{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T09:48:11Z","timestamp":1785836891016,"version":"3.56.0"},"reference-count":66,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>Endovascular thrombectomy (EVT) has transformed the treatment of acute ischemic stroke caused by large-vessel occlusion; however, its expanding indications require increasingly precise patient selection and procedural execution. This mini-review summarizes contemporary issues in EVT that go beyond the original early-window anterior-circulation paradigm. Current evidence supports the use of EVT for selected anterior-circulation large-vessel occlusion, late-window stroke, large-core infarction, and basilar artery occlusion, while more marginal scenarios\u2014including a very low Alberta Stroke Program Early CT Score (ASPECTS), minor stroke with large-vessel occlusion, presentations beyond 24\u202fh, prestroke disability, and medium-vessel occlusion\u2014require individualized assessment. Recent randomized trials have tempered enthusiasm for routine thrombectomy in medium-vessel occlusion, emphasizing the need to distinguish technical accessibility from meaningful clinical benefit, particularly when eloquent brain regions are involved. Procedural strategy has also shifted from simple recanalization toward high-quality, tissue-effective reperfusion, with attention to the access route, device selection, first-pass effect, reperfusion grade, tandem lesions, intracranial atherosclerotic disease, anesthesia, antithrombotic use, and blood-pressure management. Adjunctive therapies, especially intra-arterial thrombolysis after successful, incomplete, or failed reperfusion, remain promising but should be employed selectively rather than as a routine practice. Overall, the future of EVT lies in disciplined precision: selecting patients for whom reperfusion is likely to be beneficial, optimizing procedural quality, and developing adjunctive strategies that convert angiographic success into durable functional recovery.<\/jats:p>","DOI":"10.3389\/fneur.2026.1861577","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T09:35:42Z","timestamp":1785836142000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Endovascular thrombectomy for acute ischemic stroke: evolving patient selection, procedural strategies, and adjunctive therapies"],"prefix":"10.3389","volume":"17","author":[{"given":"Jie","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Shanghai Shidong Hospital of Yangpu District","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Shanghai Shidong Hospital of Yangpu District","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shepeng","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Shanghai Shidong Hospital of Yangpu District","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000513","article-title":"2026 guideline for the early Management of Patients with Acute Ischemic Stroke: A guideline from the American Heart Association\/American Stroke Association","author":"Prabhakaran","year":"2026","journal-title":"Stroke"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S1474-4422(25)00356-4","article-title":"Endovascular thrombectomy for acute stroke: evolving eligibility criteria and adjunct therapies","volume":"25","author":"Glavan","year":"2026","journal-title":"Lancet Neurol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"h4607","DOI":"10.1136\/bmj.h4607","article-title":"Around 9% of patients with ischaemic stroke are suitable for thrombectomy","volume":"351","author":"Cohen","year":"2015","journal-title":"BMJ"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1001\/jama.2018.11122","article-title":"The acute stroke care revolution: enhancing access to therapeutic advances","volume":"320","author":"Josephson","year":"2018","journal-title":"JAMA"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1161\/STROKEAHA.114.007506","article-title":"Drip and ship thrombolytic therapy for acute ischemic stroke: use, temporal trends, and outcomes","volume":"46","author":"Sheth","year":"2015","journal-title":"Stroke"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1016\/S0140-6736(16)00163-X","article-title":"Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials","volume":"387","author":"Goyal","year":"2016","journal-title":"Lancet"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1056\/NEJMoa1706442","article-title":"Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct","volume":"378","author":"Nogueira","year":"2018","journal-title":"N Engl J Med"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1056\/NEJMoa1713973","article-title":"Thrombectomy for stroke at 6 to 16 hours with selection by perfusion imaging","volume":"378","author":"Albers","year":"2018","journal-title":"N Engl J Med"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/S0140-6736(21)01341-6","article-title":"Thrombectomy for anterior circulation stroke beyond 6 h from time last known well (AURORA): a systematic review and individual patient data meta-analysis","volume":"399","author":"Jovin","year":"2022","journal-title":"Lancet"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1136\/jnis-2023-021366","article-title":"Endovascular thrombectomy for large ischemic strokes: meta-analysis of six multicenter randomized controlled trials","volume":"17","author":"Chen","year":"2025","journal-title":"J Neurointerv Surg"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1161\/STROKEAHA.125.050402","article-title":"Mechanical Thrombectomy for large ischemic stroke: A critical appraisal of evidence from 6 randomized controlled trials","volume":"56","author":"Sarraj","year":"2025","journal-title":"Stroke"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1016\/S0140-6736(00)02237-6","article-title":"Validity and reliability of a quantitative computed tomography score in predicting outcome of hyperacute stroke before thrombolytic therapy. ASPECTS study group. Alberta stroke Programme early CT score","volume":"355","author":"Barber","year":"2000","journal-title":"Lancet"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1136\/jnnp.2004.059261","article-title":"Imaging of the brain in acute ischaemic stroke: comparison of computed tomography and magnetic resonance diffusion-weighted imaging","volume":"76","author":"Barber","year":"2005","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref14","first-page":"1534","article-title":"Use of the Alberta stroke program early CT score (ASPECTS) for assessing CT scans in patients with acute stroke","volume":"22","author":"Pexman","year":"2001","journal-title":"AJNR Am J Neuroradiol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1007\/s00062-024-01414-2","article-title":"Endovascular Thrombectomy for large ischemic strokes with ASPECTS 0-2: a Meta-analysis of randomized controlled trials","volume":"34","author":"Winkelmeier","year":"2024","journal-title":"Clin Neuroradiol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1956","DOI":"10.1161\/STROKEAHA.124.047228","article-title":"Exploring the limits of endovascular therapy for large Core patients: where do we need more data?","volume":"55","author":"Albers","year":"2024","journal-title":"Stroke"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"e2304","DOI":"10.1212\/WNL.0000000000207262","article-title":"CT perfusion vs noncontrast CT for late window stroke thrombectomy: a systematic review and meta-analysis","volume":"100","author":"Kobeissi","year":"2023","journal-title":"Neurology"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1001\/jamaneurol.2021.4082","article-title":"Noncontrast computed tomography vs computed tomography perfusion or magnetic resonance imaging selection in late presentation of stroke with large-vessel occlusion","volume":"79","author":"Nguyen","year":"2022","journal-title":"JAMA Neurol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1161\/STROKEAHA.122.042203","article-title":"Effect of imaging selection paradigms on endovascular thrombectomy outcomes in patients with acute ischemic stroke","volume":"54","author":"Miao","year":"2023","journal-title":"Stroke"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1016\/S0140-6736(23)00575-5","article-title":"Endovascular treatment versus no endovascular treatment after 6-24 h in patients with ischaemic stroke and collateral flow on CT angiography (MR CLEAN-LATE) in the Netherlands: a multicentre, open-label, blinded-endpoint, randomised, controlled, phase 3 trial","volume":"401","author":"Olthuis","year":"2023","journal-title":"Lancet"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/S1474-4422(24)00228-X","article-title":"Collateral-based selection for endovascular treatment of acute ischaemic stroke in the late window (MR CLEAN-LATE): 2-year follow-up of a phase 3, multicentre, open-label, randomised controlled trial in the Netherlands","volume":"23","author":"Huijberts","year":"2024","journal-title":"Lancet Neurol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S0140-6736(24)01820-8","article-title":"Endovascular therapy for acute vertebrobasilar occlusion (VERITAS): a systematic review and individual patient data meta-analysis","volume":"405","author":"Nogueira","year":"2025","journal-title":"Lancet"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1056\/NEJMoa2206317","article-title":"Trial of endovascular treatment of acute basilar-artery occlusion","volume":"387","author":"Tao","year":"2022","journal-title":"N Engl J Med"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1056\/NEJMoa2207576","article-title":"Trial of Thrombectomy 6 to 24 hours after stroke due to basilar-artery occlusion","volume":"387","author":"Jovin","year":"2022","journal-title":"N Engl J Med"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1001\/jamaneurol.2021.0001","article-title":"Thrombectomy for primary distal posterior cerebral artery occlusion stroke: the TOPMOST study","volume":"78","author":"Meyer","year":"2021","journal-title":"JAMA Neurol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1161\/STROKEAHA.121.034960","article-title":"Predictors of functional outcome after Thrombectomy in patients with Prestroke disability in clinical practice","volume":"53","author":"Mill\u00e1n","year":"2022","journal-title":"Stroke"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1093\/cid\/cix1000","article-title":"Mechanical Thrombectomy for acute ischemic stroke secondary to infective endocarditis","volume":"66","author":"Ambrosioni","year":"2018","journal-title":"Clin Infect Dis"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"282","DOI":"10.5853\/jos.2023.00017","article-title":"Tissue clock beyond time clock: endovascular Thrombectomy for patients with large vessel occlusion stroke beyond 24 hours","volume":"25","author":"Mohamed","year":"2023","journal-title":"J Stroke"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1136\/neurintsurg-2021-018591","article-title":"Endovascular thrombectomy beyond 24 hours from ischemic stroke onset: a propensity score matched cohort study","volume":"15","author":"Dhillon","year":"2023","journal-title":"J Neurointerv Surg"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1177\/17474930231186039","article-title":"Evaluation of acute mechanical revascularization in minor stroke (NIHSS score \u22645) and large vessel occlusion: the MOSTE multicenter, randomized, clinical trial protocol","volume":"18","author":"Arquizan","year":"2023","journal-title":"Int J Stroke"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"2265","DOI":"10.1161\/STROKEAHA.123.043937","article-title":"Medical management versus endovascular treatment for large-vessel occlusion anterior circulation stroke with low NIHSS","volume":"54","author":"Safouris","year":"2023","journal-title":"Stroke"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1056\/NEJMoa2411668","article-title":"Endovascular treatment of stroke due to medium-vessel occlusion","volume":"392","author":"Goyal","year":"2025","journal-title":"N Engl J Med"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1056\/NEJMoa2408954","article-title":"Endovascular treatment for stroke due to occlusion of medium or distal vessels","volume":"392","author":"Psychogios","year":"2025","journal-title":"N Engl J Med"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1056\/NEJMe2500492","article-title":"Medium- and distal-vessel occlusion - the limit of Thrombectomy?","volume":"392","author":"Mocco","year":"2025","journal-title":"N Engl J Med"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.1161\/STROKEAHA.119.028891","article-title":"2B, 2C, or 3: what should be the angiographic target for endovascular treatment in ischemic stroke?","volume":"51","author":"LeCouffe","year":"2020","journal-title":"Stroke"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"257","DOI":"10.5797\/jnet.ra.2023-0054","article-title":"Devices and techniques","volume":"17","author":"Kaneko","year":"2023","journal-title":"J Neuroendovasc Ther"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1136\/neurintsurg-2021-017349","article-title":"Stroke thrombectomy complication management","volume":"13","author":"Pilgram-Pastor","year":"2021","journal-title":"J Neurointerv Surg"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1177\/15910199251342049","article-title":"Efficacy and safety of transradial versus transfemoral access for mechanical thrombectomy in acute ischemic stroke: a systematic review and meta-analysis","author":"Rehman","year":"2025","journal-title":"Interv Neuroradiol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1016\/S0140-6736(19)30476-3","article-title":"Thrombus aspiration or retrieval in acute ischaemic stroke","volume":"393","author":"Menon","year":"2019","journal-title":"Lancet"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"111412","DOI":"10.1016\/j.jocn.2025.111412","article-title":"Types of stent retrievers used in mechanical thrombectomy for acute ischaemic stroke: A scoping review","volume":"138","author":"Song","year":"2025","journal-title":"J Clin Neurosci"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1016\/S0140-6736(19)30297-1","article-title":"Aspiration thrombectomy versus stent retriever thrombectomy as first-line approach for large vessel occlusion (COMPASS): a multicentre, randomised, open label, blinded outcome, non-inferiority trial","volume":"393","author":"Turk","year":"2019","journal-title":"Lancet"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1001\/jama.2021.13827","article-title":"Effect of Thrombectomy with combined contact aspiration and stent retriever vs stent retriever alone on revascularization in patients with acute ischemic stroke and large vessel occlusion: the ASTER2 randomized clinical trial","volume":"326","author":"Lapergue","year":"2021","journal-title":"JAMA"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.wneu.2024.01.110","article-title":"Comparison of balloon guide catheters and standard guide catheters for acute ischemic stroke: an updated systematic review and meta-analysis","volume":"185","author":"Pederson","year":"2024","journal-title":"World Neurosurg"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1136\/neurintsurg-2020-015817","article-title":"Acute carotid stenting in patients undergoing thrombectomy: a systematic review and meta-analysis","volume":"13","author":"Dufort","year":"2021","journal-title":"J Neurointerv Surg"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"3097","DOI":"10.1161\/STROKEAHA.120.033032","article-title":"Endovascular therapy of anterior circulation tandem occlusions: pooled analysis from the TITAN and ETIS registries","volume":"52","author":"Anadani","year":"2021","journal-title":"Stroke"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1161\/STROKEAHA.124.050117","article-title":"Acute carotid stenting for tandem lesions in patients randomized to endovascular treatment with or without thrombolysis: results from the IRIS individual participant data Meta-analysis","volume":"57","author":"Cavalcante","year":"2026","journal-title":"Stroke"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1001\/jama.2022.1645","article-title":"Rescue therapy for failed mechanical Thrombectomy in acute ischemic stroke: A pooled analysis of the Society of Vascular and Interventional Neurology Registry","volume":"96","author":"Rodriguez-Calienes","year":"2024","journal-title":"Ann Neurol"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1161\/STROKEAHA.124.049038","article-title":"Outcomes of adjunct emergent stenting versus mechanical thrombectomy alone: the RESCUE-ICAS registry","volume":"56","author":"Al Kasab","year":"2025","journal-title":"Stroke"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/S1474-4422(24)00186-8","article-title":"Bailout intracranial angioplasty or stenting following thrombectomy for acute large vessel occlusion in China (ANGEL-REBOOT): a multicentre, open-label, blinded-endpoint, randomised controlled trial","volume":"23","author":"Gao","year":"2024","journal-title":"Lancet Neurol"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1016\/S0140-6736(22)00014-9","article-title":"Safety and efficacy of aspirin, unfractionated heparin, both, or neither during endovascular stroke treatment (MR CLEAN-MED): an open-label, multicentre, randomised controlled trial","volume":"399","author":"van der Steen","year":"2022","journal-title":"Lancet"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/S1474-4422(23)00076-5","article-title":"Admission systolic blood pressure and effect of endovascular treatment in patients with ischaemic stroke: an individual patient data meta-analysis","volume":"22","author":"Samuels","year":"2023","journal-title":"Lancet Neurol"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1001\/jama.2023.14588","article-title":"Blood pressure management after successful Thrombectomy","volume":"330","author":"Sarraj","year":"2023","journal-title":"JAMA"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1001\/jama.2023.14590","article-title":"Intensive vs conventional blood pressure lowering after endovascular Thrombectomy in acute ischemic stroke: the OPTIMAL-BP randomized clinical trial","volume":"330","author":"Nam","year":"2023","journal-title":"JAMA"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1016\/S0140-6736(22)01882-7","article-title":"Intensive blood pressure control after endovascular thrombectomy for acute ischaemic stroke (ENCHANTED2\/MT): a multicentre, open-label, blinded-endpoint, randomised controlled trial","volume":"400","author":"Yang","year":"2022","journal-title":"Lancet"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"e214640","DOI":"10.1212\/WNL.0000000000214640","article-title":"Optimal blood pressure after stroke thrombectomy: we are not all the same","volume":"106","author":"Hawkes","year":"2026","journal-title":"Neurology"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"e214577","DOI":"10.1212\/WNL.0000000000214577","article-title":"Autoregulation-guided blood pressure targets after stroke Thrombectomy: impact on secondary brain injury and neurologic outcomes","volume":"106","author":"Petersen","year":"2026","journal-title":"Neurology"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1161\/STROKEAHA.124.048994","article-title":"Recanalization does not always equate to reperfusion: no-reflow phenomenon after successful Thrombectomy","volume":"56","author":"Horie","year":"2025","journal-title":"Stroke"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1161\/strokeaha.124.049574","article-title":"Persistent tissue-level hypoperfusion (no-reflow) negates the clinical benefit of successful thrombectomy","volume":"56","author":"Rivet","year":"2025","journal-title":"Stroke"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1001\/jama.2022.0990","article-title":"Effect of intra-arterial alteplase vs placebo following successful thrombectomy on functional outcomes in patients with large vessel occlusion acute ischemic stroke: the CHOICE randomized clinical trial","volume":"327","author":"Ren\u00fa","year":"2022","journal-title":"JAMA"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1001\/jama.2025.14211","article-title":"Intra-arterial alteplase after successful endovascular reperfusion in acute stroke: the PEARL randomized clinical trial","volume":"334","year":"2025","journal-title":"JAMA"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1001\/jama.2024.23480","article-title":"Intra-arterial urokinase after endovascular reperfusion for acute ischemic stroke: the POST-UK randomized clinical trial","volume":"333","author":"Liu","year":"2025","journal-title":"JAMA"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1001\/jama.2024.23466","article-title":"Intra-arterial tenecteplase following endovascular reperfusion for large vessel occlusion acute ischemic stroke: the POST-TNK randomized clinical trial","volume":"333","author":"Huang","year":"2025","journal-title":"JAMA"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"e213842","DOI":"10.1212\/WNL.0000000000213842","article-title":"Intra-arterial thrombolysis following endovascular recanalization for large vessel occlusion stroke: A systematic review and Meta-analysis","volume":"105","author":"Jiang","year":"2025","journal-title":"Neurology"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"e213929","DOI":"10.1212\/WNL.0000000000213929","article-title":"Should we routinely administer intra-arterial thrombolysis after endovascular Thrombectomy for ischemic stroke from large vessel occlusion?","volume":"105","author":"England","year":"2025","journal-title":"Neurology"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"e824","DOI":"10.1212\/WNL.0000000000200775","article-title":"Normobaric hyperoxia combined with endovascular treatment for patients with acute ischemic stroke: a randomized controlled clinical trial","volume":"99","author":"Li","year":"2022","journal-title":"Neurology"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/S0140-6736(24)02809-5","article-title":"Normobaric hyperoxia combined with endovascular treatment for acute ischaemic stroke in China (OPENS-2 trial): a multicentre, randomised, single-blind, sham-controlled trial","volume":"405","author":"Li","year":"2025","journal-title":"Lancet"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2026.1861577\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T09:35:44Z","timestamp":1785836144000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2026.1861577\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,4]]},"references-count":66,"alternative-id":["10.3389\/fneur.2026.1861577"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2026.1861577","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,4]]},"article-number":"1861577"}}