{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T05:24:43Z","timestamp":1786944283786,"version":"build-2736575974"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite available diagnostic and therapeutic options, a major unmet need persists in migraine care. This study applied artificial intelligence (AI) to extract structured insights from routine care and assess migraine burden, diagnosis, and treatment in T\u00fcrkiye.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The T\u00fcrkiye Migraine Registry Study was a retrospective, observational study across 23 hospitals and clinics in eight cities. Anonymized electronic health records (EHRs) of 11,023 adults treated between January 2021 and October 2023 were analyzed. A validated AI framework with natural language processing and machine learning extracted demographics, comorbidities, imaging, and prescriptions. Descriptive statistics summarized outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 90,381 neurology patients, 16,751 (18.5%) had migraine or suspected migraine; 11,023 met inclusion. Only 46.9% carried an ICD-10 migraine code, while 53.1% were coded under other headache syndromes yet frequently received migraine-specific therapies. The cohort was 73% female, mean age 41.5. Neuroimaging was frequent (58.7% MRI, 15.2% CT), and 18.4% visited emergency care. Preventive therapy was prescribed to 63.7%, mainly antidepressants (31.4%) and beta-blockers (19.4%). OnabotulinumtoxinA and CGRP monoclonal antibodies were used in 10.3 and 3.4%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AI-assisted EHR analysis revealed underdiagnosis, high imaging use, and limited adoption of mechanism-specific preventives in T\u00fcrkiye, underscoring the need for improved diagnostic accuracy and broader access to modern therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1848551","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T04:36:26Z","timestamp":1786941386000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Real-world evidence on migraine treatment in routine clinical practice: insights from the T\u00fcrkiye migraine registry study using artificial intelligence algorithms"],"prefix":"10.3389","volume":"17","author":[{"given":"P\u0131nar","family":"Yal\u0131nay Dikmen","sequence":"first","affiliation":[{"name":"Department of Neurology, Acibadem Ali Aydinlar University School of Medicine","place":["Istanbul, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif Ilgaz","family":"Aydinlar","sequence":"additional","affiliation":[{"name":"Department of Neurology, Acibadem Ali Aydinlar University School of Medicine","place":["Istanbul, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seda N.","family":"Dumlu","sequence":"additional","affiliation":[{"name":"Department of Computer Engineering, Faculty of Engineering and Natural Sciences, Acibadem Mehmet Ali Aydinlar University","place":["Istanbul, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tugay","family":"Onal","sequence":"additional","affiliation":[{"name":"Pfizer T\u00fcrkiye","place":["Istanbul, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salih","family":"Gumru","sequence":"additional","affiliation":[{"name":"Pfizer T\u00fcrkiye","place":["Istanbul, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efe","family":"Onganer","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Family Medicine, Acibadem Mehmet Ali Aydinlar University School of Medicine","place":["Istanbul, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Loleyt","sequence":"additional","affiliation":[{"name":"Traverse Health","place":["Amsterdam, Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/s41582-021-00509-5","article-title":"Diagnosis and management of migraine in ten 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