{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T09:31:22Z","timestamp":1793698282492,"version":"4.5.1"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Many patients still have poor functional outcomes after endovascular thrombectomy (EVT) for acute ischemic stroke. Systemic inflammatory indices from routine blood tests have been proposed as accessible prognostic biomarkers. We evaluated the association of admission neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI) with 6-month functional outcome after EVT, and tested whether they provide incremental prognostic value beyond the National Institutes of Health Stroke Scale (NIHSS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed consecutive patients undergoing EVT for anterior circulation acute ischemic stroke at one center. The primary outcome was poor functional outcome (modified Rankin Scale [mRS] 4\u20136) at 6\u202fmonths. Associations were assessed with logistic regression and ROC analysis. Incremental value over NIHSS was assessed with likelihood-ratio tests, AUC comparison (DeLong), reclassification metrics (NRI, IDI), and decision-curve analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 90 patients, 82 (91.1%) completed follow-up, of whom 40 (48.8%) had poor outcomes; regression used 75 patients with complete inflammatory-index data (35 events). At the univariable level, poor outcome was associated with higher NIHSS (median 15.5 vs. 8.0,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001), NLR, SII, and SIRI (all\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). In multivariable analysis, only age was independently associated with poor outcome (OR 1.09, 95% CI 1.02\u20131.16,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.008); the inflammatory indices were not, reflecting strong collinearity with NIHSS (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>s<\/jats:sub>\n                      \u202f=\u202f0.88). NIHSS showed the highest discrimination (AUC 0.754, 95% CI 0.636\u20130.858), followed by SII (0.716, 0.592\u20130.836) and NLR (0.695, 0.570\u20130.808). Adding any inflammatory index to NIHSS did not improve discrimination or reclassification (likelihood-ratio\n                      <jats:italic>p<\/jats:italic>\n                      \u202f\u2265\u202f0.40; \u0394AUC\u202f\u2264\u202f0.006; IDI\u202f\u2248\u202f0; no meaningful net benefit), and results were unchanged under multiple imputation, though the sample could not exclude a small effect.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Admission NLR, SII, and SIRI are associated with 6-month poor outcome after EVT, but this association is largely explained by stroke severity, with no detectable incremental value beyond NIHSS. These exploratory findings are hypothesis-generating and require prospective multicenter validation before clinical use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1819306","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:27:34Z","timestamp":1785817654000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Admission systemic inflammatory indices and 6-month functional outcome after endovascular thrombectomy for acute ischemic stroke: an exploratory single-center cohort study"],"prefix":"10.3389","volume":"17","author":[{"given":"Xiang","family":"Fang","sequence":"first","affiliation":[{"name":"Division 1, Neurology Department, Nanping First Hospital Affiliated to Fujian Medical University","place":["Nanping, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-fen","family":"Chen","sequence":"additional","affiliation":[{"name":"Division 1, Neurology Department, Nanping First Hospital Affiliated to Fujian Medical University","place":["Nanping, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Wu","sequence":"additional","affiliation":[{"name":"Division 1, Neurology Department, Nanping First Hospital Affiliated to Fujian Medical University","place":["Nanping, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taijian","family":"Liao","sequence":"additional","affiliation":[{"name":"Division 1, Neurology Department, Nanping First Hospital Affiliated to Fujian Medical University","place":["Nanping, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengmin","family":"Tong","sequence":"additional","affiliation":[{"name":"Division 1, Neurology Department, Nanping First Hospital Affiliated to Fujian Medical University","place":["Nanping, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biyu","family":"Xu","sequence":"additional","affiliation":[{"name":"Nanping First Hospital Affiliated to Fujian Medical University","place":["Nanping, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"S6","DOI":"10.1212\/WNL.0000000000012781","article-title":"Global epidemiology of stroke and access to acute ischemic stroke interventions","volume":"97","author":"Saini","year":"2021","journal-title":"Neurology"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1056\/NEJMoa1411587","article-title":"A randomized trial of intraarterial treatment for acute ischemic stroke","volume":"372","author":"Berkhemer","year":"2015","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1056\/NEJMoa1414905","article-title":"Randomized assessment of rapid endovascular treatment of ischemic stroke","volume":"372","author":"Goyal","year":"2015","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1016\/S0140-6736(16)00163-X","article-title":"Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials","volume":"387","author":"Goyal","year":"2016","journal-title":"Lancet"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1136\/neurintsurg-2018-014289","article-title":"Outcomes of endovascular thrombectomy in the elderly: a \u2018real-world\u2019 multicenter study","volume":"11","author":"Alawieh","year":"2019","journal-title":"J Neurointerv Surg"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s42466-023-00301-4","article-title":"Functional long-term outcome following endovascular thrombectomy in patients with acute ischemic stroke","volume":"6","author":"Rogalewski","year":"2024","journal-title":"Neurol Res Pract"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"2777","DOI":"10.1172\/JCI135530","article-title":"Immune responses to stroke: mechanisms, modulation, and therapeutic potential","volume":"130","author":"Iadecola","year":"2020","journal-title":"J Clin Invest"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1016\/S1474-4422(19)30078-X","article-title":"Global brain inflammation in stroke","volume":"18","author":"Shi","year":"2019","journal-title":"Lancet Neurol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"10566","DOI":"10.1038\/s41598-018-28646-w","article-title":"Reference values for white blood-cell-based inflammatory markers in 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treatment","volume":"11","author":"Lattanzi","year":"2021","journal-title":"Brain Sci"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"8","DOI":"10.4103\/tjem.tjem_198_23","article-title":"Unraveling the clinical significance and prognostic value of the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, systemic immune-inflammation index, systemic inflammation response index, and delta neutrophil index: an extensive literature review","volume":"24","author":"Islam","year":"2024","journal-title":"Turk J Emerg Med"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"11636","DOI":"10.1038\/s41598-017-11946-y","article-title":"Complete reperfusion is required for maximal benefits of mechanical thrombectomy in stroke patients","volume":"7","author":"Chamorro","year":"2017","journal-title":"Sci Rep"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"454","DOI":"10.3174\/ajnr.A2006","article-title":"Occurrence and predictors of futile recanalization 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studies","volume":"35","author":"Jickling","year":"2015","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1161\/CIRCRESAHA.116.309692","article-title":"Neutrophil extracellular traps in atherosclerosis and atherothrombosis","volume":"120","author":"D\u00f6ring","year":"2017","journal-title":"Circ Res"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"eaao6459","DOI":"10.1126\/scitranslmed.aao6459","article-title":"Targeted complement inhibition salvages stressed neurons and inhibits neuroinflammation after stroke in mice","volume":"10","author":"Alawieh","year":"2018","journal-title":"Sci Transl Med"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"e344","DOI":"10.1161\/STR.0000000000000211","article-title":"Guidelines for the early management of patients with acute ischemic stroke: 2019 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