{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T06:15:14Z","timestamp":1783318514575,"version":"3.54.6"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"\n Background<\/jats:title>\n This study evaluates the efficacy of ultrasound-guided platelet-rich plasma (PRP) treatment in promoting nerve regeneration and improving functional outcomes in patients with peripheral nerve injuries (PNI) of the forearm.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A retrospective analysis was conducted on 183 patients diagnosed with unilateral forearm median or ulnar nerve injuries, classified as grade II or III according to the Sunderland system. Patients were divided into a conventional rehabilitation group (\n n<\/jats:italic>\n \u202f=\u202f105) and a PRP group (\n n<\/jats:italic>\n \u202f=\u202f78), which received additional ultrasound-guided PRP injections. Primary outcomes included nerve cross-sectional diameter, cross-sectional area, and Disabilities of the Arm, Shoulder, and Hand (DASH) scores. Secondary outcomes encompassed neurophysiological activity, motor and sensory function, and serum indicators of nerve function.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Post-treatment, the PRP group demonstrated a significantly larger nerve cross-sectional diameter (\n p<\/jats:italic>\n \u202f=\u202f0.021) and a significantly larger cross-sectional area (\n p<\/jats:italic>\n \u202f=\u202f0.004) compared to the conventional group. DASH scores were significantly lower in the PRP group at 2 months post-treatment (\n p<\/jats:italic>\n \u202f=\u202f0.008), indicating improved functional outcomes. Additionally, the PRP group exhibited higher sensory conduction velocity (\n p<\/jats:italic>\n \u202f=\u202f0.042) and motor conduction velocity (\n p<\/jats:italic>\n \u202f=\u202f0.044), along with improved Medical Research Council (MRC) muscle strength and British Medical Research Council (BMRC) sensory function scores at multiple follow-up points (all\n p<\/jats:italic>\n \u202f&lt;\u202f0.05). Serum levels of brain-derived neurotrophic factor (BDNF) (\n p<\/jats:italic>\n \u202f=\u202f0.006), nerve growth factor (NGF) (\n p<\/jats:italic>\n \u202f=\u202f0.002), and neurotrophin-3 (NT-3) (\n p<\/jats:italic>\n \u202f=\u202f0.007) were also significantly elevated in the PRP group.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Ultrasound-guided PRP treatment significantly enhances nerve regeneration and functional recovery in patients with forearm PNI compared to conventional rehabilitation alone, suggesting its potential as an effective adjunctive therapy.<\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fneur.2026.1787289","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T05:37:34Z","timestamp":1783316254000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessing the efficacy of ultrasound-guided platelet-rich plasma on nerve regeneration and functional outcomes in forearm peripheral nerve injuries: a retrospective observational study"],"prefix":"10.3389","volume":"17","author":[{"given":"Qing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pain Treatment, The Second Affiliated Hospital of University of South China","place":["Hengyang, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Pain Treatment, The Second Affiliated Hospital of University of South China","place":["Hengyang, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Second Affiliated Hospital of University of South China","place":["Hengyang, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion, The Second Affiliated Hospital of University of South China","place":["Hengyang, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, The Second Affiliated Hospital of University of South China","place":["Hengyang, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, The Second Affiliated Hospital of University of South China","place":["Hengyang, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, The Second Affiliated Hospital of University of South China","place":["Hengyang, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"918","DOI":"10.3390\/ijms23020918","article-title":"Peripheral nerve injury treatments and advances: one health perspective","volume":"23","author":"Lopes","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1097\/WCO.0000000000001116","article-title":"Traumatic peripheral nerve injuries: diagnosis and management","volume":"35","author":"Barnes","year":"2022","journal-title":"Curr Opin Neurol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1016\/j.injury.2022.01.031","article-title":"Approach to management of nerve gaps in peripheral nerve 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