{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:02:01Z","timestamp":1785322921962,"version":"3.55.0"},"reference-count":9,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Mechanical thrombectomy is the standard of care for acute ischemic stroke due to large vessel occlusions. Conventional self-expanding stent retrievers (SE-SRs) deploy with fixed radial force, whereas Tigertriever is a radially adjustable operator-controlled device that allows tailored expansion and modulation of vessel wall pressure. This study systematically compared the efficacy and safety of Tigertriever with SE-SRs in large vessel occlusion thrombectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A systematic search of PubMed, Cochrane, Embase, and\n                      <jats:uri>ClinicalTrials.gov<\/jats:uri>\n                      was conducted in line with PRISMA guidelines. Eligible studies compared Tigertriever with SE-SRs, with outcomes including rate of successful reperfusion (mTICI \u2265 2b), procedural adverse events (PAEs; composite of procedure-related vasospasm, dissection, perforation, distal emboli, emboli to new territory, and subarachnoid hemorrhage), symptomatic intracranial hemorrhage (sICH) within 24\u202fh post-procedure, functional independence (mRS 0\u20132) at 90\u202fdays and all-cause mortality at 90\u202fdays. Odds ratios (OR) with 95% confidence intervals (CI) were pooled using the Mantel\u2013Haenszel method. Risk of bias was assessed using ROBINS-I, and certainty of evidence using the GRADE approach.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Three retrospective cohort studies with 476 patients (210 Tigertriever, 266 SE-SR) were included. Target intracranial vessel occlusion locations were internal carotid artery (ICA), middle cerebral artery (MCA) M1, MCA M2 and basilar artery. Tigertriever achieved significantly higher successful reperfusion compared with SE-SRs [82.8% vs. 77.8%; OR 1.74 (1.07\u20132.83);\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.03;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      =\u202f0%]. There was a trend towards fewer PAEs, but the difference did not reach statistical significance [17.1% vs. 27.4%; OR 0.72 (0.44\u20131.16);\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.17;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      =\u202f0%]. Rates of sICH within 24\u202fh, functional independence at 90\u202fdays and mortality at 90\u202fdays were similar. The overall risk of bias was low to moderate. GRADE-assessed certainty for different outcomes was overall moderate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this exploratory meta-analysis of retrospective cohorts, Tigertriever was associated with significantly higher reperfusion rates, while safety and functional outcomes appeared comparable between groups. Findings should be interpreted cautiously given study-level heterogeneity, limited sample size, inconsistent procedural reporting, and the observational nature of included studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic review registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/www.crd.york.ac.uk\/PROSPERO\/view\/CRD420251161491<\/jats:ext-link>\n                      . The protocol for this meta-analysis was registered on PROSPERO. ID: CRD420251161491.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1839128","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T14:51:00Z","timestamp":1782917460000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Radially adjustable Tigertriever demonstrates higher reperfusion compared to self-expanding stent-retrievers during mechanical thrombectomy of large vessel occlusions: a systematic review and meta-analysis"],"prefix":"10.3389","volume":"17","author":[{"given":"Zain","family":"Tariq","sequence":"first","affiliation":[{"name":"Department of Neurointervention, Mercy Health St. Vincent Medical Center","place":["Toledo, OH, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faizan","family":"Shahzad","sequence":"additional","affiliation":[{"name":"Department of Neurology, Rawalpindi Medical University","place":["Rawalpindi, Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor E.","family":"Jannat","sequence":"additional","affiliation":[{"name":"Department of Neurology, Rawalpindi Medical University","place":["Rawalpindi, Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tallal Mushtaq","family":"Hashmi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Rawalpindi Medical University","place":["Rawalpindi, Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonesh","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Neurointervention, Dignity Health Mercy Medical Center","place":["Redding, CA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"AlMajali","sequence":"additional","affiliation":[{"name":"Department of Neuroendovascular Surgery, Ochsner Lafayette General","place":["Lafayette, LA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qasim","family":"Bashir","sequence":"additional","affiliation":[{"name":"Department of Neuroendovascular Surgery, Punjab Institute of Neurosciences","place":["Lahore, Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Saver","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, University of California, Los Angeles","place":["Los Angeles, CA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Besher","family":"Shami","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Aleppo","place":["Aleppo, Syria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Chaudhari","sequence":"additional","affiliation":[{"name":"Department of Neurointervention, Mercy Health St. Vincent Medical Center","place":["Toledo, OH, United States"]},{"name":"Department of Neurointervention, Dignity Health Mercy Medical Center","place":["Redding, CA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1016\/S0140-6736(16)00163-X","article-title":"Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials","volume":"387","author":"Goyal","year":"2016","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1177\/15910199221084481","article-title":"A review of mechanical thrombectomy techniques for acute ischemic stroke","volume":"29","author":"Munoz","year":"2023","journal-title":"Interv Neuroradiol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1161\/STROKEAHA.121.034436","article-title":"New class of radially adjustable stentrievers for acute ischemic stroke: primary results of the multicenter TIGER trial","volume":"52","author":"Gupta","year":"2021","journal-title":"Stroke"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.jclinepi.2021.08.022","article-title":"Cochrane's risk of bias tool for non- randomized studies (ROBINS-I) is frequently misapplied: a methodological systematic review","volume":"140","author":"Igelstr\u00f6m","year":"2021","journal-title":"J Clin Epidemiol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1177\/15910199251380920","article-title":"Comparison of mechanical thrombectomy with Tigertriever versus solitaire X stent retriever in real-world practice: a matched-pair retrospective analysis","author":"Vu","year":"2025","journal-title":"Interv Neuroradiol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"247","DOI":"10.2176\/jns-nmc.2024-0297","article-title":"Comparison of the Tigertriever and self-expanding stent retrievers for mechanical thrombectomy of acute ischemic stroke: a single-center experience","volume":"65","author":"Shindo","year":"2025","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1032307","DOI":"10.3389\/fneur.2022.103230","article-title":"Mechanical thrombectomy of large vessel occlusion using adjustable vs. self-expanding stent-retriever-comparison of Tigertriever device with stent-like stent-retrievers: a propensity score analysis","volume":"13","author":"Piasecki","year":"2023","journal-title":"Front Neurol"}],"updated-by":[{"DOI":"10.3389\/fneur.2026.1939142","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000}}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2026.1839128\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T10:21:43Z","timestamp":1785320503000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2026.1839128\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":9,"alternative-id":["10.3389\/fneur.2026.1839128"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2026.1839128","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,1]]},"article-number":"1839128"}}