{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T14:13:03Z","timestamp":1779372783792,"version":"3.53.1"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The population of patients with first-onset ischemic stroke at or above the age of 80 is steadily growing. However, the distinct lipid profile characteristics of this oldest-old cohort remain systematically undefined. This study aimed to delineate these lipid patterns and elucidate their association with the late onset of acute ischemic stroke in advanced age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort analysis of patients with first-ever acute ischemic stroke consecutively enrolled between March 2022 and June 2025. To mitigate confounding by lipid-lowering therapies, a critical modifier of both lipid metabolism and cerebrovascular risk, we implemented strict exclusion criteria for any prior exposure to cholesterol-modulating agents. Participants were stratified into three age groups: youngest-old (60\u201369\u202fyears), middle-old (70\u201379\u202fyears), and oldest-old (\u226580\u202fyears). Demographic characteristics and lipid parameters were systematically analyzed across groups, with correlation and multivariate regression analyses performed to identify lipid-related predictors of late-onset ischemic stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 565 patients were included in the final analysis based on our inclusion and exclusion criteria (239 youngest-old; 200 middle-old; 126 oldest-old). The oldest-old group exhibited significantly lower levels of total cholesterol, triglycerides, apolipoprotein B, low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), and reduced LDL-C\/HDL-C and VLDL-C\/HDL-C ratios compared to younger cohorts (all\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u202f0.05). Additionally, this group demonstrated decreased prevalence rates of dyslipidemia subtypes, particularly for total cholesterol, triglycerides, LDL-C, and VLDL-C abnormalities. Notably, 11 distinct patterns of combined dyslipidemia showed diminished frequency in the oldest-old. Multivariate analysis identified non-HDL-C as the strongest lipid predictor of late-onset ischemic stroke in the overall population, with gender-specific variations: LDL-C emerged as the primary contributor in females, whereas triglycerides showed predominant association in males.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings suggest a distinct lipid profile in older adults with late-onset ischemic stroke. A key implication for management is that non-HDL-C should be elevated to a co-primary target alongside LDL-C in public health strategies for lipid control.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1786974","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:27:42Z","timestamp":1778819262000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Lipid feature and late onset \u226580\u202fyears of ischemic stroke: a retrospective study in lipid-lowering therapy-naive adults"],"prefix":"10.3389","volume":"17","author":[{"given":"Shusheng","family":"Jiao","sequence":"first","affiliation":[{"name":"Department of Neurology, Bethune International Peace Hospital","place":["Shijiazhuang, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Jiangbin Hospital of Guangxi Zhuang Autonomous Region","place":["Nanning, Guangxi Zhuang Autonomous Region, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Dazu District Hospital of Traditional Chinese Medicine","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Bethune International Peace Hospital","place":["Shijiazhuang, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1080\/00224545.2022.2068994","article-title":"Gender ideology and fertility: evidence for a curvilinear hypothesis","volume":"164","author":"Stefani","year":"2024","journal-title":"J Soc 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