{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T04:31:43Z","timestamp":1786422703200,"version":"build-2736575974"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to investigate the characteristics of eye movements and their correlation with cognition in patients with cerebral small vessel disease (CSVD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a cross-sectional study enrolling a total of 120 patients with CSVD admitted to Hebei General Hospital from January 2022 to October 2023. The videonystagmography (VNG) was completed, and the Montreal Cognitive Assessment (MoCA) was used to evaluate the patients\u2019 cognitive function. Patients were stratified into mild (0), moderate (1\u20132), and severe (3\u20134) groups based on a 4-point MRI score integrating white matter hyperintensities, lacunar infarcts, enlarged perivascular spaces, and cerebral microbleeds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Decreased right saccade accuracy (OR\u202f=\u202f0.923, 95% CI: 0.890\u202f~\u202f0.959,\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u202f0.001), decreased left saccade accuracy (OR\u202f=\u202f0.938, 95% CI: 0.908\u202f~\u202f0.968,\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u202f0.001), prolonged right saccade latency (OR\u202f=\u202f1.015, 95% CI: 1.008\u202f~\u202f1.023,\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u202f0.001), and prolonged left saccade latency (OR\u202f=\u202f1.014, 95% CI: 1.007\u202f~\u202f1.022, p\u202f&amp;lt;\u202f0.001) were independently associated with increased total CSVD burden. Decreased right saccade accuracy (OR\u202f=\u202f0.924, 95% CI: 0.876\u202f~\u202f0.973,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.004), decreased left saccade accuracy (OR\u202f=\u202f0.944, 95% CI: 0.903\u202f~\u202f0.988,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.012), decreased right peak velocity (OR\u202f=\u202f0.988, 95% CI: 0.978\u202f~\u202f0.998,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.030), decreased left peak velocity (OR\u202f=\u202f0.986, 95% CI: 0.976\u202f~\u202f0.996,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.007) and increased rightward slow-phase velocity values (OR\u202f=\u202f4.668, 95% CI: 1.669\u202f~\u202f13.066,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.003) were independently associated with cognitive impairment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Eye movement characteristics in CSVD patients were significantly correlated with the total MRI load and cognitive function. This provides an important reference value for the early identification and assessment of CSVD severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1878897","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T04:20:14Z","timestamp":1786422014000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Eye movement characteristics and their correlation with cognitive function in cerebral small vessel disease"],"prefix":"10.3389","volume":"17","author":[{"given":"Fangming","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology, Hebei General Hospital","place":["Shijiazhuang, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hebei General Hospital","place":["Shijiazhuang, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hebei General Hospital","place":["Shijiazhuang, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Litao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hebei General Hospital","place":["Shijiazhuang, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.conb.2021.07.006","article-title":"Cerebral small vessel disease: a glymphopathy?","volume":"72","author":"Benveniste","year":"2022","journal-title":"Curr Opin Neurobiol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"349","DOI":"10.17219\/acem\/131216","article-title":"Cerebral small vessel disease: a review","volume":"30","author":"Chojdak-\u0141ukasiewicz","year":"2021","journal-title":"Adv Clin Exp Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"961661","DOI":"10.3389\/fnagi.2022.961661","article-title":"Cerebral small vessel disease: pathological mechanisms and potential therapeutic targets","volume":"14","author":"Gao","year":"2022","journal-title":"Front Aging Neurosci"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e140","DOI":"10.1161\/strokeaha.123.045102","article-title":"10 things you should know about cerebral small vessel disease","volume":"55","author":"Losso","year":"2024","journal-title":"Stroke"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"2347","DOI":"10.1007\/s00415-018-9077-3","article-title":"Cerebral small vessel disease: neuroimaging markers and clinical implication","volume":"266","author":"Chen","year":"2019","journal-title":"J Neurol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"4563","DOI":"10.1007\/s00415-020-10262-2","article-title":"Cognitive evaluation in cerebral small vessel disease: towards an evidence-based identification of the reference standards. 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