{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T13:50:23Z","timestamp":1793800223642,"version":"4.6.1"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Guided Project of Scientific and Technological Innovation in Changde City","award":["2024ZD236"],"award-info":[{"award-number":["2024ZD236"]}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore the role of dynamic monitoring of optic nerve sheath diameter (ONSD) in the assessment of intracranial pressure (ICP) in patients with traumatic brain injury (TBI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective study was conducted on patients with traumatic brain injury admitted to the Neurocritical Care Unit of the First People\u2019s Hospital of Changde between 01\/06\/2024 and 30\/09\/2025. All enrolled patients underwent invasive ICP monitoring. A 14\u20135\u202fMHz ultrasound probe was used to measure the ONSD in both eyes, with ICP values recorded simultaneously during ONSD measurements. Data were collected both before and 20\u202fmin after mannitol infusion administration. The Wilcoxon signed-rank test was used to compare ONSD and ICP before and after mannitol infusion, and Spearman correlation analysis was performed to assess their relationship.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 71 TBI patients were enrolled in this study, including 37 males and 34 females, with a mean age of 57.1\u202f\u00b1\u202f14.0\u202fyears. After mannitol infusion, ONSD significantly decreased from 6.39 (6.13, 6.73) mm to 4.94 (4.71, 5.61) mm (\n                      <jats:italic>p<\/jats:italic>\n                      =\u202f0.021). Concurrently, ICP decreased from 35 (32, 41) mmHg to 21 (17, 28) mmHg, with a statistically significant difference (\n                      <jats:italic>p<\/jats:italic>\n                      =\u202f0.010). Both ICP and ONSD were significantly lower after mannitol infusion compared to before infusion (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u202f0.05). Moreover, a significant correlation was observed between ICP and ONSD both before and after infusion (Spearman\u2019s\n                      <jats:italic>\u03c1<\/jats:italic>\n                      =\u202f0.860,\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u202f0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Dynamic monitoring of ONSD can reflect changes in intracranial pressure in patients with TBI, demonstrating potential utility in the assessment of intracranial hypertension.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1808654","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T05:36:23Z","timestamp":1776144983000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Dynamic optic nerve sheath diameter monitoring for intracranial pressure assessment in TBI patients"],"prefix":"10.3389","volume":"17","author":[{"given":"Liu","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Emergency Medical Service, The First People\u2019s Hospital of Changde City","place":["Changde, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Emergency Medical Service, The First People\u2019s Hospital of Changde City","place":["Changde, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medical Service, The First People\u2019s Hospital of Changde City","place":["Changde, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiting","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Emergency, The First People\u2019s Hospital of Changde City","place":["Changde, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medical Service, The First People\u2019s Hospital of Changde City","place":["Changde, Hunan, China"]},{"name":"Medical Education Center of Jinan University","place":["Guangzhou, Guangdong Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/S1474-4422(18)30469-1","article-title":"Traumatic brain injury in China","volume":"18","author":"Jiang","year":"2019","journal-title":"Lancet 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pressure monitoring in experimental traumatic brain injury: implications for clinical management","volume":"37","author":"Glushakova","year":"2020","journal-title":"J Neurotrauma"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1016\/S1474-4422(21)00138-1","article-title":"Intracranial pressure monitoring in patients with acute brain injury in the intensive care unit (SYNAPSE-ICU): an international, prospective observational cohort study","volume":"20","author":"Robba","year":"2021","journal-title":"Lancet Neurol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1111\/jon.12936","article-title":"Optic nerve sheath diameter measurement by ultrasound: evaluation of a standardized protocol","volume":"32","author":"Pansell","year":"2022","journal-title":"Neuroimaging"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.ajem.2016.09.044","article-title":"Optic nerve sheath diameter measurement: a means of 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consensus statement on optic nerve sheath diameter imaging and measurement","volume":"52","author":"Hirzallah","year":"2024","journal-title":"Crit Care Med"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"154464","DOI":"10.1016\/j.jcrc.2023.154464","article-title":"Optic nerve sheath diameter for assessing prognosis after out-of-hospital cardiac arrest","volume":"79","author":"Hohmann","year":"2024","journal-title":"J Crit Care"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.wneu.2024.06.087","article-title":"Advancements in ultrasound techniques for evaluating intracranial pressure through optic nerve sheath diameter measurement","volume":"189","author":"Fan","year":"2024","journal-title":"World Neurosurg"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"e42","DOI":"10.1016\/j.wneu.2024.08.111","article-title":"Ultrasonographic assessment of optic nerve sheath diameter as a screening tool for intracranial hypertension in traumatic brain iInjury","volume":"192","author":"Lioi","year":"2024","journal-title":"World Neurosurg"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"108310","DOI":"10.1016\/j.clineuro.2024.108310","article-title":"Optic nerve sheath diameter and eyeball transverse diameter in severe head injury and its correlation with intracranial pressure","volume":"242","author":"Breedt","year":"2024","journal-title":"Clin Neurol Neurosurg"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1111\/jon.12691","article-title":"Quantification of optic nerve and sheath diameter by transorbital sonography: a systematic review and metanalysis","volume":"30","author":"Schroeder","year":"2020","journal-title":"J Neuroimaging"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.pediatrneurol.2021.08.002","article-title":"Comparison of B-scan ultrasound and MRI-based optic nerve sheath diameter (ONSD) measurements in children","volume":"124","author":"Kerscher","year":"2021","journal-title":"Pediatr Neurol"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2026.1808654\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T05:36:25Z","timestamp":1776144985000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2026.1808654\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,14]]},"references-count":25,"alternative-id":["10.3389\/fneur.2026.1808654"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2026.1808654","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,14]]},"article-number":"1808654"}}