{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T04:46:14Z","timestamp":1785732374877,"version":"3.56.0"},"reference-count":52,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to construct and validate a nomogram for the intuitive prediction of 90-day unfavorable outcomes in patients with minor ischemic stroke who underwent intravenous thrombolysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Data were extracted from the Multicenter Clinical Trial of Revascularization Treatment for Acute Ischemic Stroke (TRAIS) study. Multivariable logistic regression was used to identify independent factors associated with 90-day unfavorable outcomes (modified Rankin Scale [mRS] score 2\u20136) in patients with minor ischemic stroke (National Institutes of Health Stroke Scale [NIHSS] score 0\u20135) receiving intravenous thrombolysis. A nomogram (designated as SPRIN\n                      <jats:sub>2<\/jats:sub>\n                      D) was developed based on the final prediction model, incorporating 6 key variables: NIHSS score, functional disability, systolic blood pressure, neutrophil count, international normalized ratio and renal dysfunction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1,438 eligible patients were enrolled and randomly assigned to a derivation cohort (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f1,007) and a validation cohort (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f431). In the overall cohort, the median age was 65\u202fyears (interquartile range, 56\u201373); 67.94% of participants were male, and the median admission NIHSS score of 2 (interquartile range, 1\u20134). The SPRIN\n                      <jats:sub>2<\/jats:sub>\n                      D nomogram exhibited robust performance in predicting 90-day unfavorable outcomes in minor ischemic stroke patients treated with intravenous thrombolysis. The area under the curve was 0.784 (95% confidence interval [CI], 0.744\u20130.822) in the derivation cohort and 0.776 (95% CI, 0.716\u20130.835) in the validation cohort. Moreover, the SPRIN\n                      <jats:sub>2<\/jats:sub>\n                      D nomogram demonstrated superior discriminative ability compared with other existing prognostic models for acute ischemic stroke and minor ischemic stroke.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The SPRIN\n                      <jats:sub>2<\/jats:sub>\n                      D nomogram is a stable and promising tool for predicting 90-day unfavorable outcomes in minor ischemic stroke patients treated with intravenous thrombolysis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1841196","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T04:25:54Z","timestamp":1785731154000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["SPRIN2D nomogram: predicting 90-day unfavorable outcomes in patients with minor ischemic stroke receiving intravenous thrombolysis"],"prefix":"10.3389","volume":"17","author":[{"given":"Jiao","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghui","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingcan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyong","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Wuhan Hankou Hospital","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jichuan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurology, People\u2019s Hospital of Dongxihu District","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hubei Provincial Hospital of Integrated Chinese and Western Medicine, Hubei University of Chinese Medicine","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Union 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