{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:13:01Z","timestamp":1788455581028,"version":"build-2803163510"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Post-stroke sarcopenia represents a distinct neuromuscular disorder characterized by progressive muscle loss and functional decline. Unlike age-related sarcopenia, stroke-induced muscle wasting involves specific neural mechanisms originating from central nervous system injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To systematically review the neural mechanisms underlying post-stroke sarcopenia and synthesize evidence on its clinical implications, diagnostic approaches, and therapeutic interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A mini review of the literature was conducted, synthesizing evidence from key studies addressing neural mechanisms, pathophysiology, diagnosis, or treatment of post-stroke sarcopenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Post-stroke sarcopenia affects 11%\u221267% of stroke survivors, with paretic limbs losing &amp;gt;30% muscle mass within 6 months. The pathophysiology involves a cascade from corticospinal tract damage to motor neuron degeneration, neuromuscular junction dysfunction, and muscle fiber atrophy. Key mechanisms include denervation-induced neurogenic atrophy, inflammatory dysregulation (IL-6, TNF-\u03b1, myostatin upregulation), and impaired IGF-1\/Akt\/mTOR signaling. Asymmetric muscle loss patterns distinguish this condition from primary sarcopenia. Diagnostic approaches combine imaging (DXA, BIA, CT), functional assessments (grip strength, gait speed, SPPB), and stroke-specific criteria. Multimodal interventions including neuromuscular electrical stimulation, resistance training, nutritional support, and spasticity management show promise.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Post-stroke sarcopenia is a neurogenic disorder requiring distinct diagnostic criteria and targeted interventions. Early recognition and multidisciplinary management are essential for optimizing functional recovery and reducing disability burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1885542","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:15:09Z","timestamp":1788452109000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Post-stroke sarcopenia as a neuromuscular disorder: a mini review of neural mechanisms and clinical implications"],"prefix":"10.3389","volume":"17","author":[{"given":"Lin","family":"Yang","sequence":"first","affiliation":[{"name":"Center for Rehabilitation Medicine, Rehabilitation & Sports Medicine Research Institute of Zhejiang Province, Department of Rehabilitation Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou","place":["Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen-Jun","family":"Deng","sequence":"additional","affiliation":[{"name":"Center for Rehabilitation Medicine, Rehabilitation & Sports Medicine Research Institute of Zhejiang Province, Department of Rehabilitation Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou","place":["Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S1474-4422(24)00369-7","article-title":"Global, regional, and national burden of stroke and its risk factors, 1990\u20132021: a systematic analysis for the global burden of disease study 2021","volume":"23","author":"Feigin","year":"2024","journal-title":"Lancet Neurol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"737","DOI":"10.4103\/1673-5374.382221","article-title":"Pathophysiological changes of muscle after ischemic stroke: a secondary consequence of stroke injury","volume":"19","author":"Qi","year":"2024","journal-title":"Neural Regen Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"474","DOI":"10.23736\/S1973-9087.23.07844-9","article-title":"Structural and pathophysiological muscle changes up to one year after post-stroke hemiplegia: a systematic review","volume":"59","author":"Aze","year":"2023","journal-title":"Eur J Phys Rehabil Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"e23","DOI":"10.12786\/bn.2024.17.e23","article-title":"Stroke-related sarcopenia: pathophysiology and diagnostic tools","volume":"17","author":"Chon","year":"2024","journal-title":"Brain Neurorehabil."},{"key":"B5","first-page":"119","article-title":"Sarcopenia or muscle modifications in neurologic diseases: a lexical or patophysiological difference?","volume":"49","author":"Carda","year":"2013","journal-title":"Eur J Phys Rehabil Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.ijcard.2013.10.031","article-title":"Stroke induced sarcopenia: muscle wasting and disability after stroke","volume":"170","author":"Scherbakov","year":"2013","journal-title":"Int J Cardiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"110721","DOI":"10.1016\/j.biopha.2020.110721","article-title":"New understanding of the pathogenesis and treatment of stroke-related sarcopenia","volume":"131","author":"Li","year":"2020","journal-title":"Biomed Pharmacother."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.3390\/diagnostics10121047","article-title":"Brain and muscle: how central nervous system disorders can modify the skeletal muscle","volume":"10","author":"Dalise","year":"2020","journal-title":"Diagnostics."},{"key":"B9","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1080\/10749357.2020.1783916","article-title":"Muscle changes after stroke and their impact on recovery: time for a paradigm shift? 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