{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T11:51:46Z","timestamp":1782906706334,"version":"3.54.5"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the dynamic changes, influencing factors, and prognostic significance of the asymmetric prominent vessel sign (APVS) in patients with atherosclerotic anterior circulation acute ischemic stroke (AIS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with atherosclerotic anterior circulation AIS who were admitted within 48\u202fh after symptom onset and had complete baseline and follow-up diffusion-weighted imaging (DWI) and susceptibility-weighted imaging (SWI) data obtained 10\u201314\u202fdays after treatment were retrospectively enrolled. Changes in APVS were evaluated. Clinical and imaging data were collected, including the degree of vascular stenosis, baseline SWI\u2013DWI mismatch, NIHSS scores before and after treatment, infarct volume, SWI-Alberta Stroke Program Early CT Score (SWI-ASPECTS), early neurological deterioration (END) within 7\u202fdays, and 90-day mRS scores. According to the difference in SWI-ASPECTS scores before and after treatment, patients were categorized into the significant APVS change group (\u22652 points) and the non-significant APVS change group (0\u20131 point). Univariate analyses were performed to preliminarily explore the factors associated with APVS changes and the relationship between APVS changes and clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 34 patients were included, among whom 11 were assigned to the significant APVS change group. After 10\u201314\u202fdays of standardized conservative medical treatment, the APVS extent remained unchanged in 38.2% of patients, decreased to varying degrees in 58.8% (including complete disappearance in 17.6%), and increased in only 2.9% of patients. Univariate analysis demonstrated that patients in the significant change group had larger baseline infarct volumes (\n                      <jats:italic>T<\/jats:italic>\n                      \u202f=\u202f\u22122.191,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.028) and post-treatment infarct volumes (\n                      <jats:italic>T<\/jats:italic>\n                      \u202f=\u202f\u22122.779,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.005), a higher proportion of severe vascular stenosis (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.009), and higher baseline SWI-ASPECTS scores (\n                      <jats:italic>T<\/jats:italic>\n                      \u202f=\u202f\u22123.117,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.002). No statistically significant differences were observed in the incidence of END or 90-day mRS scores between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Following standardized treatment for 10\u201314\u202fdays, APVS extent decreased or even disappeared in most patients, whereas persistent APVS was observed in a subset of patients. Baseline and post-treatment infarct volumes, degree of vascular stenosis, and baseline SWI-ASPECTS scores may influence APVS evolution. However, APVS changes were not significantly associated with clinical prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1868578","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T11:28:35Z","timestamp":1782905315000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Dynamic changes and associated factors of asymmetric prominent vessel sign in atherosclerotic anterior circulation acute ischemic stroke: a preliminary study"],"prefix":"10.3389","volume":"17","author":[{"given":"Wenjun","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology, Hebei Medical University Third Hospital","place":["Shijiazhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuicui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hebei Medical University Third Hospital","place":["Shijiazhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hebei Medical University Third Hospital","place":["Shijiazhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hebei Medical University Third Hospital","place":["Shijiazhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiling","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hebei Medical University Third Hospital","place":["Shijiazhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hebei Medical University Third Hospital","place":["Shijiazhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hebei Medical University Third Hospital","place":["Shijiazhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"203071","DOI":"10.1148\/radiol.2021203071","article-title":"Susceptibility-weighted imaging: technical essentials and clinical neurologic applications","volume":"299","author":"Haller","year":"2021","journal-title":"Radiology"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3389\/fneur.2021.660529","article-title":"Diffusion and susceptibility weighted imaging mismatch correlates with collateral circulation and prognosis after middle cerebral artery M1-segment occlusion","volume":"12","author":"Xu","year":"2021","journal-title":"Front 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acute ischemic stroke patients","volume":"13","author":"Huang","year":"2022","journal-title":"Front Neurol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s13244-019-0810-y","article-title":"Mapping the ischemic penumbra and predicting stroke progression in acute ischemic stroke: the overlooked role of susceptibility weighted imaging","volume":"11","author":"Darwish","year":"2020","journal-title":"Insights Imaging"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"e4526","DOI":"10.1002\/nbm.4526","article-title":"Penumbra quantification from MR SWI-DWI mismatch and its comparison with MR ASL PWI-DWI mismatch in patients with acute ischemic stroke","volume":"34","author":"Bhattacharjee","year":"2021","journal-title":"NMR Biomed"}],"container-title":["Frontiers in 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