{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T15:41:19Z","timestamp":1789486879441,"version":"build-2803163510"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the cerebral blood flow regulation function in migraine patients using transcranial Doppler (TCD), and to explore the potential mechanism behind the increased risk of cerebral infarction in migraine patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Compare cerebral blood flow regulation function between migraine patients and healthy volunteers. Compare cerebral blood flow regulation function among migraine patient groups with different grades of right\u2013left shunt (RLS). Screen the influencing factors of cerebral blood flow regulation function in migraine patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Migraine patients exhibited decreased phase difference and breath-holding index (BHI), and increased gain (all\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). Migraine patients with large amount of RLS showed decreased phase difference (right side) and BHI compared to those without RLS (all\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). Age was negatively correlated with gain and positively correlated with phase difference (left side) in migraine patients; RLS grade was negatively correlated with phase difference (right side) and BHI; onset age was negatively correlated with gain and positively correlated with phase difference (all\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). Onset age was a positive moderator of phase difference (right) and a negative moderator of gain (left); RLS grade was a negative moderator of BHI (all\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The cerebral blood flow regulation function is impaired in migraine patients. Migraine patients with large amount of RLS exhibit more severe impairment of cerebral blood flow regulation compared to those without RLS. Younger age at onset and a higher RLS flow rate may be risk factors for impaired cerebral blood flow regulation in migraine patients. Impaired cerebral blood flow regulation function may be a potential mechanism underlying the increased risk of cerebral infarction in migraine patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1832591","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T13:30:25Z","timestamp":1789479025000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Preliminary study on the cerebral blood flow regulation function in migraine patients using transcranial Doppler ultrasound"],"prefix":"10.3389","volume":"17","author":[{"given":"Yanan","family":"Zhang","sequence":"first","affiliation":[{"name":"Stroke Center, Central Hospital of Dalian University of Technology","place":["Dalian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongling","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Central Hospital of Dalian University of Technology","place":["Dalian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Furong","family":"Li","sequence":"additional","affiliation":[{"name":"Stroke Center, Central Hospital of Dalian University of Technology","place":["Dalian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junmin","family":"Tao","sequence":"additional","affiliation":[{"name":"Stroke Center, Central Hospital of Dalian University of Technology","place":["Dalian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Central Hospital of Dalian University of Technology","place":["Dalian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhan","family":"Liu","sequence":"additional","affiliation":[{"name":"Stroke Center, Central Hospital of Dalian University of Technology","place":["Dalian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Dong","sequence":"additional","affiliation":[{"name":"Stroke Center, Central Hospital of Dalian University of Technology","place":["Dalian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","article-title":"Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the global burden of disease study 2019","volume":"396","year":"2020","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e010307","DOI":"10.1161\/CIRCOUTCOMES.123.010307","article-title":"Association of traditional and nontraditional risk factors in the development of strokes among young adults by sex and age group: a retrospective case-control study","volume":"17","author":"Leppert","year":"2024","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/s41983-022-00562-x","article-title":"Migraine as a risk factor for ischemic stroke: a systematic review and meta-analysis of cohort studies","volume":"58","author":"Adnyana","year":"2022","journal-title":"Egypt J Neurol Psychiatry Neurosurg"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1177\/0271678x18794835","article-title":"Impaired cerebral autoregulation and neurovascular coupling in middle cerebral artery stroke: influence of severity?","volume":"39","author":"Salinet","year":"2019","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"2605","DOI":"10.1161\/STROKEAHA.118.022481","article-title":"Dynamic cerebral autoregulation is an independent functional outcome predictor of mild acute ischemic stroke","volume":"49","author":"Chi","year":"2018","journal-title":"Stroke"},{"key":"ref6","first-page":"241","article-title":"Correlation between cerebrovascular reserve and early neurological deterioration in lacunar infarction","volume":"37","author":"Li","year":"2016","journal-title":"J Int Geriatrics"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.joca.2020.10.004","article-title":"Visual analogue scale has higher assay sensitivity than WOMAC pain in detecting between-group differences in treatment effects: a meta-epidemiological study","volume":"29","author":"da Costa","year":"2021","journal-title":"Osteoarthr Cartil"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1111\/j.1468-1331.2012.03793.x","article-title":"Prevalence and extent of right-to-left shunt in migraine:a survey of 217 Chinese patients","volume":"19","author":"Yang","year":"2012","journal-title":"Eur J Neurol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1177\/0271678X15626425","article-title":"International cerebral autoregulation research N. Transfer function analysis of dynamic cerebral autoregulation: a white paper from the international cerebral autoregulation research network","volume":"36","author":"Claassen","year":"2016","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1038\/nrneurol.2013.192","article-title":"Cortical spreading depression and migraine","volume":"9","author":"Charles","year":"2013","journal-title":"Nat Rev Neurol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1177\/0333102411427599","article-title":"Migraine and hypercoagulable slates in ischemic stroke","volume":"31","author":"Mart\u00ednez-Sanchez","year":"2011","journal-title":"Cephalalgia"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1007\/s10072-013-1542-2","article-title":"Increased fibrinogen, D-dimer and galectin-3 levels in patients with migraine","volume":"35","author":"Yucel","year":"2014","journal-title":"Neurol Sci"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1212\/WNL.0b013e31826170ce","article-title":"Endothelial progenitor cells: a new key for endothelial dysfunction in migraine","volume":"79","author":"Rodriguez-Osorio","year":"2012","journal-title":"Neurology"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/head.13229","article-title":"Risk of stroke associated with use of estrogen containing contraceptives in women with migraine:a systematic review","volume":"58","author":"Sheikh","year":"2018","journal-title":"Headache"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.1161\/strokeaha.116.016133","article-title":"Migraine and cerebrovascular atherosclerosis in patients with ischemic stroke","volume":"48","author":"van Os","year":"2017","journal-title":"Stroke"},{"key":"ref16","volume-title":"Cerebrovascular imaging study in patients with migraine complicated with ischemic stroke","author":"Zhang","year":"2022"},{"key":"ref17","first-page":"934","article-title":"Relationship between migraine and abnormal white matter signals on MRI: a meta-analysis","volume":"13","author":"Li","year":"2014","journal-title":"Chin J Neuromed"},{"key":"ref18","article-title":"Related factors of white matter lesions in migraine","volume":"35","author":"Pan","year":"2022","journal-title":"J Clin Neurol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"2563","DOI":"10.1001\/jama.2009.932","article-title":"Migraine headache in middle age and late-life brain infarcts","volume":"301","author":"Scher","year":"2009","journal-title":"JAMA"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1161\/CIR.0b013e3181daf630","article-title":"Migraine headache and the patent foramen ovale","volume":"121","author":"Gersony","year":"2010","journal-title":"Circulation"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s10072-015-2163-8","article-title":"Migraine with aura and patent foramen ovale: myth or reality?","volume":"36","author":"Finocchi","year":"2015","journal-title":"Neurol Sci"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"288","DOI":"10.3969\/j.issn.1673-5765.2016.04.009","article-title":"Compromised dynamic cerebral autoregulation in patients with a right-to-left shunt: a potential mechanism of migraine and cryptogenic stroke","volume":"11","author":"Guo","year":"2016","journal-title":"Chin J Stroke"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1007\/s11910-013-0426-4","article-title":"Migraine and patent foramen ovale","volume":"14","author":"Ailani","year":"2014","journal-title":"Curr Neurol Neurosci Rep"},{"key":"ref24","volume-title":"The effect of transcatheter closure on cerebral autoregulation in migraine patients with patent foramen ovale and its underlying mechanism. 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