{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:10:49Z","timestamp":1788779449617,"version":"build-2803163510"},"reference-count":71,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Zhejiang Elite Vanguard and Leading Goose Initiative","award":["2025C02200"],"award-info":[{"award-number":["2025C02200"]}]},{"DOI":"10.13039\/501100005199","name":"Chinese Medicine Research Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2024ZL368"],"award-info":[{"award-number":["2024ZL368"]}],"id":[{"id":"10.13039\/501100005199","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Basic Scientific Research Project of Hangzhou Medical College","award":["KYQN2024002"],"award-info":[{"award-number":["KYQN2024002"]}]},{"name":"Zhejiang Provincial Rehabilitation Medicine Association Scientific Research Special Fund Project","award":["ZKKY2024009"],"award-info":[{"award-number":["ZKKY2024009"]}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>The neuroimmune response following ischemic stroke is a highly dynamic and complex process with dualistic effects. Traditional broad-spectrum anti-inflammatory strategies are limited in efficacy and may impede repair due to a lack of spatiotemporal specificity. This review systematically proposes and argues for \u201cspatiotemporally precise immune reprogramming\u201d as the core paradigm for next-generation stroke neuroimmune therapy. It critically analyzes the necessity of shifting the paradigm from systemic \u201cimmunosuppression\u201d to intralesional \u201cprecise reprogramming.\u201d The article further constructs a detailed technical roadmap to achieve this paradigm, encompassing key cellular and molecular targets, advanced delivery systems (such as targeted nanotechnology and biomaterial scaffolds), and the challenges of clinical translation. This review aims to provide a theoretical framework and future directions for developing novel therapeutic strategies that can dynamically modulate the immune microenvironment according to the pathological phase and cellular specificity of stroke to promote neural repair.<\/jats:p>","DOI":"10.3389\/fneur.2026.1884472","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:32:40Z","timestamp":1788777160000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Spatiotemporally precise immune reprogramming: a new paradigm for next-generation neuroimmune therapy in ischemic stroke"],"prefix":"10.3389","volume":"17","author":[{"given":"Lingling","family":"Tuo","sequence":"first","affiliation":[{"name":"The First People's Hospital of Xiaoshan District","place":["Hangzhou, Zhejiang, 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