{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:11:20Z","timestamp":1778821880442,"version":"3.51.4"},"reference-count":87,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>\n                    The comorbidity between endometriosis and migraine has long been recognized clinically, yet a unifying pathophysiological explanation has remained elusive. Traditional models, centered on hormonal fluctuations or secondary inflammation are lacking to explain the fundamental predisposition underlying their co-occurrence. This review synthesizes the evidence from genetic epidemiology that is reshaping this narrative, positing that shared molecular genetic mechanisms provide the missing link. This review paper aims to present a review of the current literature surrounding genetic overlap between EM and migraine. Critically, Mendelian Randomization analyses refute a causal relationship, instead pointing to pleiotropy as the core principle. We delve into the specific shared risk loci, such as\n                    <jats:italic>TRIM32<\/jats:italic>\n                    and\n                    <jats:italic>SLC44A4<\/jats:italic>\n                    , and demonstrate how they converge on dysregulated biological pathways, notably IL-1, TNF-\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , and MAPK\/ERK signaling that drive both peripheral inflammation in endometriosis and neuroinflammation in migraine. Central sensitization emerges as a critical amplifier, functionally coupling the two conditions and exacerbating chronic pain. By integrating these findings, we propose a novel model where endometriosis and migraine are parallel manifestations of a shared genetic architecture. Finally, we discuss the translational implications of this paradigm, including the potential for genetic stratification of high-risk patients and the repurposing of therapeutics targeting these shared inflammatory pathways. This genetic reframing may move the field beyond symptomatic management toward a future of mechanism-based, personalized medicine for this underserved patient population.\n                  <\/jats:p>","DOI":"10.3389\/fneur.2026.1781023","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:28:17Z","timestamp":1778819297000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A review on shared genetic architecture of endometriosis and migraine: from pleiotropy to convergent inflammatory pathways"],"prefix":"10.3389","volume":"17","author":[{"given":"Qian","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Neurology, Tianjin Huanhu Hospital","place":["Tianjin, China"]},{"name":"Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases","place":["Tianjin, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengyuan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Chinese PLA General Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"03331024241235210","DOI":"10.1177\/03331024241235210","article-title":"Correlation between endometriosis and migraine features: results from a prospective case-control study","volume":"44","author":"Selntigia","year":"2024","journal-title":"Cephalalgia"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/s10194-025-02020-4","article-title":"The association between endometriosis and migraine: a systematic review and meta-analysis of observational studies","volume":"26","author":"Colombo","year":"2025","journal-title":"J Headache 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