{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:51:29Z","timestamp":1781880689983,"version":"3.54.5"},"reference-count":70,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Chronic insomnia frequently coexists with mild cognitive impairment (MCI) and may aggravate cognitive and daytime dysfunction. Pharmacological treatments can cause adverse effects, and cognitive behavioral therapy for insomnia (CBT-I) may be limited by resource and accessibility barriers. Acupuncture is a commonly used non-pharmacological intervention, but sham-controlled evidence in patients with chronic insomnia and comorbid MCI remains limited. This protocol describes, to our knowledge, one of the few sham-controlled randomized trials specifically targeting this comorbid population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>This is a single-center, participant- and assessor-blinded, sham-controlled, parallel-group randomized clinical trial. Eighty-two participants with chronic insomnia and MCI will be randomized in a 1:1 ratio to an acupuncture group or a sham-acupuncture group. Both groups will receive 10 sessions over approximately 4\u202fweeks, followed by 1-week and 1-month follow-up assessments; total participation will last approximately 8\u20139\u202fweeks. The single primary endpoint is the between-group difference in change in Pittsburgh Sleep Quality Index (PSQI) total score from baseline to post-treatment (week 4). Key secondary outcomes are the Insomnia Severity Index (ISI), Montreal Cognitive Assessment-Basic (MoCA-B), and Mini-Mental State Examination (MMSE). Other secondary outcomes include polysomnography (PSG), activities of daily living (ADL), executive-function tests (DST, SCWT, TMT), mood symptoms (BAI, BDI), daytime functioning (FSS, ESS), feasibility\/acceptability indices, and safety. Resting-state electroencephalography (EEG) outcomes are exploratory. The primary analysis will use the full analysis set and a repeated-measures linear mixed-effects model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>\n                      International Traditional Medicine Clinical Trial Registry (\n                      <jats:ext-link>http:\/\/itmctr.ccebtcm.org.cn\/<\/jats:ext-link>\n                      ), Identifier ITMCTR2025002221.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1790480","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T13:50:46Z","timestamp":1781877046000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Acupuncture for chronic insomnia with mild cognitive impairment: protocol for a randomized controlled trial"],"prefix":"10.3389","volume":"17","author":[{"given":"Xueqian","family":"Jia","sequence":"first","affiliation":[{"name":"The First School of Clinical Medicine, Zhejiang Chinese Medical University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gongyue","family":"Zhou","sequence":"additional","affiliation":[{"name":"The First School of Clinical Medicine, Zhejiang Chinese Medical University","place":["Hangzhou, China"]},{"name":"Department of Acupuncture and Moxibustion, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Shen","sequence":"additional","affiliation":[{"name":"The First School of Clinical Medicine, Zhejiang Chinese Medical University","place":["Hangzhou, China"]},{"name":"Department of Acupuncture and Moxibustion, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangyi","family":"Lin","sequence":"additional","affiliation":[{"name":"The First School of Clinical Medicine, Zhejiang Chinese Medical University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Moxibustion, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Moxibustion, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Preventive Treatment, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Moxibustion, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"102121","DOI":"10.1016\/j.smrv.2025.102121","article-title":"Estimation of the global prevalence and burden of insomnia: a systematic literature 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