{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T05:11:31Z","timestamp":1779253891641,"version":"3.51.4"},"reference-count":48,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sexsomnia is a NREM parasomnia involving involuntary sleep-related sexual behaviors that has attracted increasing clinical and forensic attention. However, the existing literature remains fragmented and largely dominated by case reports and small clinical series.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This umbrella review aims to synthesize review-level evidence by integrating clinical and neurophysiological insights while identifying critical gaps in diagnosis and management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Following PRISMA 2020 guidelines, major databases were systematically searched up to January 2025. Systematic, narrative, and scoping reviews were included and assessed using the AMSTAR 2 tool.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nine reviews were analyzed. Sexsomnia is consistently described as a disorder of arousal emerging from N2\/N3 sleep, characterized by sexual automatisms and subsequent amnesia. Neurophysiological findings support a model of state dissociation between motor activation and incomplete cortical awakening. Key triggers include sleep deprivation, alcohol consumption, and obstructive sleep apnea. Diagnostic challenges persist, particularly in differentiating involuntary behaviors from deliberate acts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite recognition as a clinical entity, sexsomnia lacks standardized diagnostic criteria and robust empirical evidence. Future research should focus on establishing consensus diagnostic frameworks and validating objective assessment tools.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1795824","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:48:08Z","timestamp":1779252488000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Sexsomnia: an umbrella review of clinical, neurophysiological and diagnostic evidence"],"prefix":"10.3389","volume":"17","author":[{"given":"Ioannis","family":"Mavroudis","sequence":"first","affiliation":[{"name":"Leeds Teaching Hospitals, NHS Trust","place":["Leeds, United Kingdom"]},{"name":"Romanian Academy of Scientists (Academia Oamenilor de \u0218tiin\u021b\u0103 din Rom\u00e2nia)","place":["Bucharest, Romania"]},{"name":"Third Department of Neurology, Aristotle University of Thessaloniki","place":["Thessaloniki, Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Foivos","family":"Petridis","sequence":"additional","affiliation":[{"name":"Third Department of Neurology, Aristotle University of Thessaloniki","place":["Thessaloniki, Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alin","family":"Ciobica","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Biology, \u201cAlexandru Ioan Cuza\u201d University of Iasi","place":["Iasi, Romania"]},{"name":"\u201cIoan H\u0103ulic\u0103\u201d Institute, \u201cApollonia\u201d University of Ia\u0219i","place":["Iasi, Romania"]},{"name":"\"Olga Necrasov\" Center, Biomedical Research Group, Romanian Academy, Iasi","place":["Iasi, Romania"]},{"name":"CENEMED Platform for Interdisciplinary Research, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d","place":["Ia\u0219i, Romania"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxana","family":"Cojocariu","sequence":"additional","affiliation":[{"name":"Department of Biological and Morphological Sciences, Faculty of Medicine and Biological Science, Stefan Cel Mare University of Suceava","place":["Suceava, Romania"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Kazis","sequence":"additional","affiliation":[{"name":"Third Department of Neurology, Aristotle University of Thessaloniki","place":["Thessaloniki, Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Adel Mansour","family":"Kamar","sequence":"additional","affiliation":[{"name":"GUPCO \u2013 Medical Department","place":["Cairo, Egypt"]},{"name":"Department of Orthopedics and Traumatology, Clinical Recovery Hospital (Recuperare)","place":["Iasi, Romania"]},{"name":"Doctoral School of Biology, Faculty of Biology, \u201cAlexandru Ioan Cuza\u201d University of Ia\u0219i","place":["Iasi, Romania"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u0103t\u0103lina","family":"Ionescu","sequence":"additional","affiliation":[{"name":"\u201cIoan H\u0103ulic\u0103\u201d Institute, \u201cApollonia\u201d University of Ia\u0219i","place":["Iasi, Romania"]},{"name":"Doctoral School of Biology, Faculty of Biology, \u201cAlexandru Ioan Cuza\u201d University of Ia\u0219i","place":["Iasi, Romania"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Gheban","sequence":"additional","affiliation":[{"name":"\u201cIoan H\u0103ulic\u0103\u201d Institute, \u201cApollonia\u201d University of Ia\u0219i","place":["Iasi, Romania"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catalin","family":"Morosan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Grigore T. 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