{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T04:56:50Z","timestamp":1781672210778,"version":"3.54.5"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Carotid web (CaW) is a recognized risk factor for ischemic stroke, histopathologically classified as intimal fibromuscular dysplasia. However, clinical and imaging characteristics of CaW may vary across ethnic populations, and data from the Chinese population remain limited. This study aimed to investigate the clinical and computed tomography angiography (CTA) characteristics of CaW in Chinese stroke patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively reviewed CTA examinations of 9,220 patients at a single center in southern China from November 2005 to February 2021. Patients with CaW diagnosed on CTA were identified. Demographic data, clinical presentations, comorbidities, and CTA features including location, orientation, lumen dimensions, and stenosis severity were analyzed. Comparisons between cerebral infarction and non-cerebral infarction groups were performed using independent-sample\n                      <jats:italic>t<\/jats:italic>\n                      -tests and Fisher's exact test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 34 patients (32 males, 2 females; mean age 56.97 \u00b1 14.75 years) with 42 CaWs were identified (prevalence 0.37%). The majority of CaWs (37\/42, 88.1%) were located at the common carotid artery (CCA) bifurcation, with 5 (11.9%) at the internal carotid artery (ICA) bulb. Unilateral CaW was found in 26 patients (76.5%) and bilateral in 8 (23.5%). Cerebral infarction was the most common diagnosis (21\/34, 61.8%). The lumen diameter at the CaW site was significantly different between the cerebral infarction and non-infarction groups (8.97 \u00b1 2.34 mm vs. 6.80 \u00b1 1.90 mm,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.008). Hypertension was significantly more prevalent in the cerebral infarction group (76.2 vs. 23.1%,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.004). Mild stenosis (1%\u221230%) accounted for 64.7% of cases per NASCET criteria.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In the Chinese population, CaW predominantly affects males and tends to be unilateral, located at the CCA bifurcation. CaW-induced mild carotid stenosis constituted the majority of cases. CaW is an important risk factor for cryptogenic cerebral infarction. The lumen diameter at CaW sites and hypertension were significantly associated with cerebral infarction, highlighting the need for careful CTA evaluation and individualized management strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1828820","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T04:45:15Z","timestamp":1781671515000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and CT angiography characteristics of Chinese stroke patients with carotid web: a retrospective study"],"prefix":"10.3389","volume":"17","author":[{"given":"Zhuoman","family":"Chen","sequence":"first","affiliation":[{"name":"Department of General Practice, Shenzhen Second People's Hospital, Shenzhen","place":["Guangdong, China"]},{"name":"Department of General Practice, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen","place":["Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shenzhen Second People's Hospital, Shenzhen","place":["Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianfu","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The People's Hospital of Longhua, Shenzhen","place":["Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaming","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Shenzhen Second People's Hospital, Shenzhen","place":["Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yougang","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Radiology, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen","place":["Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of General Practice, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen","place":["Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siping","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Radiology, Shenzhen Second People's Hospital, Shenzhen","place":["Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijie","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shenzhen Second People's Hospital, Shenzhen","place":["Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3134","DOI":"10.1161\/STROKEAHA.117.019020","article-title":"Carotid web (intimal fibromuscular dysplasia) has high stroke recurrence risk and is amenable to stenting","volume":"48","author":"Haussen","year":"2017","journal-title":"Stroke."},{"key":"B2","doi-asserted-by":"publisher","first-page":"2134","DOI":"10.3174\/ajnr.A4431","article-title":"Carotid webs and recurrent ischemic strokes in the era of CT angiography","volume":"36","author":"Choi","year":"2015","journal-title":"AJNR Am J Neuroradiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"169","DOI":"10.5853\/jos.2025.00626","article-title":"Carotid web: an update focusing on its relationship with fibromuscular dysplasia and therapeutic strategy","volume":"27","author":"Zedde","year":"2025","journal-title":"J 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