{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T06:13:15Z","timestamp":1788415995110,"version":"build-2803163510"},"reference-count":160,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Migraine is a prevalent and disabling neurological disorder. Resting-state functional magnetic resonance imaging (rs-fMRI) studies have investigated regional intrinsic neural activity alterations in migraine but have often yielded inconsistent findings. Emerging network perspectives suggest that brain disorders may be better understood through disruptions in large-scale networks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This systematic review included 31 rs-fMRI studies (1,238 migraine patients; 1,005 controls; 302 altered ALFF\/ReHo coordinates) to clarify these discrepancies. Using functional connectivity network mapping (FCNM) with Human Connectome Project data (n\u202f=\u202f1,093), we identified that heterogeneous regional intrinsic neural activity alterations in migraine converge onto common brain functional networks. Spatial relationships between the identified brain networks and the distribution of major neurotransmitter receptors\/transporters were subsequently characterized using the Juspace toolbox.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>FCNM analysis revealed that heterogeneous regional intrinsic neural activity alterations reported in migraine studies mapped to common brain functional networks, particularly within visual, somatomotor, and attention systems. The FCNM-identified migraine network exhibited significant spatial correlations with normative distributions of metabotropic glutamate receptor 5 (mGluR5), 5-hydroxytryptamine receptor 2A (5-HT2A), and noradrenaline transporter (NAT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that intrinsic neural dysfunctions in migraine map to large-scale networks with multi-neurochemical susceptibility. This framework suggests that heterogeneous regional intrinsic activity alterations in migraine are preferentially connected to visual, somatomotor, and attentional systems and are spatially aligned with normative neurochemical maps. These findings are hypothesis-generating and should not be interpreted as evidence of causality or patient-specific receptor alterations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1796739","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:21:22Z","timestamp":1788412882000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Network localization of regional intrinsic neural activity alterations in migraine and their neurochemical correlates"],"prefix":"10.3389","volume":"17","author":[{"given":"Hu-Cheng","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Radiology, The Yancheng School of Clinical Medicine of Nanjing Medical University, Yancheng Third People\u2019s Hospital","place":["Yancheng, China"]},{"name":"Binhai Maternal and Child Health Hospital","place":["Yancheng, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Jia","family":"Bian","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Yancheng School of Clinical Medicine of Nanjing Medical University, Yancheng Third People\u2019s Hospital","place":["Yancheng, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi-Lei","family":"Gao","sequence":"additional","affiliation":[{"name":"Binhai Maternal and Child Health Hospital","place":["Yancheng, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Mei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Binhai Maternal and Child Health Hospital","place":["Yancheng, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping-Lei","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Yancheng School of Clinical Medicine of Nanjing Medical University, Yancheng Third People\u2019s Hospital","place":["Yancheng, China"]},{"name":"Department of Central Laboratory, The Yancheng School of Clinical Medicine of Nanjing Medical University, Yancheng Third People\u2019s Hospital","place":["Yancheng, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Yancheng School of Clinical Medicine of Nanjing Medical University, Yancheng Third People\u2019s Hospital","place":["Yancheng, China"]},{"name":"Yancheng Maternal and Child Health Care Hospital Affiliated to Yangzhou University","place":["Yancheng, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Yu","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Yancheng School of Clinical Medicine of Nanjing Medical University, Yancheng Third People\u2019s Hospital","place":["Yancheng, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Yu","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Yancheng School of Clinical Medicine of Nanjing Medical University, Yancheng Third People\u2019s Hospital","place":["Yancheng, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"3331024241274343","DOI":"10.1177\/03331024241274343","article-title":"Disability in migraine: multicountry results from the chronic migraine epidemiology and outcomes - international (CaMEO-I) study","volume":"44","author":"Katsarava","year":"2024","journal-title":"Cephalalgia"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1111\/head.14099","article-title":"A link between gastrointestinal disorders and migraine: insights into the gut-brain connection","volume":"61","author":"Aurora","year":"2021","journal-title":"Headache"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/s10194-021-01294-8","article-title":"Investigating the relationships between the burden of multiple sensory hypersensitivity symptoms and headache-related disability in patents with migraine","volume":"22","author":"Suzuki","year":"2021","journal-title":"J Headache Pain"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/s41582-022-00763-1","article-title":"Global epidemiology of migraine and its implications for public health and health policy","volume":"19","author":"Steiner","year":"2023","journal-title":"Nat Rev Neurol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1080\/01616412.2024.2403860","article-title":"Use of ICHD-3rd diagnostic criteria in determining the prevalence of migraine in childhood; 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