{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T05:06:05Z","timestamp":1784696765419,"version":"3.55.0"},"reference-count":67,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["LM012870"],"award-info":[{"award-number":["LM012870"]}]},{"name":"NIH","award":["HD08321"],"award-info":[{"award-number":["HD08321"]}]},{"name":"NIH","award":["HD38985"],"award-info":[{"award-number":["HD38985"]}]},{"name":"NIH","award":["HD061222"],"award-info":[{"award-number":["HD061222"]}]},{"name":"NIH","award":["RR019478"],"award-info":[{"award-number":["RR019478"]}]},{"name":"NIH","award":["U54"],"award-info":[{"award-number":["U54"]}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Individuals with neurodevelopmental disorders (NDDs) are at increased risk of having sleep difficulties. A variety of sleep problems have been reported in Angelman syndrome (AS), Prader-Willi syndrome (PWS), and Rett syndrome (RTT). The present study intended to expand an earlier characterization of sleep difficulties in a large AS, PWS, and RTT sample by analyzing subscales of standardized sleep questionnaires.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Scores from children (2\u201318\u202fyears) with AS (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f74), PWS (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f90) or RTT (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f241) on components of the Children\u2019s Sleep Habits Questionnaire (CSHQ), the Sleep-Related Breathing Disorder (SRBD) scale, and the Pediatric Daytime Sleepiness Scale (PDSS) were compared between NDDs and with those from a group of neurotypical siblings (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f282). Additional comparisons of scores after a 12-month follow-up evaluation, in a subset of individuals, were also performed. Data were analyzed using nonparametric tests and, for changes over time, both cross-sectionally and longitudinally.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Comparisons with neurotypical children showed that night waking and snoring were increased in the three NDDs while parasomnias and daytime sleepiness only in AS and RTT. Children with RTT also had the highest scores on measures of disordered breathing. At the 12-month follow-up, scores decreased in neurotypical children but had variable courses in the NDDs, with increased disordered breathing scores characterizing AS and RTT. There was high agreement among disordered breathing measures, but not among daytime sleepiness scales. Overall, CSHQ scores were relatively stable within NDDs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Sleep questionnaires revealed disorder-specific profiles of sleep problems that could assist in their identification and management. The CSHQ and the SRBD, including their subscales, appear to be consistent measures particularly for sleep-disordered breathing and, therefore, suitable for clinical and research use in severe NDDs. Follow-up studies should expand the range of instruments to include objective measures in the characterization of sleep abnormalities in AS, PWS, and RTT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1854819","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:40:44Z","timestamp":1784695244000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Profiles of sleep disturbances in Angelman, Prader-Willi, and Rett syndromes: analysis of standardized questionnaires"],"prefix":"10.3389","volume":"17","author":[{"given":"Lindsay M.","family":"Oberman","sequence":"first","affiliation":[{"name":"National Institute of Mental Health Intramural Research Program, National Institutes of Health","place":["Bethesda, MD, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia J.","family":"Veatch","sequence":"additional","affiliation":[{"name":"Division of Medical Informatics, Department of Psychiatry and Behavioral Sciences, University of Kansas Medical Center","place":["Kansas, KS, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarika U.","family":"Peters","sequence":"additional","affiliation":[{"name":"Vanderbilt Kennedy Center, Department of Pediatrics, Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Vanderbilt University","place":["Nashville, TN, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter E.","family":"Kaufmann","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, School of Medicine, Emory University","place":["Atlanta, GA, United States"]},{"name":"Department of Neurology, Boston Children\u2019s Hospital","place":["Boston, MA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1007\/s13311-020-00982-8","article-title":"Neurodevelopmental disorders commonly presenting with sleep disturbances","volume":"18","author":"Shelton","year":"2021","journal-title":"Neurotherapeutics"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1046\/j.1365-2788.1998.00111.x","article-title":"A questionnaire survey of sleep and night-time behaviour in a community-based sample of adults with intellectual disability","volume":"42","author":"Brylewski","year":"1998","journal-title":"J Intellect Disabil Res"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.cppeds.2003.10.003","article-title":"Sleep problems","volume":"34","author":"Owens","year":"2004","journal-title":"Curr Probl Pediatr Adolesc Health Care"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.pop.2008.06.003","article-title":"Classification and epidemiology of childhood sleep disorders","volume":"35","author":"Owens","year":"2008","journal-title":"Prim Care"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.chc.2020.08.002","article-title":"Classification and epidemiology of sleep disorders in children and adolescents","volume":"30","author":"Trosman","year":"2021","journal-title":"Child Adolesc Psychiatr Clin N Am"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3390\/children4090082","article-title":"Sleep disorders in childhood neurogenetic disorders","volume":"4","author":"Dosier","year":"2017","journal-title":"Children (Basel)"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s13229-021-00426-w","article-title":"Sleep disorders in rare genetic syndromes: a meta-analysis of prevalence and profile","volume":"12","author":"Agar","year":"2021","journal-title":"Mol Autism"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1111\/1467-8624.00414","article-title":"Sleep, neurobehavioral functioning, and behavior problems in school-age children","volume":"73","author":"Sadeh","year":"2002","journal-title":"Child Dev"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1698","DOI":"10.1093\/sleep\/30.12.1698","article-title":"Sleep disordered breathing and daytime sleepiness are associated with poor academic performance in teenagers. A study using the Pediatric daytime sleepiness scale (PDSS)","volume":"30","author":"Perez-Chada","year":"2007","journal-title":"Sleep"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1093\/sleep\/30.9.1213","article-title":"Associations between sleep duration patterns and behavioral\/cognitive functioning at school entry","volume":"30","author":"Touchette","year":"2007","journal-title":"Sleep"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1037\/a0028204","article-title":"Sleep, cognition, and behavioral problems in school-age children: a century of research meta-analyzed","volume":"138","author":"Astill","year":"2012","journal-title":"Psychol Bull"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1093\/jpepsy\/jst033","article-title":"Manipulating sleep duration alters emotional functioning and cognitive performance in children","volume":"38","author":"Vriend","year":"2013","journal-title":"J Pediatr Psychol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"77","DOI":"10.5665\/sleep.3312","article-title":"Long-term changes in neurocognition and behavior following treatment of sleep disordered breathing in school-aged children","volume":"37","author":"Biggs","year":"2014","journal-title":"Sleep"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.1007\/s10803-016-2723-7","article-title":"Sleep and Behavioral problems in children with autism Spectrum disorder","volume":"46","author":"Mazurek","year":"2016","journal-title":"J Autism Dev Disord"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1002\/ajmg.a.38829","article-title":"Sleep disturbances in Rett syndrome: impact and management including use of sleep hygiene practices","volume":"176","author":"Boban","year":"2018","journal-title":"Am J Med Genet A"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.sleep.2018.11.021","article-title":"A review of developmental consequences of poor sleep in childhood","volume":"60","author":"Spruyt","year":"2019","journal-title":"Sleep Med"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1002\/ajmg.a.62601","article-title":"Sleep problems in fragile X syndrome: cross-sectional analysis of a large clinic-based cohort","volume":"188","author":"Budimirovic","year":"2022","journal-title":"Am J Med Genet A"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/jir.13093","article-title":"Sleep in people with and without intellectual disabilities: a systematic review and meta-analysis","volume":"68","author":"Browne","year":"2024","journal-title":"J Intellect Disabil Res"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.pediatrneurol.2024.01.004","article-title":"Sleep and the social profiles of individuals with Rett syndrome","volume":"152","author":"Zhang","year":"2024","journal-title":"Pediatr Neurol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.pediatrneurol.2021.07.009","article-title":"Evaluating sleep disturbances in children with rare genetic neurodevelopmental syndromes","volume":"123","author":"Veatch","year":"2021","journal-title":"Pediatr Neurol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1002\/ajmg.a.36058","article-title":"Angelman syndrome in Denmark. Birth incidence, genetic findings, and age at diagnosis","author":"Mertz","year":"2013","journal-title":"Am J Med Genet A"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/s41572-023-00443-4","article-title":"Imprinting disorders","volume":"9","author":"Eggermann","year":"2023","journal-title":"Nat Rev Dis Primers"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1097\/GIM.0b013e3181def138","article-title":"Clinical and genetic aspects of Angelman syndrome","volume":"12","author":"Williams","year":"2010","journal-title":"Genet Med"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.3390\/ijms27031270","article-title":"Clinical presentation, genetics, and laboratory testing with integrated genetic analysis of molecular mechanisms in Prader-Willi and Angelman syndromes: a review","volume":"27","author":"Butler","year":"2026","journal-title":"Int J Mol Sci"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1002\/ajmg.a.61382","article-title":"An overview of health issues and development in a large clinical cohort of children with Angelman syndrome","volume":"182","author":"Bindels-de Heus","year":"2020","journal-title":"Am J Med Genet A"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"3625","DOI":"10.1038\/s41380-020-0858-6","article-title":"Angelman syndrome genotypes manifest varying degrees of clinical severity and developmental impairment","volume":"26","author":"Keute","year":"2021","journal-title":"Mol Psychiatry"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"3S","DOI":"10.1097\/00019616-200010041-00002","article-title":"Prader-Willi syndrome: clinical and genetic findings","volume":"10","author":"Butler","year":"2000","journal-title":"Endocrinologist"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1002\/ajmg.a.38582","article-title":"Prader-Willi syndrome and early-onset morbid obesity NIH rare disease consortium: a review of natural history study","volume":"176","author":"Butler","year":"2018","journal-title":"Am J Med Genet A"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/s41572-024-00568-0","article-title":"Rett syndrome","volume":"10","author":"Gold","year":"2024","journal-title":"Nat Rev Dis Primers"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1002\/ana.22124","article-title":"Rett syndrome: revised diagnostic criteria and nomenclature","volume":"68","author":"Neul","year":"2010","journal-title":"Ann Neurol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/1866-1955-6-20","article-title":"Developmental delay in Rett syndrome: data from the natural history study","volume":"6","author":"Neul","year":"2014","journal-title":"J Neurodev Disord"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1352\/0895-8017(2005)110[243:SIIWAS]2.0.CO;2","article-title":"Sleep in individuals with Angelman syndrome: parent perceptions of patterns and problems","volume":"110","author":"Walz","year":"2005","journal-title":"Am J Ment Retard"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.sleep.2007.07.001","article-title":"Are there distinctive sleep problems in Angelman syndrome?","volume":"9","author":"Pelc","year":"2008","journal-title":"Sleep Med"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.smrv.2017.01.002","article-title":"Sleep in Angelman syndrome: a review of evidence","volume":"37","author":"Spruyt","year":"2018","journal-title":"Sleep Med Rev"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"13587","DOI":"10.1523\/jneurosci.2194-15.2015","article-title":"Maternal Ube3a loss disrupts sleep homeostasis but leaves circadian rhythmicity largely intact","volume":"35","author":"Ehlen","year":"2015","journal-title":"J Neurosci"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.cub.2014.12.047","article-title":"Ube3a imprinting impairs circadian robustness in Angelman syndrome models","volume":"25","author":"Shi","year":"2015","journal-title":"Curr Biol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"e12697","DOI":"10.1111\/jpi.12697","article-title":"Angelman syndrome and melatonin: what can they teach us about sleep regulation","volume":"69","author":"Buonfiglio","year":"2020","journal-title":"J Pineal Res"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1002\/ppul.10152","article-title":"Sleep and breathing in Prader-Willi syndrome","volume":"34","author":"Nixon","year":"2002","journal-title":"Pediatr Pulmonol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"4911","DOI":"10.1210\/jc.2006-0765","article-title":"Sleep-related breathing disorders in prepubertal children with Prader-Willi syndrome and effects of growth hormone treatment","volume":"91","author":"Festen","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"111","DOI":"10.5664\/jcsm.27126","article-title":"Sleepiness and sleep disordered breathing in Prader-Willi syndrome: relationship to genotype, growth hormone therapy, and body composition","volume":"4","author":"Williams","year":"2008","journal-title":"J Clin Sleep Med"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.sleep.2005.12.004","article-title":"Sleep cycling alternating pattern (CAP) expression is associated with hypersomnia and GH secretory pattern in Prader-Willi syndrome","volume":"7","author":"Priano","year":"2006","journal-title":"Sleep Med"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1097\/MCP.0b013e32833ef547","article-title":"Prader-Willi syndrome: sorting out the relationships","volume":"16","author":"Bruni","year":"2010","journal-title":"Curr Opin Pulm Med"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1515\/jpem-2019-0489","article-title":"A questionnaire study on sleep disturbances associated with Prader-Willi syndrome","volume":"33","author":"Queiroga","year":"2020","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s11910-023-01254-6","article-title":"Sleep consequences of Prader-Willi syndrome","volume":"23","author":"Itani","year":"2023","journal-title":"Curr Neurol Neurosci Rep"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/1740-3391-9-12","article-title":"Magel2, a Prader-Willi syndrome candidate gene, modulates the activities of circadian rhythm proteins in cultured cells","volume":"9","author":"Devos","year":"2011","journal-title":"J Circadian Rhythms"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"4318","DOI":"10.1093\/hmg\/ddt281","article-title":"A Prader-Willi locus lncRNA cloud modulates diurnal genes and energy expenditure","volume":"22","author":"Powell","year":"2013","journal-title":"Hum Mol Genet"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.tcb.2013.07.002","article-title":"Molecular architecture of the mammalian circadian clock","volume":"24","author":"Partch","year":"2014","journal-title":"Trends Cell Biol"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1111\/jsr.12240","article-title":"The trajectories of sleep disturbances in Rett syndrome","volume":"24","author":"Wong","year":"2015","journal-title":"J Sleep Res"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.5664\/jcsm.7974","article-title":"Sleep-disordered breathing in Pediatric patients with Rett syndrome","volume":"15","author":"Sarber","year":"2019","journal-title":"J Clin Sleep Med"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"817195","DOI":"10.3389\/fneur.2022.817195","article-title":"Sleep disorders in Rett syndrome and Rett-related disorders: a narrative review","volume":"13","author":"Tascini","year":"2022","journal-title":"Front Neurol"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"13082","DOI":"10.3390\/ijerph192013082","article-title":"Sleep respiratory disturbances in girls with Rett syndrome","volume":"19","author":"Zhang","year":"2022","journal-title":"Int J Environ Res Public Health"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1177\/0883073825134756","article-title":"Sleep problems and clinical severity in Rett syndrome","volume":"41","author":"Peters","year":"2026","journal-title":"J Child Neurol"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"2315","DOI":"10.1093\/hmg\/ddm185","article-title":"Cell-specific expression of wild-type MeCP2 in mouse models of Rett syndrome yields insight about pathogenesis","volume":"16","author":"Alvarez-Saavedra","year":"2007","journal-title":"Hum Mol Genet"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.nbd.2015.03.009","article-title":"Circadian rhythm disruption in a mouse model of Rett syndrome circadian disruption in RTT","volume":"77","author":"Li","year":"2015","journal-title":"Neurobiol Dis"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1093\/sleep\/23.8.1d","article-title":"The children's sleep habits questionnaire (CSHQ): psychometric properties of a survey instrument for school-aged children","volume":"23","author":"Owens","year":"2000","journal-title":"Sleep"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1097\/dbp.0b013e318163c39a","article-title":"The children's sleep habits questionnaire in toddlers and preschool children","volume":"29","author":"Goodlin-Jones","year":"2008","journal-title":"J Dev Behav Pediatr"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S1389-9457(99)00009-X","article-title":"Pediatric sleep questionnaire (PSQ): validity and reliability of scales for sleep-disordered breathing, snoring, sleepiness, and behavioral problems","volume":"1","author":"Chervin","year":"2000","journal-title":"Sleep Med"},{"key":"ref58","first-page":"455","article-title":"The pediatric daytime sleepiness scale (PDSS): sleep habits and school outcomes in middle-school children","volume":"26","author":"Drake","year":"2003","journal-title":"Sleep"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"101355","DOI":"10.1016\/j.smrv.2020.101355","article-title":"Diagnostic meta-analysis of the Pediatric sleep questionnaire, OSA-18, and pulse oximetry in detecting pediatric obstructive sleep apnea syndrome","volume":"54","author":"Wu","year":"2020","journal-title":"Sleep Med Rev"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1213\/ANE.0000000000002864","article-title":"Correlation coefficients: appropriate use and interpretation","volume":"126","author":"Schober","year":"2018","journal-title":"Anesth Analg"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.sleep.2017.07.014","article-title":"Sleep phenotypes in infants and toddlers with neurogenetic syndromes","volume":"38","author":"Abel","year":"2017","journal-title":"Sleep Med"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1136\/jmg.33.2.107","article-title":"Clinical features in 27 patients with Angelman syndrome resulting from DNA deletion","volume":"33","author":"Smith","year":"1996","journal-title":"J Med Genet"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1136\/archdischild-2016-311298","article-title":"Longitudinal evaluation of sleep disordered breathing in infants with Prader-Willi syndrome","volume":"102","author":"Khayat","year":"2017","journal-title":"Arch Dis Child"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s11689-023-09494-w","article-title":"Enabling endpoint development for interventional clinical trials in individuals with Angelman syndrome: a prospective, longitudinal, observational clinical study (FREESIAS)","volume":"15","author":"Tjeertes","year":"2023","journal-title":"J Neurodev Disord"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"963626","DOI":"10.3389\/fneur.2022.963626","article-title":"A meta-review of standard polysomnography parameters in Rett syndrome","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Neurol"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"20552076231191622","DOI":"10.1177\/20552076231191622","article-title":"Feasibility of wearable devices and machine learning for sleep classification in children with Rett syndrome: a pilot study","volume":"9","author":"Migovich","year":"2023","journal-title":"Digit Health"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.sleh.2023.04.001","article-title":"Performance evaluation of Fitbit charge 3 and actigraphy vs. polysomnography: sensitivity, specificity, and reliability across participants and nights","volume":"9","author":"Eylon","year":"2023","journal-title":"Sleep Health"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2026.1854819\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:40:57Z","timestamp":1784695257000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2026.1854819\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,22]]},"references-count":67,"alternative-id":["10.3389\/fneur.2026.1854819"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2026.1854819","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,22]]},"article-number":"1854819"}}