{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T06:13:32Z","timestamp":1788416012926,"version":"build-2803163510"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The concurrence of anti-contactin-1 (CNTN1) antibody-associated autoimmune nodopathies (AN) and nephropathy has been sporadically reported, though the underlying relationship remains unclear. This case series study aimed to investigate the clinical characteristics and renal pathology of anti-CNTN1 antibody-associated AN with nephropathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective case series was conducted including 69 patients diagnosed with AN, among whom 11 patients tested positive for anti-CNTN1 antibodies. Clinical manifestations, electrophysiological data, laboratory results, and renal biopsy findings were collected and analyzed. The presence of nodal\/paranodal antibodies was confirmed using serum cell-based assays. Renal biopsies were performed in four patients, with immunohistochemical and immunofluorescence staining, including CNTN1 staining, to characterize renal pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to patients with non-anti-CNTN1 antibody-associated AN, the anti-CNTN1 antibody group had a significantly lower proportion of males (54.5% vs. 84.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.024) but showed higher rates of hypertension (36.4% vs. 8.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.021) and positive autoimmune antibodies (50% vs. 5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001). This group also exhibited a markedly higher prevalence of proteinuria (63.6% vs. 10.3%,\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u202f0.001) and nephropathy (63.6% vs. 3.4%,\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u202f0.001). Among anti-CNTN1 antibody-positive patients, females were more prone to concomitant nephropathy. Patients with both conditions exhibited onset ages ranging from 17 to 67\u202fyears, with a chronic course, frequent positive Romberg\u2019s sign, and prolonged distal motor and F-wave latencies. Renal biopsy in four patients revealed membranous nephropathy (MN) in three cases and lupus nephritis (LN) in one case. Notably, CNTN1 staining of kidney tissue was positive only in patients with anti-CNTN1 antibody-associated AN with MN.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Anti-CNTN1 antibody-associated AN patients have a higher prevalence of nephropathy compared to those AN without anti-CNTN1 antibodies. Females demonstrate a particularly higher risk of comorbid AN and nephropathy. Renal pathology in these patients is not limited to MN but can also include LN. These findings highlight a complex immunopathological relationship between anti-CNTN1 antibody-associated AN and nephropathy, warranting further studies to understand the underlying mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1801275","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:22:37Z","timestamp":1788412957000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The clinical features of anti-CNTN1 antibodies associated autoimmune nodopathies with nephropathy: a case series"],"prefix":"10.3389","volume":"17","author":[{"given":"Jinping","family":"Wan","sequence":"first","affiliation":[{"name":"Department of Neurology, Guigang City People\u2019s Hospital","place":["Guigang, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiegen","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Neurology, General Hospital of Southern Theater Command","place":["Guangzhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianian","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Huashan Hospital, Fudan University","place":["Shanghai, China"]},{"name":"Rare Disease Center, Huashan Hospital, Fudan University","place":["Shanghai, China"]},{"name":"National Center for Neurological Disorders (NCND)","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaojun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Huashan Hospital, Fudan University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Huashan Hospital, Fudan University","place":["Shanghai, China"]},{"name":"Rare Disease Center, Huashan Hospital, Fudan University","place":["Shanghai, China"]},{"name":"National Center for Neurological Disorders (NCND)","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongbo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Huashan Hospital, Fudan University","place":["Shanghai, China"]},{"name":"Rare Disease Center, Huashan Hospital, Fudan University","place":["Shanghai, China"]},{"name":"National Center for Neurological Disorders (NCND)","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurology, Huashan Hospital, Fudan University","place":["Shanghai, China"]},{"name":"Rare Disease Center, Huashan Hospital, Fudan University","place":["Shanghai, China"]},{"name":"National Center for Neurological Disorders (NCND)","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Guigang City People\u2019s Hospital","place":["Guigang, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e1098","DOI":"10.1212\/NXI.0000000000001098.","article-title":"Clinical and laboratory features in anti-NF155 autoimmune nodopathy","volume":"9","author":"Mart\u00edn-Aguilar","year":"2021","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"3556","DOI":"10.1111\/ene.14959","article-title":"European academy of neurology\/peripheral nerve society guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy: report of a joint task force-second 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