{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:15:24Z","timestamp":1790126124815,"version":"4.0.1"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hepatic encephalopathy (HE) involves complex neurobiological changes that are often difficult to quantify using conventional MRI. This study aims to utilize Neurite Orientation Dispersion and Density Imaging (NODDI) combined with Gray-matter Based Spatial Statistics (GBSS) to characterize microstructural alterations in patients with HE and explore their relationship with clinical biochemical markers, specifically within the globus pallidus (GP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty-three patients with HE and 31 healthy controls underwent 3\u202fT MRI including a multi-shell diffusion protocol for NODDI. GBSS was performed to assess differences in the Neurite Density Index (NDI) and Orientation Dispersion Index (ODI). Pearson correlation analyzed relationships between GP NODDI parameters and blood biochemical indices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      HE patients exhibited significantly decreased NDI across widespread cortical and sub-cortical regions (frontal, parietal, temporal, cingulate, insula, thalamus) and increased ODI in the posterior cerebellum\/vermis. Exploratory ROI analysis of the globus pallidus (GP)\u2014a region known for manganese deposition but showing no significant group-level differences in this study- revealed that, the NDI of the right GP showed positive correlations with indirect bilirubin and prothrombin international normalized ratio (all uncorrected\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05), while the ODI of the left GP positively correlated with hemoglobin concentration (uncorrected\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.046).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>NODDI reveals extensive microstructural alterations consistent with reduced neurite density index and cerebellar disorganization in HE. The dissociated correlation patterns of GP NDI and ODI with distinct blood markers may be compatible with a hypothetical \u201cdouble-hit\u201d pathophysiological model: toxic metabolite accumulation may drive cellular swelling (increased NDI), while systemic factors like anemia may reduce structural complexity (decreased ODI). However, these exploratory associations do not allow causal inference. These findings highlight NODDI could be a useful tool for monitoring the progression and metabolic impact of HE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1783288","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T05:21:00Z","timestamp":1772428860000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Gray matter microstructural alterations and their correlation with systemic biomarkers in hepatic encephalopathy: a NODDI study using gray-matter based spatial statistics"],"prefix":"10.3389","volume":"17","author":[{"given":"Fengli","family":"Xie","sequence":"first","affiliation":[{"name":"Medical Imaging Center, The Second Affiliated Hospital of Henan University of Science and Technology","place":["Luoyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical Imaging Center, The Second Affiliated Hospital of Henan University of Science and Technology","place":["Luoyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huina","family":"Zhang","sequence":"additional","affiliation":[{"name":"Medical Imaging Center, The Second Affiliated Hospital of Henan University of Science and Technology","place":["Luoyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical Imaging Center, The Second Affiliated Hospital of Henan University of Science and Technology","place":["Luoyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaofeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical Imaging Center, The Second Affiliated Hospital of Henan University of Science and Technology","place":["Luoyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Cheng","sequence":"additional","affiliation":[{"name":"Medical Imaging Center, The Second Affiliated Hospital of Henan University of Science and Technology","place":["Luoyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Medical Imaging Center, The Second Affiliated Hospital of Henan University of Science and Technology","place":["Luoyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haohui","family":"Zhan","sequence":"additional","affiliation":[{"name":"Medical Imaging Center, The Second Affiliated Hospital of Henan University of Science and Technology","place":["Luoyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1002\/hep.27210","article-title":"Hepatic encephalopathy in chronic liver disease: 2014 practice guideline by the American Association for the Study of Liver Diseases and the European Association for the Study of the liver","volume":"60","author":"Vilstrup","year":"2014","journal-title":"Hepatology"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/hepr.70091","article-title":"Efficacy of MR imaging findings in clinical management of hepatic encephalopathy and Alzheimer's disease","volume":"56","author":"Kim","year":"2025","journal-title":"Hepatol Res"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1007\/s11011-024-01512-7","article-title":"Ammonia and beyond - biomarkers of hepatic 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