{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:46:34Z","timestamp":1782279994866,"version":"3.54.5"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>M\u00e9ni\u00e8re\u2019s disease (MD) is a chronic vestibular disorder that significantly impacts patients\u2019 quality of life (QoL). However, the influence of comorbid conditions on QoL in MD patients remains inadequately explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the prevalence of comorbidities in patients with MD and analyze their impact on patients\u2019 QoL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional analysis was conducted on 473 MD patients who received treatment in our hospital. Demographic data, comorbidity information, psychological symptoms (assessed by Hospital Anxiety and Depression Scale, HAD) and QoL (evaluated by M\u00e9ni\u00e8re\u2019s disease Quality of Life Questionnaire, MDoQ) were collected. Spearman correlation analysis was used to explore the relationship between comorbidities and QoL scores, and independent-samples t-test was applied for intergroup comparison. A multiple linear regression analysis was conducted to identify comorbidities influencing MDoQ.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study included 328 females (69.3%) and 145 males (30.7%) with a mean age of 45.6\u202f\u00b1\u202f14.5\u202fyears and an average disease duration of 4.5\u202f\u00b1\u202f2.0\u202fyears. The most common comorbidities were hypertension (49.0%), sleep disorders (36.6%), and diabetes mellitus (28.8%). Clear anxiety symptoms were observed in 59.2% of subjects, whereas distinct depressive symptoms were detected in 53.9%. The mean MDoQ score was 43.62\u202f\u00b1\u202f12.50 (range: 25\u201376). Correlation analysis revealed that hypertension (\n                      <jats:italic>r<\/jats:italic>\n                      \u202f=\u202f\u22120.521,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001), diabetes mellitus (\n                      <jats:italic>r<\/jats:italic>\n                      \u202f=\u202f\u22120.459,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001), sleep disorders (\n                      <jats:italic>r<\/jats:italic>\n                      \u202f=\u202f\u22120.447,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001), anxiety (\n                      <jats:italic>r<\/jats:italic>\n                      \u202f=\u202f\u22120.438,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001) and depression (\n                      <jats:italic>r<\/jats:italic>\n                      \u202f=\u202f\u22120.391,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001) were strongly negatively correlated with MDoQ scores. Multiple linear regression analysis showed that hypertension, diabetes, sleep disorder, migraine, thyroid disease and anxiety symptoms were significant factors affecting the QoL of patients with MD (\n                      <jats:italic>F<\/jats:italic>\n                      \u202f=\u202f114.18,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Comorbidities are highly prevalent in MD patients, with hypertension, sleep disorders and diabetes mellitus being the most common. These comorbidities, together with the high incidence of anxiety and depression, significantly impair patients\u2019 QoL. Comprehensive management of MD should include systematic screening, early intervention for common comorbidities and psychological support to improve patients\u2019 clinical outcomes and QoL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1855669","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:49:37Z","timestamp":1782276577000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comorbidities and impact on quality of life in patients with M\u00e9ni\u00e8re\u2019s disease: a single-center cross-sectional study"],"prefix":"10.3389","volume":"17","author":[{"given":"Zhongbao","family":"Zhang","sequence":"first","affiliation":[{"name":"Xiaolan Clinical Institute of Shantou University Medical College","place":["Zhongshan, Guangdong Province, China"]},{"name":"Department of otolaryngology,Xiaolan People\u2019s Hospital of Zhongshan (The Fifth People\u2019s Hospital of Zhongshan)","place":["Zhongshan, Guangdong Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linna","family":"Jiao","sequence":"additional","affiliation":[{"name":"Xiaolan Clinical Institute of Shantou University Medical College","place":["Zhongshan, Guangdong Province, China"]},{"name":"Department of Neurology, Xiaolan People\u2019s Hospital of Zhongshan (The Fifth People\u2019s Hospital of Zhongshan)","place":["Zhongshan, Guangdong Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xiaolan Clinical Institute of Shantou University Medical College","place":["Zhongshan, Guangdong Province, China"]},{"name":"Department of otolaryngology,Xiaolan People\u2019s Hospital of Zhongshan (The Fifth People\u2019s Hospital of Zhongshan)","place":["Zhongshan, Guangdong Province, China"]},{"name":"Dizziness and Vertigo Treatment Center,Xiaolan People\u2019s Hospital of Zhongshan (The Fifth People\u2019s Hospital of Zhongshan)","place":["Zhongshan, Guangdong Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfeng","family":"Rong","sequence":"additional","affiliation":[{"name":"Xiaolan Clinical Institute of Shantou University Medical College","place":["Zhongshan, Guangdong Province, China"]},{"name":"Department of otolaryngology,Xiaolan People\u2019s Hospital of Zhongshan (The Fifth People\u2019s Hospital of Zhongshan)","place":["Zhongshan, Guangdong Province, China"]},{"name":"Dizziness and Vertigo Treatment Center,Xiaolan People\u2019s Hospital of Zhongshan (The Fifth People\u2019s Hospital of Zhongshan)","place":["Zhongshan, Guangdong Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuli","family":"Wang","sequence":"additional","affiliation":[{"name":"Dizziness and Vertigo Treatment Center,Xiaolan People\u2019s Hospital of Zhongshan (The Fifth People\u2019s Hospital of Zhongshan)","place":["Zhongshan, Guangdong Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Lu","sequence":"additional","affiliation":[{"name":"Xiaolan Clinical Institute of Shantou University Medical College","place":["Zhongshan, Guangdong Province, China"]},{"name":"Department of otolaryngology,Xiaolan People\u2019s Hospital of Zhongshan (The Fifth People\u2019s Hospital of Zhongshan)","place":["Zhongshan, Guangdong Province, China"]},{"name":"Dizziness and Vertigo Treatment Center,Xiaolan People\u2019s Hospital of Zhongshan (The Fifth People\u2019s Hospital of Zhongshan)","place":["Zhongshan, Guangdong Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Wang","sequence":"additional","affiliation":[{"name":"Xiaolan Clinical Institute of Shantou University Medical College","place":["Zhongshan, Guangdong Province, China"]},{"name":"Department of Neurology, Xiaolan People\u2019s Hospital of Zhongshan (The Fifth People\u2019s Hospital of Zhongshan)","place":["Zhongshan, Guangdong Province, China"]},{"name":"Dizziness and Vertigo Treatment Center,Xiaolan People\u2019s Hospital of Zhongshan (The Fifth People\u2019s Hospital of Zhongshan)","place":["Zhongshan, Guangdong Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1097\/WCO.0000000000001227","article-title":"Epidemiology and genetics of Meniere's disease","volume":"37","author":"Lopez-Escamez","year":"2024","journal-title":"Curr Opin Neurol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"103565","DOI":"10.1016\/j.amjoto.2022.103565","article-title":"Prevalence of anxiety and depression in Meniere's disease; 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