognized in routine clinical practice. This study aimed to evaluate the prevalence of sexual dysfunction in men with OSAS and to identify its clinical, psychological, and polysomnographic predictors using a multidimensional approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional study included 52 men diagnosed with OSAS and 40 age-matched healthy controls. All participants underwent overnight type 1 polysomnography. Daytime sleepiness, anxiety, depression, sexual function, and quality of life were assessed using the Epworth Sleepiness Scale (ESS), Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), Arizona Sexual Experience Scale (ASEX), and SF-36 questionnaire, respectively. Associations between sexual dysfunction and demographic, psychological, and sleep-related parameters were analyzed. Receiver operating characteristic (ROC) curve analysis was performed to evaluate predictive factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sexual dysfunction was significantly more prevalent in men with OSAS compared to controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.04) and was strongly associated with increasing OSAS severity. Men with sexual dysfunction exhibited significantly higher apnea\u2013hypopnea index (AHI), ESS, anxiety, and depression scores, along with lower physical functioning, vitality, and mental health scores (all\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). ROC analysis demonstrated that AHI was a significant associated factor of sexual dysfunction (AUC\u202f=\u202f0.709), with a sensitivity of 91% and specificity of 81% at a cutoff value of 59.75.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Sexual dysfunction in men is closely related to the severity of OSAS rather than its mere presence. AHI emerges as a key associated factor, highlighting the importance of comprehensive sexual and psychological assessment in the clinical management of men with OSAS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1778854","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T05:31:01Z","timestamp":1773120661000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of sexual dysfunction and its predictors in men with obstructive sleep apnea syndrome: a multidimensional clinical and psychological approach"],"prefix":"10.3389","volume":"17","author":[{"given":"Mehmet","family":"Kabak","sequence":"first","affiliation":[{"name":"Department of Chest Diseases, Mardin Artuklu University","place":["Mardin, T\u00fcrkiye"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bar\u0131\u015f","family":"\u00c7il","sequence":"additional","affiliation":[{"name":"Department of Chest Diseases, Mardin Training and Research Hospital","place":["Mardin, T\u00fcrkiye"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/S2213-2600(19)30198-5","article-title":"Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis","volume":"7","author":"Benjafield","year":"2019","journal-title":"Lancet Respir Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/S2213-2600(15)00043-0","article-title":"Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study","volume":"3","author":"Heinzer","year":"2015","journal-title":"Lancet Respir Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"52","DOI":"10.18773\/austprescr.2024.010","article-title":"Diagnosis and management of obstructive sleep apnoea in adults","volume":"47","author":"Hynes","year":"2024","journal-title":"Aust Prescr"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/j.jacc.2013.04.080","article-title":"Obstructive sleep apnea and the risk of sudden cardiac death: a longitudinal study of 10,701 adults","volume":"62","author":"Gami","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"766639","DOI":"10.3389\/fpsyt.2022.766639","article-title":"Erectile dysfunction and obstructive sleep apnea: a review","volume":"13","author":"Gu","year":"2022","journal-title":"Front Psych"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1038\/s41443-018-0017-7","article-title":"Association between obstructive sleep apnea and erectile dysfunction: a systematic review and meta-analysis","volume":"30","author":"Kellesarian","year":"2018","journal-title":"Int J Impot Res"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1530\/JOE-21-0155","article-title":"The links between sleep duration, obesity and type 2 diabetes mellitus","volume":"252","author":"Antza","year":"2021","journal-title":"J Endocrinol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1992","DOI":"10.1111\/jsm.12983","article-title":"Sexual dysfunction in patients with obstructive sleep apnea: a systematic review and meta-analysis","volume":"12","author":"Liu","year":"2015","journal-title":"J Sex Med"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"221","DOI":"10.5664\/jcsm.27817","article-title":"Outcome of CPAP treatment on intimate and sexual relationships in men with obstructive sleep apnea","volume":"6","author":"Reishtein","year":"2010","journal-title":"J Clin Sleep 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Med"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1097\/NMD.0b013e31816ff3bf","article-title":"The Epworth sleepiness scale in the identification of obstructive sleep apnea","volume":"196","author":"Rosenthal","year":"2008","journal-title":"J Nerv Ment Dis"},{"key":"ref14","first-page":"136","article-title":"Psychometric properties of the Persian version of Beck anxiety inventory (BAI)","volume":"2","author":"Kaviani","year":"2008","journal-title":"Tehran Univ Med J"},{"key":"ref15","first-page":"28","article-title":"Turkish version of the Beck anxiety inventory: psychometric properties","volume":"12","author":"Ulusoy","year":"1998","journal-title":"J Cognit Psychother"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1002\/da.20070","article-title":"Psychometric properties of a Persian-language version of the Beck depression inventory-second edition: 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thalassemia major: reliability and validity of the Persian version of the SF-36 questionnaire","volume":"54","author":"Jafari","year":"2008","journal-title":"J Postgrad Med"},{"key":"ref21","first-page":"102","article-title":"Reliability and validity of SF-36 for Turkish","volume":"12","author":"Ko\u00e7yi\u011fit","year":"1999","journal-title":"Journal of Drugs and Treatment"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/sj.ijir.3901225","article-title":"Aging and pathogenesis of erectile dysfunction","volume":"16","author":"Corona","year":"2004","journal-title":"Int J Impot Res"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"CD013169","DOI":"10.1002\/14651858.CD013169.pub2","article-title":"Non-invasive positive airway pressure therapy for improving erectile dysfunction in men with obstructive sleep apnoea","volume":"9","author":"Barbosa","year":"2021","journal-title":"Cochrane Database Syst 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An exploratory post hoc analysis","volume":"12","author":"Di Bello","year":"2023","journal-title":"J Clin Med"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1056\/NEJM200005113421901","article-title":"Prospective study of the association between sleep-disordered breathing and hypertension","volume":"342","author":"Peppard","year":"2000","journal-title":"N Engl J Med"},{"key":"ref27","first-page":"18","article-title":"Distribution of psychiatric disorders in patients with obstructive sleep apnea syndrome","volume":"15","author":"H\u0131d\u0131ro\u011flu","year":"2012","journal-title":"Turkish J Clin Psy"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1378\/chest.115.1.123","article-title":"Quality of life in patients with obstructive sleep apnea: effect of nasal continuous positive airway pressure--a prospective study","volume":"115","author":"D'Ambrosio","year":"1999","journal-title":"Chest"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1111\/j.1743-6109.2012.02968.x","article-title":"Long-term changes of sexual function in men with obstructive sleep apnea after initiation of continuous positive airway pressure","volume":"10","author":"Budweiser","year":"2013","journal-title":"J Sex Med"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"2317165","DOI":"10.1080\/13685538.2024.2317165","article-title":"Erectile dysfunction in patient with obstructive sleep apnea: effects of continuous positive airway pressure","volume":"27","author":"Kim","year":"2024","journal-title":"Aging Male"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"74","DOI":"10.4274\/jtsm.galenos.2021.04695","article-title":"Psychobiological personality traits related to sleep disorders and sexual dysfunction: a systematic review and meta-analysis","volume":"8","author":"Rezaei","year":"2021","journal-title":"J Turk Sleep Med"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"101787","DOI":"10.1016\/j.smrv.2023.101787","article-title":"Nocturia and obstructive sleep apnea syndrome: a systematic review","volume":"69","author":"Di Bello","year":"2023","journal-title":"Sleep Med Rev"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1002\/nau.25338","article-title":"Lower urinary tract symptoms in young-middle aged males with a diagnosis of obstructive sleep apnea syndrome","volume":"43","author":"Di Bello","year":"2024","journal-title":"Neurourol Urodyn"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"11236","DOI":"10.4081\/aiua.2023.11236","article-title":"Sexual dysfunction: time for a multidisciplinary approach?","volume":"95","author":"Cirillo","year":"2023","journal-title":"Arch Ital Urol Androl"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.3390\/medicina59071318","article-title":"Is continuous positive airway pressure a valid alternative to sildenafil in treating sexual dysfunction among OSA patients? 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