{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:18:54Z","timestamp":1787750334644,"version":"build-2784847793"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Blood flow impairment due to stroke substantially causes neuronal loss, ultimately leading to cognitive decline. Dementia is a progressive neurocognitive disorder that represents a major public health challenge worldwide.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed stroke and dementia related mortality trends among older adults using the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) database from 1999 to 2024. Age-Adjusted Mortality Rates (AAMRs) per 100,000 were calculated and categorized by demographics and region. Joinpoint regression was used to estimate Annual Percent Change (APC) and Average Annual Percent Change (AAPC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 965,793 deaths due to stroke and dementia among older adults aged \u226565\u202fyears were recorded. Among the subgroups of dementia, unspecified dementia reported the greatest mortality. The AAMR observed a steep incline from 69.34 in 1999 to 99.25 in 2024. Older females observed higher overall AAMR than older males. Racially, Non-Hispanic Black population had the highest overall AAMR. Regionally, the highest overall AAMR was recorded by the Southern U. S. Despite COVID-19, the post pandemic era observed increasing mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our cohort exhibited a rise in mortality rates among elderly with stroke and dementia, underscoring the need for preventive strategies, and targeted interventions in vulnerable populations and regions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1889772","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T12:25:31Z","timestamp":1787747131000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Mortality patterns related to stroke and dementia among older adults in the U. S.: a CDC WONDER analysis from 1999 to 2024"],"prefix":"10.3389","volume":"17","author":[{"given":"Maryam","family":"Saghir","sequence":"first","affiliation":[{"name":"Department of Medicine, Jinnah Sindh Medical University","place":["Karachi, Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eshal","family":"Saghir","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dow University of Health Sciences","place":["Karachi, Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maliha","family":"Khalid","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jinnah Sindh Medical University","place":["Karachi, Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Umar","sequence":"additional","affiliation":[{"name":"Khairpur Medical College","place":["Khairpur, Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahil","family":"Jairamani","sequence":"additional","affiliation":[{"name":"Liaquat University of Medical and Health Sciences","place":["Jamshoro, Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Areej","family":"Dar","sequence":"additional","affiliation":[{"name":"Shaikh Khalifa Bin Zayed Al-Nahyan Medical & Dental College","place":["Rahim Yar Khan, Lahore, Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasiba","family":"Karimi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Bezmialem Vakif University","place":["\u0130stanbul, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Khalid","family":"Afridi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dow University of Health Sciences","place":["Karachi, Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Ijlal","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Saint Francis Medical Center","place":["Monroe, MO, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamal S.","family":"Rana","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kaiser Permanente Northern California","place":["Oakland, CA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elangovan","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Health Sciences Center, University of Louisville School of Medicine","place":["Louisville, KY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishtiaq","family":"Ahmad","sequence":"additional","affiliation":[{"name":"University of Iowa Health Care","place":["Iowa City, IA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suleman Sofian","family":"Suliman","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Surgery, National University-Sudan","place":["Khartoum, Sudan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.mpmed.2020.06.002","article-title":"Stroke: causes and clinical features","volume":"48","author":"Murphy","year":"2020","journal-title":"Medicine (Baltimore)"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1016\/j.amjmed.2018.01.022","article-title":"Dementia","volume":"131","author":"Gale","year":"2018","journal-title":"Am J Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1212\/WNL.0000000000208513","article-title":"Temporal trends of stroke and dementia-related mortality among older adults in the United States and impact of COVID-19: insight from 24-year 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