{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T19:06:06Z","timestamp":1789067166120,"version":"build-2803163510"},"reference-count":105,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>Chemotherapy-induced peripheral neuropathy (CIPN), a debilitating dose-limiting toxicity affecting 20\u201385% of cancer patients, lacks disease-modifying therapies. This review synthesizes evidence supporting acupuncture as a potential multi-target strategy against CIPN. Direct preclinical CIPN studies suggest that electroacupuncture (EA) may modulate selected neuroinflammatory and oxidative pathways, including TLR4\/NF-\u03baB signaling, TRPV1 upregulation, and spinal glial activation; proposed effects on Nav1.7\u20131.9, PGC-1\u03b1\/AMPK, or HDAC6-related microtubule stabilization remain unconfirmed. Clinically, sham-controlled trials suggest that manual acupuncture and EA may alleviate pain, sensory symptoms, and quality-of-life impairment. High response rates for auricular acupuncture derive from an uncontrolled case series, and ALTENS findings are preliminary. The MC5-A Calmare device delivers Scrambler therapy and is distinct from ALTENS and acupuncture. Combination studies suggest possible additive benefit rather than established synergy. Safety profiles are generally favorable. However, clinical translation is impeded by methodological heterogeneity, subjective \u201cDe Qi\u201d assessment, and inadequate patient stratification. Future research should focus on trials with lab markers and cost analyses to determine how well acupuncture helps people complete their treatment.<\/jats:p>","DOI":"10.3389\/fneur.2026.1855553","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:14:32Z","timestamp":1789064072000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Precision acupuncture for chemotherapy-induced peripheral neuropathy: multitarget mechanisms and integrated clinical translation framework"],"prefix":"10.3389","volume":"17","author":[{"given":"Shuo","family":"Ding","sequence":"first","affiliation":[{"name":"Heilongjiang University of Chinese Medicine","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Qi","sequence":"additional","affiliation":[{"name":"Heilongjiang University of Chinese Medicine","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Heilongjiang University of Chinese Medicine","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengdi","family":"Yu","sequence":"additional","affiliation":[{"name":"Heilongjiang University of Chinese Medicine","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsong","family":"Dang","sequence":"additional","affiliation":[{"name":"Heilongjiang University of Chinese Medicine","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongna","family":"Yin","sequence":"additional","affiliation":[{"name":"Heilongjiang University of Chinese Medicine","place":["Harbin, China"]},{"name":"The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"112671","DOI":"10.1016\/j.biopha.2022.112671","article-title":"Treatment and diagnosis of chemotherapy-induced peripheral neuropathy: an update","volume":"147","author":"Desforges","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1607102","DOI":"10.3389\/fpain.2025.1607102","article-title":"The treatment of chemotherapy-induced peripheral neuropathy: a review of current management options and a potential role for scrambler therapy","volume":"6","author":"Aboumerhi","year":"2025","journal-title":"Front Pain Res (Lausanne)"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.mcna.2018.10.006","article-title":"Peripheral neuropathy","volume":"103","author":"Barrell","year":"2019","journal-title":"Med Clin North Am"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1001\/jamaoncol.2018.6771","article-title":"Chemotherapy-induced peripheral neuropathy","volume":"5","author":"Brown","year":"2019","journal-title":"JAMA Oncol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"2461","DOI":"10.1016\/j.pain.2014.09.020","article-title":"Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: a systematic review and meta-analysis","volume":"155","author":"Seretny","year":"2014","journal-title":"Pain"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1186\/s12885-019-5302-4","article-title":"Are we mis-estimating chemotherapy-induced peripheral neuropathy? 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