{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T05:00:15Z","timestamp":1781067615092,"version":"3.54.1"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Focusing on patients with epilepsy and left-sided epileptogenic foci, this study aimed to clarify language lateralization differences from healthy individuals, explore Broca\u2019s\/Wernicke\u2019s area lateralization and dominant hemisphere shift, and construct a laterality index\u2013activation map combined scheme. It provides a theoretical basis for optimizing epilepsy surgery and reducing postoperative language impairment risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively studied 36 patients with left-sided epileptogenic foci and 45 healthy controls (2018\u20132023, Hebei Medical University Second Hospital). After preprocessing rs-fMRI data, 12 bilateral language-related seed points were selected to calculate functional connectivity and generate activation maps. We further computed two types of laterality indexes: the global laterality index (LI) reflecting overall whole-brain language lateralization, and the regional LI assessing independent lateralization of Broca\u2019s area (6 frontal seed points) and Wernicke\u2019s area (6 temporal seed points). The Kappa coefficient was used to analyze the consistency between different methods, and SEEG cortical stimulation (only performed in surgical candidates) combined with postoperative follow-up was applied to verify clinical reliability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Non-classical language dominance was higher in epilepsy (69.4% vs. 45.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.024), especially in Wernicke\u2019s area (81.8% vs. Broca\u2019s 50.0%). Laterality index\u2013activation map consistency was 83.3% (Kappa\u202f=\u202f0.586); regional laterality index\u2013activation map consistency was 75.0% (Kappa\u202f=\u202f0.40). SEEG stimulation and surgical verification confirmed that the left Broca\u2019s area retained core language function, whereas the left Wernicke\u2019s area showed significant functional impairment (only 10.0% positive stimulation rate, and no language deficits occurred after partial resection in 6 patients).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Left-sided epilepsy patients show language lateralization remodeling, with Wernicke\u2019s area more prone to shift. Bilateral language dominance does not equate to equal functional contribution; the left Broca\u2019s area retains core motor language function and requires priority protection in all epilepsy surgeries involving the left frontotemporal lobe, especially left frontal lobe epileptogenic focus resection. The combined laterality index\u2013activation map scheme reliably supports preoperative language lateralization, optimizes surgery, and reduces language impairment risk, with clinical value.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1839830","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T04:29:00Z","timestamp":1781065740000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Application value of resting-state fMRI in preoperative lateralization of language areas in epilepsy with left-sided epileptogenic foci"],"prefix":"10.3389","volume":"17","author":[{"given":"Zihao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, The Second Hospital of Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianqi","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The Second Hospital of Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The Second Hospital of Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaning","family":"Sun","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Hebei Province","place":["Shijiazhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The Second Hospital of Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The Second Hospital of Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1093\/brain\/awac150","article-title":"Disorganization of language and working memory systems in frontal versus temporal lobe epilepsy","volume":"146","author":"Caciagli","year":"2023","journal-title":"Brain"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e64876","DOI":"10.1371\/journal.pone.0064876","article-title":"Associations between handedness and cerebral lateralisation for language: a comparison of three measures in children","volume":"8","author":"Groen","year":"2013","journal-title":"PLoS One"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1136\/jnnp-2013-305659","article-title":"Can fMRI safely replace the Wada test for preoperative assessment of language lateralisation? 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