{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T04:54:08Z","timestamp":1781844848303,"version":"3.54.5"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Intrasaccular devices such as SEAL\u2122 and WEB\u2122-SL are designed to disrupt aneurysmal flow. We present a new\n                      <jats:italic>in vitro<\/jats:italic>\n                      method for estimating neurointerventional devices\u2019 flow dynamics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Particle image velocimetry (PIV) method was used in a patient-specific middle cerebral artery (MCA) wide-neck bifurcation aneurysm (WNBA) model to measure velocity, residence time (RT), and vorticity strength (VS). Tested devices included 3 each of SEAL-BASE (6\u202f\u00d7\u202f2\u202fmm), SEAL-ARC (6\u202f\u00d7\u202f5\u202fmm), and WEB-SL (6\u202f\u00d7\u202f4\u202fmm).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twelve experiments were performed (3 unique devices per size and 3 controls); the mean RT was 0.042\u202f\u00b1\u202f0.006\u202fs (control) and increased with SEAL-BASE (0.387\u202f\u00b1\u202f0.128), SEAL-ARC (0.33\u202f\u00b1\u202f0.092), and WEB-SL (0.171\u202f\u00b1\u202f0.034) (all\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05 vs. control), and was longer in SEAL-BASE (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.046) and SEAL-ARC (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.041) than WEB-SL, with no difference between SEAL configurations (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.30). The VS decreased from 66.48\u202f\u00b1\u202f8.58 1\/s (control) to 14.06\u202f\u00b1\u202f2.80, 13.94\u202f\u00b1\u202f2.53, and 27.60\u202f\u00b1\u202f4.16 for SEAL-BASE, SEAL-ARC, and WEB-SL, respectively. The SEAL devices differed from WEB-SL (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.007, 0.006) but not from each other (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.52). Velocity magnitude dropped from 109.4\u202f\u00b1\u202f15.5\u202fmm\/s (control) to 12.42\u202f\u00b1\u202f3.8, 14.2\u202f\u00b1\u202f3.5, and 25.34\u202f\u00b1\u202f3.16 for SEAL-BASE, SEAL-ARC, and WEB-SL, respectively; greater reductions with SEAL-BASE (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.006) and SEAL-ARC (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.007) versus WEB-SL, with no difference between the two SEAL configurations (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.29).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both SEAL configurations achieved greater flow reduction compared to the WEB-SL of similar width in the same aneurysm model. Results highlight the unique utilization of the PIV method for the mechanistic decoupling of momentum transfer into the aneurysm sac resulting from intra-aneurysmal mesh structures and point toward their potential for further neurointerventional device optimization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1830746","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T04:28:53Z","timestamp":1781843333000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["In-vitro flow assessment study of intra-saccular endovascular devices for brain aneurysm treatment: SEAL\u2122 vs. WEB\u2122"],"prefix":"10.3389","volume":"17","author":[{"given":"Hamid","family":"Mansouri","sequence":"first","affiliation":[{"name":"Department of Mechanical, Industrial, and Manufacturing Engineering, University of Toledo","place":["Toledo, OH, United 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States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian T.","family":"Jankowitz","sequence":"additional","affiliation":[{"name":"Hackensack Meridian Neuroscience Institute at JFK University Medical Center","place":["Edison, NJ, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Altschul","sequence":"additional","affiliation":[{"name":"Montefiore Einstein Advanced Care Neurosurgery","place":["Elmsford, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Pabon","sequence":"additional","affiliation":[{"name":"Centro Comercial Cauca Centro, Universidad de Antioquia","place":["Antioquia, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pervinder","family":"Bhogal","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, The Royal London Hospital, Barts NHS Trust","place":["London, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Wolfe","sequence":"additional","affiliation":[{"name":"Aurora Neuroscience Innovation","place":["Milwaukee, WI, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgard L.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Neuro Endovascular Surgery, McLeod Medical Center","place":["Florence, SC, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aamir","family":"Badruddin","sequence":"additional","affiliation":[{"name":"Powers Health Medical Group, Neurosurgery and Spinal Surgery","place":["Munster, IN, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laila","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Galaxy Therapeutics Inc.","place":["Milpitas, CA, United 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