{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T06:01:04Z","timestamp":1785391264116,"version":"3.55.0"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Reliable noninvasive assessment of intracranial pressure (ICP) remains an unmet clinical need. Wideband tympanometry (WBT), which reflects middle ear mechanics, may provide indirect information on ICP-related inner ear pressure changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine whether postural ICP variations induce measurable changes in WBT parameters in healthy adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this prospective study, 21 healthy adults (42 ears) underwent repeated WBT measurements in standing, supine, and Trendelenburg (\u221217\u00b0) positions. Five measurements were performed per ear in each position. Parameters analyzed included peak pressure (PP), peak pressure difference (\n                      <jats:italic>\u0394P<\/jats:italic>\n                      ), resonant frequency (RF), duplication frequency (DF), and absorbance-derived metrics. Statistical comparisons were performed using paired non-parametric tests with \u0160id\u00e1k correction for multiple comparisons.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 626 valid recordings were analyzed. PP and\n                      <jats:italic>\u0394P<\/jats:italic>\n                      significantly increased in the Trendelenburg position compared with standing (PP: \u221210.9\u202f\u00b1\u202f8.1 vs. 5.5\u202f\u00b1\u202f24.4 daPa,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.01;\n                      <jats:italic>\u0394P<\/jats:italic>\n                      : 90.7\u202f\u00b1\u202f42.0 vs. 105.0\u202f\u00b1\u202f51.5 daPa,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). No significant changes were observed for RF, DF, or absorbance-derived parameters. Interaural reproducibility was moderate to high for most variables but low for\n                      <jats:italic>\u0394P<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Postural changes associated with presumed ICP elevation induce measurable modifications in WBT signals, particularly PP and\n                      <jats:italic>\u0394P<\/jats:italic>\n                      . These findings support WBT as a promising noninvasive approach for detecting ICP variations. Further validation against invasive ICP monitoring is warranted.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1874870","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T05:39:02Z","timestamp":1785389942000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Wideband tympanometry as a noninvasive marker of intracranial pressure changes: a postural study in healthy adults"],"prefix":"10.3389","volume":"17","author":[{"given":"Florian","family":"Nourrisson","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Dijon University Hospital","place":["Dijon, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuan","family":"Le Van","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Dijon University Hospital","place":["Dijon, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Marzani","sequence":"additional","affiliation":[{"name":"ImViA UR 7535, Universit\u00e9 Bourgogne Europe","place":["Dijon, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Umer","sequence":"additional","affiliation":[{"name":"ImViA UR 7535, Universit\u00e9 Bourgogne Europe","place":["Dijon, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leixin","family":"Nie","sequence":"additional","affiliation":[{"name":"ImViA UR 7535, Universit\u00e9 Bourgogne Europe","place":["Dijon, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Bozorg Grayeli","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Dijon University Hospital","place":["Dijon, France"]},{"name":"ICMUB, UMR CNRS 6302, Universit\u00e9 Bourgogne Europe","place":["Dijon, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/ane.12527","article-title":"Non-invasive assessment of intracranial pressure","volume":"134","author":"Robba","year":"2016","journal-title":"Acta Neurol Scand"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s12028-015-0132-y","article-title":"Global monitoring in the neurocritical care unit","volume":"22","author":"Olson","year":"2015","journal-title":"Neurocrit Care"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1385\/NCC:4:1:008","article-title":"Impact of intracranial pressure and cerebral perfusion pressure on severe disability and mortality after head injury","volume":"4","author":"Balestreri","year":"2006","journal-title":"Neurocrit 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