{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:04:05Z","timestamp":1789535045724,"version":"build-2803163510"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lower respiratory tract infection (LRTI) is a major cause of hospitalisation in older adults with Parkinson\u2019s disease (PD), but it remains uncertain whether PD-related measures provide clinically relevant information beyond general vulnerability and acute infection severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a single-centre retrospective cohort study of patients aged \u226565\u202fyears with neurologist-diagnosed PD who were hospitalised for LRTI between 2018 and 2025. The primary outcome was a composite of intensive care unit admission, invasive mechanical ventilation, or in-hospital death. Documented readmission to the index hospital within 90\u202fdays among survivors was analysed as a secondary exploratory outcome. Multivariable logistic and Cox regression models evaluated clinical factors associated with these outcomes. A hierarchical extension added Hoehn\u2013Yahr stage and pre-admission wheelchair- or bed-bound status to the base clinical model. Calendar-period analyses and bootstrap internal validation were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 246 patients, 62 (25.2%) experienced the composite in-hospital outcome. In the PD-specific extended model, higher Charlson Comorbidity Index (adjusted odds ratio [OR] per 1-point increase 1.19, 95% confidence interval [CI] 1.00\u20131.42), hypoxaemia (OR 2.00, 95% CI 1.01\u20133.96), serum albumin &amp;lt;35\u202fg\/L (OR 3.18, 95% CI 1.65\u20136.14), sepsis or septic shock (OR 2.41, 95% CI 1.17\u20134.98), and pre-admission wheelchair- or bed-bound status (OR 2.08, 95% CI 1.08\u20134.01) were associated with the outcome. Hoehn\u2013Yahr stage, PD duration, tube feeding, and antiparkinsonian medication burden were not independently associated. Among 228 patients discharged alive, 74 (32.5%) had a documented readmission to the index hospital. Hypoalbuminaemia (adjusted hazard ratio [HR] 1.82, 95% CI 1.12\u20132.95) and non-home discharge (HR 1.96, 95% CI 1.19\u20133.24) were among the factors associated with documented same-hospital return. Bootstrap-corrected discrimination was 0.81 for the extended logistic model and 0.70 for the Cox model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Severe in-hospital deterioration was associated mainly with general physiological vulnerability, acute infection severity, and pre-admission mobility dependence, whereas most other available PD-specific measures showed no clear independent association. These findings support integrated clinical assessment but not a validated PD-specific prediction strategy; the post-discharge analysis reflects documented return to the index hospital rather than complete population-level readmission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1861214","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:29:14Z","timestamp":1789532954000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["In-hospital outcomes and documented 90-day readmission to the index hospital in older patients with Parkinson\u2019s disease hospitalised for lower respiratory tract infection: a single-centre retrospective cohort study"],"prefix":"10.3389","volume":"17","author":[{"given":"Yue","family":"Zou","sequence":"first","affiliation":[{"name":"The Affiliated Hospital of Southwest Medical University","place":["Luzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JinRong","family":"Li","sequence":"additional","affiliation":[{"name":"The Fourth Affiliated Hospital of Southwest Medical University","place":["Meishan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SiWei","family":"Luo","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Southwest Medical University","place":["Luzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"3499","DOI":"10.3390\/ijms23073499","article-title":"Respiratory abnormalities in Parkinson's disease: what do we know from studies in humans and animal models?","volume":"23","author":"Kaczy\u0144ska","year":"2022","journal-title":"Int J Mol 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