{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T17:05:42Z","timestamp":1773335142764,"version":"3.50.1"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Osteoporosis may increase the risk of benign paroxysmal positional vertigo (BPPV). However, direct evidence remains elusive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To analyze the correlation between bone mineral density (BMD) and vestibular function in elderly patients with BPPV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two hundred ninety-one idiopathic, unilateral BPPV patients aged 50\u201380 years were consecutively enrolled in our vertigo outpatient clinic. All the participants underwent BMD, cervical, and ocular vestibular evoked myogenic potential (c\/oVEMP) evaluations. The associations between BMD and VEMP results were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty-one patients (27.8%) were diagnosed with osteoporosis, 120 patients (41.2%) had osteopenia, and 90 (30.9%) exhibited normal BMD. Among BPPV patients, abnormal BMD demonstrated a marginal correlation with oVEMP response (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.098), but not with cVEMP response (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.405). Compared to those without osteoporosis, patients with osteoporosis were older (65.9 vs. 62.7 years,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001), had lower BMI (22.6 vs. 24.3,\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.001), showed a higher proportion of females (84.0 vs. 72.4%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.039), and were more likely to present with at least unilateral oVEMP absence (74.1 vs. 57.1%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.008). Patients exhibiting at least unilateral oVEMP absence also had reduced T-scores and BMD in the lumbar spine. After adjusting for confounding variables, osteoporosis remained independently associated with at least unilateral oVEMP absence in BPPV patients (OR = 2.038,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.019).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study provides further evidence that osteoporosis may contribute to utricular dysfunction associated with the occurrence of BPPV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1785323","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:27:43Z","timestamp":1773293263000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Osteoporosis correlates with abnormal ocular vestibular evoked myogenic potential in patients with benign paroxysmal positional vertigo"],"prefix":"10.3389","volume":"17","author":[{"given":"Chen-Yan","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Neurology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shanghai Second 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China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]},{"name":"Ear Institute, Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]},{"name":"Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Ren","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-Bin","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth 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