{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:10:18Z","timestamp":1788952218881,"version":"build-2803163510"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intravenous tirofiban administered before endovascular treatment (EVT) did not improve 90-day outcomes compared to placebo in the RESCUE BT trial, and sex-specific heterogeneity remained uncertain. In this study, we aimed to evaluate the association between sex and tirofiban administration before EVT among patients enrolled in the RESCUE BT trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      This\n                      <jats:italic>post hoc<\/jats:italic>\n                      analysis used data from the RESCUE BT trial, which enrolled 948 patients with large vessel occlusion (LVO). Patients received intravenous tirofiban or a placebo before EVT. Comparisons between different groups were conducted using logistic regression. Additionally, the interaction between sex and treatment was tested. The primary effectiveness outcome was a modified Rankin Scale (mRS) score of 0\u20132 at 90\u202fdays; safety outcomes included symptomatic intracranial hemorrhage (sICH) within 48\u202fh and mortality at 90\u202fdays.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 948 patients, 391 (41.2%) were women. The interaction between sex and treatment for a 90-day mRS score of 0\u20132 was not statistically significant (\n                      <jats:italic>P<\/jats:italic>\n                      for interaction\u202f=\u202f0.103). However, in the tirofiban arm, women were less likely to achieve an mRS score of 0\u20132 at 90\u202fdays (adjusted odds ratio (aOR), 0.57; 95% confidence interval (CI), 0.36\u20130.90;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.02) compared to men. In analyses stratified by sex, tirofiban was not associated with improved functional outcomes compared to placebo in either women or men. No sex-related differences were observed in symptomatic intracranial hemorrhage within 48\u202fh or mortality at 90\u202fdays.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this exploratory analysis, no significant interaction between sex and treatment was identified, indicating that the association between tirofiban and 90-day outcomes did not differ by sex. Although women in the tirofiban arm had lower odds of achieving an mRS score of 0\u20132 at 90\u202fdays than men, this finding should be interpreted as hypothesis-generating and warrants further validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1850978","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:16:29Z","timestamp":1788948989000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between tirofiban administration and sex in outcomes following endovascular treatment for large vessel occlusion stroke"],"prefix":"10.3389","volume":"17","author":[{"given":"Sheng","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Neurology, Renhuai People's Hospital","place":["Zunyi, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjiao","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Neurology, Renhuai People's Hospital","place":["Zunyi, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Lanzhou University Second Hospital","place":["Lanzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoxuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University)","place":["Chongqing, China"]},{"name":"Department of Neurology, The 908th Hospital of Chinese People\u2019s Liberation Army Joint Logistic Support Force","place":["Nanchang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University)","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rugang","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Renhuai People's Hospital","place":["Zunyi, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Renhuai People's Hospital","place":["Zunyi, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Neurology, Renhuai People's Hospital","place":["Zunyi, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Renhuai People's Hospital","place":["Zunyi, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Renhuai People's Hospital","place":["Zunyi, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Renhuai People's Hospital","place":["Zunyi, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Renhuai People's Hospital","place":["Zunyi, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guojian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University)","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University)","place":["Chongqing, China"]},{"name":"Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chawen","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxing","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University)","place":["Chongqing, China"]},{"name":"Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianjin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Renhuai People's Hospital","place":["Zunyi, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingrui","family":"Zhou","sequence":"additional","affiliation":[{"name":"The First Clinical Medical School, Hubei University of Chinese Medicine","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1046\/j.1538-7836.2003.00040.x","article-title":"Gender differences in coagulation and fibrinolysis in white subjects with acute ischemic stroke","volume":"1","author":"Kain","year":"2003","journal-title":"J Thromb Haemost"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/nrn846","article-title":"Oestrogen as a neuroprotective hormone","volume":"3","author":"Behl","year":"2002","journal-title":"Nat Rev Neurosci"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1161\/STROKEAHA.114.007985","article-title":"Factors influencing sex differences in poststroke functional 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