{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T05:09:36Z","timestamp":1779426576766,"version":"3.53.1"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Intracranial atherosclerosis-related large-vessel occlusion (ICAS-LVO) poses specific challenges during endovascular thrombectomy, and its early identification is clinically important for efficient recanalization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective, singlecenter study included consecutive patients who underwent magnetic resonance imaging (MRI) and endovascular thrombectomy for anterior circulation LVO. The candidate predictor set included predefined MRI markers and clinical variables, including atrial fibrillation, as documented in medical history or electrocardiogram. Variable importance was assessed using a random forest classifier, and the most informative MRI and clinical predictors were then entered into multivariable logistic regression to derive the point-based score. ICAS-LVO discrimination was quantified using the area under the receiver operating characteristic curve (AUC) and internally validated via bootstrap resampling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 335 eligible patients, 44 (13%) had ICAS-LVO. In the multivariable analysis, absence of atrial fibrillation (odds ratio [OR], 20.14; 95% confidence interval [CI], 6.02\u201389.89;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt; 0.001), multiple cortical\/border-zone infarcts (OR, 10.96; 95% CI, 3.65\u201334.90;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt; 0.001), mixed acute\u2013subacute lesions (OR, 5.10; 95% CI, 1.51\u201317.84;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f= 0.009), and absence of a susceptibility vessel sign (OR, 4.63; 95% CI, 1.81\u201312.51;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f= 0.002) were independently associated with ICAS\u2013LVO. The resulting ICAS-M score demonstrated high discrimination for ICAS-LVOs in this single-center cohort with 44 ICAS-LVO events (AUC 0.940), which was preserved during internal validation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In an MRI-capable thrombectomy center, the ICAS-M score demonstrated high, internally validated discrimination for ICAS-LVO and may support the rapid planning of ICAS-tailored endovascular strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1803264","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T04:51:28Z","timestamp":1779425488000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Magnetic resonance imaging and clinical prediction of intracranial atherosclerotic large vessel occlusion in acute ischemic stroke treated with endovascular thrombectomy"],"prefix":"10.3389","volume":"17","author":[{"given":"Yohei","family":"Tateishi","sequence":"first","affiliation":[{"name":"Department of Neurology and Strokology, Nagasaki University Hospital","place":["Nagasaki, Japan"]},{"name":"Unit of Clinical Medicine, Department of Clinical Neuroscience, Nagasaki University Graduate School of Biomedical Sciences","place":["Nagasaki, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Otsuka","sequence":"additional","affiliation":[{"name":"Department of Neurology and Strokology, Nagasaki University Hospital","place":["Nagasaki, Japan"]},{"name":"Unit of Clinical Medicine, Department of Clinical Neuroscience, Nagasaki University Graduate School of Biomedical Sciences","place":["Nagasaki, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Neurology and Strokology, Nagasaki University Hospital","place":["Nagasaki, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichiro","family":"Onizuka","sequence":"additional","affiliation":[{"name":"Department of Neurology and Strokology, Nagasaki University Hospital","place":["Nagasaki, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Amano","sequence":"additional","affiliation":[{"name":"Department of Neurology and Strokology, Nagasaki University Hospital","place":["Nagasaki, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiji","family":"Torimura","sequence":"additional","affiliation":[{"name":"Department of Neurology and Strokology, Nagasaki University Hospital","place":["Nagasaki, Japan"]},{"name":"Unit of Clinical Medicine, Department of Clinical Neuroscience, Nagasaki University Graduate School of Biomedical Sciences","place":["Nagasaki, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Tomita","sequence":"additional","affiliation":[{"name":"Department of Neurology and Strokology, Nagasaki University Hospital","place":["Nagasaki, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuro","family":"Hirayama","sequence":"additional","affiliation":[{"name":"Department of Neurology and Strokology, Nagasaki University Hospital","place":["Nagasaki, Japan"]},{"name":"Unit of Clinical Medicine, Department of Clinical Neuroscience, Nagasaki University Graduate School of Biomedical Sciences","place":["Nagasaki, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Shima","sequence":"additional","affiliation":[{"name":"Department of Neurology and Strokology, Nagasaki University Hospital","place":["Nagasaki, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Department of Neurology and Strokology, Nagasaki University Hospital","place":["Nagasaki, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teiichiro","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Neurology and Strokology, Nagasaki University Hospital","place":["Nagasaki, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Matsunaga","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nagasaki University Graduate School of Biomedical Sciences","place":["Nagasaki, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nagasaki University Graduate School of Biomedical Sciences","place":["Nagasaki, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Tsujino","sequence":"additional","affiliation":[{"name":"Department of Neurology and Strokology, Nagasaki University Hospital","place":["Nagasaki, Japan"]},{"name":"Unit of Clinical Medicine, Department of Clinical Neuroscience, Nagasaki University Graduate School of Biomedical Sciences","place":["Nagasaki, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2396","DOI":"10.1161\/STROKEAHA.107.505776","article-title":"Large artery intracranial occlusive disease: a large worldwide burden but a relatively neglected frontier","volume":"39","author":"Gorelick","year":"2008","journal-title":"Stroke"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2699","DOI":"10.1161\/STROKEAHA.118.022327","article-title":"Outcomes of endovascular treatment for acute intracranial atherosclerosis-related large vessel occlusion","volume":"49","author":"Baek","year":"2018","journal-title":"Stroke"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1161\/STROKEAHA.119.024889","article-title":"Thrombectomy outcomes of intracranial atherosclerosis-related occlusions","volume":"50","author":"Tsang","year":"2019","journal-title":"Stroke"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"E1996","DOI":"10.1212\/WNL.0000000000207194","article-title":"Association of Tirofiban with Functional Outcomes after Thrombectomy in acute ischemic stroke due to intracranial atherosclerotic disease","volume":"100","author":"Sang","year":"2023","journal-title":"Neurology"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.3171\/2022.1.JNS212924","article-title":"A simple score to predict atherosclerotic or embolic intracranial large-vessel occlusion stroke before endovascular 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stroke","volume":"46","author":"Mair","year":"2014","journal-title":"Stroke"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1212\/WNL.0000000000002236","article-title":"Effect of alteplase on the CT hyperdense artery sign and outcome after ischemic stroke","volume":"86","author":"Mair","year":"2016","journal-title":"Neurology"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"2206","DOI":"10.1161\/01.STR.0000026864.20339","article-title":"CT and diffusion-weighted MR imaging in randomized order: diffusion-weighted imaging results in higher accuracy and lower interrater variability in the diagnosis of hyperacute ischemic stroke","volume":"33","author":"Fiebach","year":"2002","journal-title":"Stroke"},{"key":"ref23","first-page":"878","article-title":"Sensitivity and interrater agreement of CT and diffusion-weighted MR imaging in Hyperacute stroke","volume":"24","author":"Saur","year":"2003","journal-title":"AJNR Am J 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