{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T05:19:05Z","timestamp":1787548745228,"version":"build-2736575974"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004331","name":"Johnson & Johnson","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004331","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Balloon guide catheters (BGCs) have demonstrated benefits in mechanical thrombectomy (MT) for acute ischemic stroke (AIS), including improved recanalization rates and reduced distal embolization. The EMBOGUARD\u2122 balloon guide catheter (Johnson &amp;amp; Johnson Neurovascular, Irvine, CA) represents a novel design with enhanced flexibility and compatibility with large-bore aspiration catheters. This study aims to evaluate the safety and efficacy of the EMBOGUARD\u2122 BGC compared with non-BGC approaches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective multicenter study to analyze patients with AIS due to anterior large vessel occlusions (LVOs) who underwent MT between January 2022 and December 2024. Patients were divided into two groups: those treated with t\u263ahe EMBOGUARD\u2122 BGC and those treated without BGC. Primary outcomes included first-pass effect (FPE), successful recanalization (mTICI \u22652b), procedural time, number of passes, and distal embolization. Secondary outcomes included 90-day functional outcome (modified Rankin Scale [mRS] 0\u20132), mortality, and symptomatic intracranial hemorrhage (sICH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 178 patients were included (EMBOGUARD:\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f135, 75.8%; non-BGC:\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f43, 24.2%). The EMBOGUARD\u2122 group demonstrated comparable rates of FPE (33.3% vs. 37.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.68) and successful recanalization (86.7% vs. 86.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.92). Procedural time was significantly shorter in the EMBOGUARD\u2122 group (median 32\u202fmin vs. 49\u202fmin,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.004). Distal embolization rates were similar between groups (4.4% vs. 4.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f1.00). The EMBOGUARD\u2122 group showed significantly higher rates of favorable functional outcome at 90\u202fdays (48.6% vs. 28.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.04) and non-significantly lower 90-day mortality (13.7% vs. 16.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.6). Although favorably trending, multivariate logistic regression analysis did not confirm that EMBOGUARD\u2122 was associated with greater odds of FPE (adjusted odds ratio [aOR] 2.01, 95% confidence interval [CI] 0.65\u20136.41,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.2), mRS 0\u20132 at 90\u202fdays (aOR 1.36, 95% CI 0.35\u20135.34,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.7) or lower odds of mortality at 90\u202fdays (aOR 0.32, 95% CI 0.05\u20131.85,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.2).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The EMBOGUARD\u2122 balloon guide catheter demonstrated comparable technical efficacy with reduced procedural times and improved clinical outcomes compared with non-BGC techniques in endovascular thrombectomy for acute ischemic stroke. These findings support the use of EMBOGUARD\u2122 as a reasonable tool for flow arrest in stroke intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1875382","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T04:24:18Z","timestamp":1787545458000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Temporary flow arrest using EMBOGUARD\u2122 balloon guide catheter may improve functional outcomes in acute stroke thrombectomy: a multicenter retrospective study"],"prefix":"10.3389","volume":"17","author":[{"given":"Rami Z.","family":"Morsi","sequence":"first","affiliation":[{"name":"Department of Neurology, University of Chicago","place":["Chicago, IL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Falk","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Chicago","place":["Chicago, IL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Badillo Goicoechea","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, University of Chicago","place":["Chicago, IL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taraf","family":"Jaro","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Chicago","place":["Chicago, IL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archit B.","family":"Baskaran","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Chicago","place":["Chicago, IL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonam","family":"Thind","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Chicago","place":["Chicago, IL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Trad","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Chicago","place":["Chicago, IL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Khaldi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Wellstar Health System","place":["Marietta, GA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem","family":"El-Ghawanmeh","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Tennessee Health Science Center","place":["Memphis, TN, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violiza","family":"Inoa","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Tennessee Health Science Center","place":["Memphis, TN, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad H.","family":"AlMajali","sequence":"additional","affiliation":[{"name":"Neuroscience and Stroke Program, Bon Secours Mercy Health St Vincent Hospital","place":["Toledo, OH, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Chaudhari","sequence":"additional","affiliation":[{"name":"Neuroscience and Stroke Program, Bon Secours Mercy Health St Vincent Hospital","place":["Toledo, OH, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazan","family":"Ashouri","sequence":"additional","affiliation":[{"name":"Neuroscience and Stroke Program, Bon Secours Mercy Health St Vincent Hospital","place":["Toledo, OH, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama O.","family":"Zaidat","sequence":"additional","affiliation":[{"name":"Neuroscience and Stroke Program, Bon Secours Mercy Health St Vincent Hospital","place":["Toledo, OH, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmood","family":"Mirza","sequence":"additional","affiliation":[{"name":"Research Department, Johnson & Johnson Medtech Neurovascular","place":["Galway, Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Mehendale","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Chicago","place":["Chicago, IL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Siegler","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Chicago","place":["Chicago, IL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Mansour","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Chicago","place":["Chicago, IL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyam","family":"Prabhakaran","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Chicago","place":["Chicago, IL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tareq","family":"Kass-Hout","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Chicago","place":["Chicago, IL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1056\/NEJMoa1414905","article-title":"Randomized assessment of rapid endovascular treatment of ischemic stroke","volume":"372","author":"Goyal","year":"2015","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/S0140-6736(21)01341-6","article-title":"Thrombectomy for 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Surg."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.1016\/S0140-6736(24)02315-8","article-title":"Balloon guide catheters for endovascular thrombectomy in patients with acute ischaemic stroke due to large-vessel occlusion in China (PROTECT-MT): a multicentre, open-label, blinded-endpoint, randomised controlled trial","volume":"404","author":"Liu","year":"2024","journal-title":"Lancet"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1161\/STROKEAHA.124.049715","article-title":"Effect of proximal blood flow arrest during endovascular thrombectomy (ProFATE): a multicenter, blinded-end point, randomized clinical trial","volume":"56","author":"Dhillon","year":"2025","journal-title":"Stroke"}],"container-title":["Frontiers in 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