{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T17:50:47Z","timestamp":1793469047282,"version":"4.5.0"},"reference-count":112,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Post-stroke depression (PSD) is a common neuropsychiatric complication affecting 30\u201350% of stroke survivors, impairing rehabilitation, quality of life, and prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main body<\/jats:title>\n                    <jats:p>This narrative review synthesizes recent evidence on PSD pathogenesis (neurotransmitter dysregulation, neuroinflammation, impaired neuroplasticity; psychosocial factors such as stress and social support deficits; gene\u2013environment interactions including 5-HTT and BDNF polymorphisms), clinical interventions (pharmacotherapy with SSRIs\/SNRIs, psychotherapy including CBT, neuromodulation via rTMS\/tDCS\/ECT, novel agents such as ketamine, and multidisciplinary models), and prevention (risk stratification, early screening with PHQ-9\/HAMD, personalized biological\/psychosocial strategies, and digital monitoring).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite gaps in long-term data and validated biomarkers, multidisciplinary integrated care and precision medicine approaches offer promising avenues to optimize screening, early intervention, prevention, and long-term outcomes for stroke survivors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1789695","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T05:38:34Z","timestamp":1773812314000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Research advances on the pathogenesis and clinical interventions of post-stroke depression"],"prefix":"10.3389","volume":"17","author":[{"given":"Leqi","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Neurology, Third Affiliated Hospital of Guangxi University of Chinese Medicine\/Liuzhou Hospital of Traditional Chinese Medicine","place":["Liuzhou, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiazhao","family":"Song","sequence":"additional","affiliation":[{"name":"Experimental Tumorpathology, University Hospital Erlangen, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","place":["Erlangen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moze","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Third Affiliated Hospital of Guangxi University of Chinese Medicine\/Liuzhou Hospital of Traditional Chinese Medicine","place":["Liuzhou, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Third Affiliated Hospital of Guangxi University of Chinese Medicine\/Liuzhou Hospital of Traditional Chinese Medicine","place":["Liuzhou, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Third Affiliated Hospital of Guangxi University of Chinese Medicine\/Liuzhou Hospital of Traditional Chinese Medicine","place":["Liuzhou, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minmin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Third Affiliated Hospital of Guangxi University of Chinese Medicine\/Liuzhou Hospital of Traditional Chinese Medicine","place":["Liuzhou, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"An","sequence":"additional","affiliation":[{"name":"Department of Neurology, Third Affiliated Hospital of Guangxi University of Chinese Medicine\/Liuzhou Hospital of Traditional Chinese Medicine","place":["Liuzhou, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheyi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurology, Third Affiliated Hospital of Guangxi University of Chinese Medicine\/Liuzhou Hospital of Traditional Chinese Medicine","place":["Liuzhou, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanyu","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital of Guangxi University of Chinese Medicine","place":["Nanning, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Affiliated Hospital of Traditional Chinese Medicine, Guangzhou Medical University","place":["Guangzhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1595160","DOI":"10.3389\/fphar.2025.1595160","article-title":"Post stroke depression: pathogenesis and molecular mechanisms of natural product-based interventions","volume":"16","author":"Gao","year":"2025","journal-title":"Front Pharmacol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1186\/s12883-024-03867-x","article-title":"Prevalence and associated factors of post-stroke depression in Africa: a systematic review and 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