{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:07:38Z","timestamp":1791518858327,"version":"4.3.4"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The diagnosis of acute central retinal artery occlusion (CRAO) and branch retinal artery occlusion (BRAO) is often delayed or missed in emergency departments (EDs) because of limited ocular funduscopic skills and lack of immediate ophthalmology access. We evaluated the clinical impact of our Eye-Stroke protocol using non-mydriatic ocular imaging (non-mydriatic fundus photography and optical coherence tomography [NMFP-OCT]) in our general ED with remote interpretation by ophthalmology on the time to diagnosis and emergent management of acute CRAO\/BRAO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective consecutive series of 100 acute CRAO\/BRAOs seen within 1\u202fweek of vision loss between June 2023 and April 2026 with NMFP-OCT in our ED.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 100 CRAO\/BRAO eyes seen within 1\u202fweek of onset, 16 (16%) had vision loss within 4.5\u202fh, 49 (49%) between 4.5 and 24\u202fh, 35 (35%) between 24\u202fh and 1\u202fweek (median times from presentation to NMFP-OCT 28.5\u202fmin [IQR, 17.75\u201357.5\u202fmin; range, 10\u2013330\u202fmin], 96\u202fmin [IQR, 51\u2013180\u202fmin; range; 9\u2013317\u202fmin], and 134\u202fmin [IQR, 96\u2013187\u202fmin; range, 30\u2013337\u202fmin], respectively). The diagnosis of CRAO\/BRAO was made from color photographs and OCT in 77\/100 eyes, from OCT only in 19\/100 eyes, and 3\/100 eyes had uninterpretable imaging. 7\/16 eyes presenting within 4.5\u202fh of vision loss received intravenous thrombolysis (median door-to-needle time, 58\u202fmin [IQR, 46\u201378.5\u202fmin; range, 41\u2013181\u202fmin]). The majority of the patients evaluated within 4.5\u202fh were self-referred to our ED, whereas the majority of the patients presenting later were referred by outside providers or transferred from other EDs. Stroke workup found a major cause of CRAO\/BRAO in 72%, and 17\/94 (18%) had concurrent cerebral infarctions on brain magnetic resonance imaging (MRI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite our Eye-Stroke protocol, facilitated by NFMP-OCT in our ED, only 16% of acute CRAO\/BRAO eyes were diagnosed early enough to be considered for intravenous (IV) thrombolysis, which was administered to only 43% of those eligible. Rapid workup found a major cause of CRAO\/BRAO in 72%, and 18% had concurrent cerebral infarctions on MRI. The main barrier to delayed diagnosis\/care was transfer from other institutions\/providers, suggesting that wide deployment of NMFP-OCT for remote diagnosis and treatment via existing telestroke networks is optimal for reducing time to diagnosis, avoiding transfers, and improving patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1885492","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:38:49Z","timestamp":1785422329000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of an eye-stroke protocol with non-mydriatic ocular imaging in an emergency department"],"prefix":"10.3389","volume":"17","author":[{"given":"Madhuri","family":"Akella","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Emory University School of Medicine","place":["Atlanta, GA, United 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States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Adamkiewicz","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Emory University School of Medicine","place":["Atlanta, GA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Trippiedi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Emory University School of Medicine","place":["Atlanta, GA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennox","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Emory University School of Medicine","place":["Atlanta, GA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Duffield","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Emory University School of Medicine","place":["Atlanta, GA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Flowers","sequence":"additional","affiliation":[{"name":"Division of Neuro-Ophthalmology, Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center","place":["Nashville, TN, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesley","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology & Visual Sciences, Dalhousie University","place":["Halifax, NS, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Keadey","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Emory University School of Medicine","place":["Atlanta, GA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Emory University School of Medicine","place":["Atlanta, GA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadi","family":"Nahab","sequence":"additional","affiliation":[{"name":"Department of Neurology, Emory University School of Medicine","place":["Atlanta, GA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy J.","family":"Newman","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Emory University School of Medicine","place":["Atlanta, GA, United States"]},{"name":"Department of Neurology, Emory University School of Medicine","place":["Atlanta, GA, United States"]},{"name":"Department of Neurological Surgery, Emory University School of Medicine","place":["Atlanta, GA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Biousse","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Emory University School of Medicine","place":["Atlanta, GA, United States"]},{"name":"Department of Neurology, Emory University School of Medicine","place":["Atlanta, GA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e282","DOI":"10.1161\/STR.0000000000000366","article-title":"Management of central retinal artery occlusion: a scientific statement from the American Heart Association","volume":"52","author":"Mac Grory","year":"2021","journal-title":"Stroke"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000513","article-title":"Guideline for the early management of patients with acute ischemic stroke: a guideline from the American Heart Association\/American Stroke Association","author":"Prabhakaran","year":"2026","journal-title":"Stroke"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/WNO.0000000000002440","article-title":"Updates 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