{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T05:00:00Z","timestamp":1785214800554,"version":"3.55.0"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Electrodiagnostic testing is central to the evaluation of polyneuropathy, yet substantial variability exists in nerve selection and testing protocols. This study aimed to identify the minimum nerve set that provides high sensitivity and overall diagnostic accuracy while retaining adequate specificity. Testing two motor and two sensory nerves was hypothesized to be diagnostically sufficient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cross-sectional cohort study using a deidentified database from the electrophysiology laboratory at Sheba Medical Center. Patients diagnosed with polyneuropathy were compared with individuals who had normal nerve conduction studies. Groups were matched for age and sex, and patients with coexisting conditions such as mononeuropathies or polyradiculopathies were excluded. Associations between nerve conduction parameters and polyneuropathy were examined using chi-square analyses. Parameters with significant associations were entered into separate multivariable logistic regression models for sensory and motor nerves. ROC analyses evaluated individual nerves and progressively expanded nerve-testing protocols. Optimal sensitivity and specificity were determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 455 patients, 259 had polyneuropathy, yielding 91 matched patient\u2013control pairs. Binary sensory abnormalities of the sural and ulnar nerves were the strongest and most informative discriminators. Motor abnormalities were most prominent in the tibial and ulnar nerves. The initial three-nerve protocol, comprising sural sensory, tibial motor, and ulnar sensory and motor studies, achieved an AUC of 0.916, with 80.5% sensitivity and 89.6% specificity. Adding contralateral ulnar sensory testing increased the AUC only marginally to 0.923 and reduced sensitivity to 76.8%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The three-nerve protocol provided a favorable balance between sensitivity and specificity. These findings support a stepwise approach beginning with unilateral sural, tibial, and ulnar studies, followed by contralateral testing when needed to increase diagnostic confidence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1862881","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T04:25:17Z","timestamp":1785212717000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficient electrodiagnosis of polyneuropathy\u2014a targeted three-nerve conduction study protocol"],"prefix":"10.3389","volume":"17","author":[{"given":"Orit","family":"Mazza","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Loewenstein Rehabilitation Medical Center","place":["Raanana, Israel"]},{"name":"Hospital Management, Edith Wolfson Medical Center","place":["Holon, Israel"]},{"name":"Gray Faculty of Medical and Health Sciences, Tel Aviv University","place":["Tel Aviv, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyal","family":"Heled","sequence":"additional","affiliation":[{"name":"Department of Psychology, Ariel University","place":["Ariel, Israel"]},{"name":"Department of Neurological Rehabilitation, Division of Rehabilitation, The Integrated Rehabilitation Hospital, Sheba Medical Center","place":["Tel HaShomer, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Khamaisi","sequence":"additional","affiliation":[{"name":"Department of Neurological Rehabilitation, Division of Rehabilitation, The Integrated Rehabilitation Hospital, Sheba Medical Center","place":["Tel HaShomer, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itay","family":"Cohen","sequence":"additional","affiliation":[{"name":"Rutgers School of Public Health, Rutgers University","place":["Piscataway, NJ, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Zwecker","sequence":"additional","affiliation":[{"name":"Gray Faculty of Medical and Health Sciences, Tel Aviv University","place":["Tel Aviv, Israel"]},{"name":"Department of Neurological Rehabilitation, Division of Rehabilitation, The Integrated Rehabilitation Hospital, Sheba Medical Center","place":["Tel HaShomer, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"ref1","first-page":"732","article-title":"Peripheral neuropathy: evaluation and differential diagnosis","volume-title":"Am Fam Physician","author":"Castelli","year":"2020"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1212\/01.WNL.0000149522.32823.EA","article-title":"Distal symmetric polyneuropathy: a definition for clinical research: report of the American Academy of Neurology, the American Association of 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