{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:47:27Z","timestamp":1782283647123,"version":"3.54.5"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>\n                    Cognitive impairment is a significant health problem worldwide, closely associated with the status of gut microbiota. Our recent research has revealed the\n                    <jats:italic>Blautia faecis<\/jats:italic>\n                    and\n                    <jats:italic>Blautia massiliensis<\/jats:italic>\n                    exhibit opposing associations with cognitive function in children with Down syndrome clinically characterized by cognitive dysfunction. However, the role and mechanisms of\n                    <jats:italic>Blautia faecis<\/jats:italic>\n                    and\n                    <jats:italic>Blautia massiliensis<\/jats:italic>\n                    in cognitive function remain unknown. Therefore, we gavaged C57BL\/6 male mice with commercially available\n                    <jats:italic>Blautia faecis<\/jats:italic>\n                    and\n                    <jats:italic>Blautia massiliensis<\/jats:italic>\n                    for 3\u202fweeks and assessed cognitive function using the novel object recognition and Y-maze test.\n                    <jats:italic>Blautia faecis<\/jats:italic>\n                    administration impaired cognitive performance, whereas\n                    <jats:italic>Blautia massiliensis<\/jats:italic>\n                    treatment improved it, with these effects observed predominantly in the absence of antibiotic pretreatment. Furthermore, we observed that administration of\n                    <jats:italic>Blautia faecis<\/jats:italic>\n                    increased the number of microglia, resulting in a twofold increase in cell count relative to WT control. Hippocampal pro-inflammatory cytokines were significantly upregulated in the\n                    <jats:italic>Blautia faecis<\/jats:italic>\n                    group, while\n                    <jats:italic>Blautia massiliensis<\/jats:italic>\n                    suppressed these neuroinflammatory responses. Notably,\n                    <jats:italic>Blautia massiliensis<\/jats:italic>\n                    produces approximately six times more acetate than\n                    <jats:italic>Blautia faecis<\/jats:italic>\n                    . Consequently, our findings indicate that\n                    <jats:italic>Blautia massiliensis<\/jats:italic>\n                    enhances cognitive function whereas\n                    <jats:italic>Blautia faecis<\/jats:italic>\n                    impairs it, and we speculate that differential acetate production may contribute to these opposing effects.\n                  <\/jats:p>","DOI":"10.3389\/fneur.2026.1854107","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:56:36Z","timestamp":1782280596000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Opposite regulatory effects of Blautia massiliensis and Blautia faecis on cognitive function, microglia and metabolite acetic acid in mice"],"prefix":"10.3389","volume":"17","author":[{"given":"Minghui","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pediatric, Peking University People\u2019s Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory & Institute of Clinical Molecular Biology, Peking University People\u2019s Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory & Institute of Clinical Molecular Biology, Peking University People\u2019s Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatric, Peking University People\u2019s Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pediatric, Peking University People\u2019s Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuyang","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Pediatric, Peking University People\u2019s Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuran","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pediatric, Peking University People\u2019s Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory & Institute of Clinical Molecular Biology, Peking University People\u2019s Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingzhu","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pediatric, Peking University People\u2019s 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