{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T16:31:47Z","timestamp":1792254707495,"version":"4.4.0"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The role of flow diverters (FDs) in middle cerebral artery (MCA) M1 aneurysms is not well established. We assessed their safety, efficacy, and predictors of incomplete occlusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive MCA M1 aneurysms treated with FDs (January 2022\u2013May 2024) were retrospectively reviewed. Clinical, imaging, and procedural variables were analyzed for associations with ischemic complications and angiographic outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty-eight patients (mean age 57.5\u202fyears; 46.6% female) underwent treatment with Pipeline (56.9%), Tubridge (20.7%), Surpass Evolve (12.1%), or Lattice (10.3%) devices. Postprocedural cerebral ischemia occurred in 25.9% (15\/58), significantly more often in ruptured versus unruptured aneurysms (26.7% vs. 2.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.013). Rupture independently predicted ischemia (OR 15.273, 95% CI 1.547\u2013150.765;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.020). At a median follow-up of 13\u202fmonths, complete occlusion was achieved in 77.4% (41\/53). Aneurysm wall enhancement on MRI independently predicted incomplete occlusion (OR 6.566, 95% CI 1.395\u201330.903;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.017).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>FDs may be an option for carefully selected MCA M1 aneurysms. Ruptured aneurysms are associated with a markedly higher risk of postoperative ischemic complications, and aneurysm wall enhancement on preoperative MRI independently predicts incomplete aneurysm occlusion after FDs treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1782648","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T13:01:22Z","timestamp":1775134882000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Flow diverter treatment for MCA M1 aneurysms: clinical outcomes and predictors of occlusion"],"prefix":"10.3389","volume":"17","author":[{"given":"Zeran","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital of Fudan University","place":["Shanghai, China"]},{"name":"National Center for Neurological Disorders, Huashan Hospital, Shanghai Medical College, Fudan University","place":["Shanghai, China"]},{"name":"Department of Neurosurgery, The Affiliated Hospital of Yunnan University, The Second People\u2019s Hospital of Yunnan, Yunnan University","place":["Kunming, China"]},{"name":"The Stroke Center, The Affiliated Hospital of Yunnan University, The Second People\u2019s Hospital of Yunnan, Yunnan University","place":["Kunming, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiabin","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital of Fudan University","place":["Shanghai, China"]},{"name":"National Center for Neurological Disorders, Huashan Hospital, Shanghai Medical College, Fudan University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjie","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital of Fudan University","place":["Shanghai, China"]},{"name":"National Center for Neurological Disorders, Huashan Hospital, Shanghai Medical College, Fudan University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiyuan","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital of Fudan University","place":["Shanghai, China"]},{"name":"National Center for Neurological Disorders, Huashan Hospital, Shanghai Medical College, Fudan University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchao","family":"Fei","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital of Fudan University","place":["Shanghai, China"]},{"name":"National Center for Neurological Disorders, Huashan Hospital, Shanghai Medical College, Fudan University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital of Fudan University","place":["Shanghai, China"]},{"name":"National Center for Neurological Disorders, Huashan Hospital, Shanghai Medical College, Fudan University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiang","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital of Fudan University","place":["Shanghai, China"]},{"name":"National Center for Neurological Disorders, Huashan Hospital, Shanghai Medical College, Fudan University","place":["Shanghai, China"]},{"name":"Department of Neurosurgery, The First Affiliated Hospital of Fujian Medical University","place":["Fuzhou, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital of Fudan University","place":["Shanghai, China"]},{"name":"National Center for Neurological Disorders, Huashan Hospital, Shanghai Medical College, Fudan University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.3171\/2018.7.JNS18654","article-title":"Flow diversion treatment of complex bifurcation aneurysms beyond the circle of Willis: complications, aneurysm sac occlusion, reabsorption, recurrence, and jailed branch modification at follow-up","volume":"131","author":"Michelozzi","year":"2018","journal-title":"J Neurosurg"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1136\/neurintsurg-2015-011682","article-title":"Flow diversion treatment of complex bifurcation aneurysms beyond the circle of Willis: a single-center series with special emphasis on covered cortical branches and perforating arteries","volume":"8","author":"Gawlitza","year":"2016","journal-title":"J 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A surpass evolve single-center study","volume":"32","author":"Gupta","year":"2024","journal-title":"J Endovasc Ther"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.3390\/jcm8101649","article-title":"Delayed stroke after aneurysm treatment with flow diverters in small cerebral vessels: a potentially critical complication caused by subacute vasospasm","volume":"8","author":"Schob","year":"2019","journal-title":"J Clin Med"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1227\/NEU.0000000000000579","article-title":"Use of coils in conjunction with the pipeline embolization device for treatment of intracranial aneurysms","volume":"76","author":"Lin","year":"2015","journal-title":"Neurosurgery"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2026.1782648\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T13:01:23Z","timestamp":1775134883000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2026.1782648\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,2]]},"references-count":30,"alternative-id":["10.3389\/fneur.2026.1782648"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2026.1782648","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,2]]},"article-number":"1782648"}}