{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T05:07:40Z","timestamp":1784092060107,"version":"3.55.0"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>\n                    This study explored the short-term effects of 50\u202fHz cerebellar intermittent theta burst stimulation (iTBS) on static balance and prefrontal cortical activation in patients with cerebellar ataxia (CA). Ten patients with CA (4 males; mean age, 57.6\u202f\u00b1\u202f9.1\u202fyears) underwent iTBS over the bilateral cerebellum for five consecutive days (8\u202fmin\/session, 80% active motor threshold); static balance was assessed using a Balance Trainer 4 (BT4) under eyes-open (EO) and eyes-closed (EC) conditions at baseline (V0), immediately post-intervention (V1), and 6\u202fweeks post-treatment (V2). Clinical scales (K-SARA, K-MBI, SF-36-K) and functional near-infrared spectroscopy (fNIRS) during a dual-task toe-tapping paradigm (motor\u202f+\u202fmental subtraction) were also administered to evaluate motor and cognitive responses. Significant, albeit transient, improvements in postural balance were observed at V1 relative to V0: under EO conditions, anterior\u2013posterior sway (\u0394Y) and total displacement (\u0394d) decreased significantly (\n                    <jats:italic>p<\/jats:italic>\n                    \u202f&amp;lt;\u202f0.05), and under EC conditions, medial\u2013lateral sway (\u0394X) also improved (\n                    <jats:italic>p<\/jats:italic>\n                    \u202f&amp;lt;\u202f0.05); however, these effects were not sustained at V2. Regarding safety, dizziness was the most frequently reported adverse event, occurring in 5 of 10 participants (50%); all events were mild\u2013moderate, transient, and resolved without treatment discontinuation. In conclusion, 50\u202fHz cerebellar iTBS was well tolerated and transiently enhanced postural stability in CA patients, and combined fNIRS monitoring demonstrated cortical engagement during cognitive-motor integration, supporting fNIRS as a real-time brain imaging biomarker for exploring the neurophysiological mechanisms underlying iTBS-induced modulation of the cerebello-fronto-cortical loop.\n                  <\/jats:p>","DOI":"10.3389\/fneur.2026.1826602","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T04:42:20Z","timestamp":1784090540000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility and preliminary signal of cerebellar intermittent theta burst stimulation for static balance in cerebellar ataxia: a pilot study"],"prefix":"10.3389","volume":"17","author":[{"given":"Sumin","family":"Lee","sequence":"first","affiliation":[{"name":"Cognitive Science Research Group, Korea Brain Research Institute","place":["Daegu, Republic of Korea"]},{"name":"Department of Artificial Intelligence, Kyungpook National University","place":["Daegu, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunhee","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, School of Medicine, Kyungpook National University","place":["Daegu, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjeon","family":"Cheong","sequence":"additional","affiliation":[{"name":"Cognitive Science Research Group, Korea Brain Research Institute","place":["Daegu, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihyeong","family":"Ro","sequence":"additional","affiliation":[{"name":"Cognitive Science Research Group, Korea Brain Research Institute","place":["Daegu, Republic of Korea"]},{"name":"Department of Biomedical Science, Kyungpook National University","place":["Daegu, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jungeun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kyungpook National University Chilgok Hospital","place":["Daegu, Republic of Korea"]},{"name":"Department of Neurology, School of Medicine, Kyungpook National University","place":["Daegu, Republic of Korea"]},{"name":"Brain Science and Engineering Institute, Kyungpook National University","place":["Daegu, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho-Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kyungpook National University Chilgok Hospital","place":["Daegu, Republic of Korea"]},{"name":"Department of Neurology, School of Medicine, Kyungpook National University","place":["Daegu, Republic of Korea"]},{"name":"Brain Science and Engineering Institute, Kyungpook National University","place":["Daegu, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minyoung","family":"Jung","sequence":"additional","affiliation":[{"name":"Cognitive Science Research Group, Korea Brain Research Institute","place":["Daegu, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s12311-008-0059-3","article-title":"Cerebellum predicts the future motor state","volume":"7","author":"Ebner","year":"2008","journal-title":"Cerebellum"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1007\/s12311-011-0331-9","article-title":"Roles of the cerebellum in motor control\u2014the diversity of ideas on cerebellar involvement in 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