{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:00:51Z","timestamp":1790744451414,"version":"4.1.0"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"\n Background<\/jats:title>\n Patients with Parkinson\u2019s disease (PD) have a high risk of accidental injuries because motor and non-motor symptoms can impair gait, balance, cognition, and autonomic function. Acupuncture has been reported to improve gait and balance, but its association with long-term injury prevention in PD remains unclear.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We conducted a nationwide retrospective cohort study using Taiwan\u2019s National Health Insurance Research Database. Patients newly diagnosed with PD between 2001 and 2012 were followed through 2018. Propensity score matching (PSM) was used to improve comparability between patients who received acupuncture and those who did not. The PSM cohort was designated as the primary analysis, and a multivariable analysis of the full cohort was supportive. Cox proportional hazards models estimated adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Among 24,467 patients with PD, 7,830 (32.0%) received acupuncture. Accidental injuries occurred in 15.2% of patients in the acupuncture group and 17.1% of patients in the non-acupuncture group. In the primary PSM analysis, acupuncture was associated with a lower risk of hospitalization for accidental injury (aHR, 0.67; 95% CI, 0.42\u20130.85). The association was strongest for accidental falls, although no simple dose\u2013response relationship was observed across acupuncture-session categories. The supportive full-cohort analysis yielded a similar direction of association (aHR, 0.60; 95% CI, 0.39\u20130.76).<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n In this nationwide claims-based cohort, acupuncture use was associated with a lower risk of hospitalization for accidental injury among patients newly diagnosed with PD. Because residual confounding and differences in care-seeking may remain, prospective studies with clinical measures of PD severity are warranted.<\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fneur.2026.1889885","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:47:30Z","timestamp":1790743650000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Acupuncture is associated with lower accidental injury risk among patients with Parkinson\u2019s disease: a nationwide retrospective cohort study"],"prefix":"10.3389","volume":"17","author":[{"given":"Hui-Jer","family":"Chou","sequence":"first","affiliation":[{"name":"Department of Chinese Medicine, Taipei City Hospital","place":["Taipei, Taiwan"]},{"name":"Department of Physical Therapy and Assistive Technology, National Yang Ming Chiao Tung University","place":["Taipei, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Jen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chinese Medicine, Taipei City Hospital","place":["Taipei, Taiwan"]},{"name":"Institute of Traditional Medicine, School of Medicine, National Yang Ming Chiao Tung University","place":["Taipei, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun-Ku","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Chinese Medicine, Taipei City Hospital","place":["Taipei, Taiwan"]},{"name":"Institute of Traditional Medicine, School of Medicine, National Yang Ming Chiao Tung University","place":["Taipei, Taiwan"]},{"name":"Institute of Public Health, School of Medicine, National Yang Ming Chiao Tung University","place":["Taipei, Taiwan"]},{"name":"General Education Center, University of Taipei","place":["Taipei, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"596","DOI":"10.2174\/1871527320666211006142100","article-title":"Tremor and rigidity in patients with Parkinson's disease: emphasis on epidemiology, pathophysiology and contributing factors","volume":"21","author":"Kumar","year":"2022","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1002\/mds.27195","article-title":"Falls in Parkinson's disease: a complex and evolving picture","volume":"32","author":"Fasano","year":"2017","journal-title":"Mov Disord"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.cger.2019.09.002","article-title":"Orthostatic hypotension in Parkinson disease","volume":"36","author":"Palma","year":"2020","journal-title":"Clin Geriatr 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Pract"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"218","DOI":"10.3390\/jcm8020218","article-title":"Spirit-quieting traditional Chinese medicine may improve survival in prostate cancer patients with depression","volume":"8","author":"Lin","year":"2019","journal-title":"J Clin Med"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"e14468","DOI":"10.1097\/MD.0000000000014468","article-title":"Integrating traditional Chinese medicine healthcare into dementia care plan by reducing the need for special nursing care and medical expenses","volume":"98","author":"Lin","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.jep.2017.03.040","article-title":"Traditional Chinese medicine therapy reduces the catheter indwelling risk in dementia patients with difficult voiding symptoms","volume":"203","author":"Lin","year":"2017","journal-title":"J Ethnopharmacol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1177\/1545968313508470","article-title":"The relative contribution of physical and cognitive fall risk factors in people with Parkinson's disease: a large prospective cohort study","volume":"28","author":"Paul","year":"2014","journal-title":"Neurorehabil Neural Repair"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/S8756-3282(02)00848-7","article-title":"Utility of medical and drug history in fracture risk prediction among men and women","volume":"31","author":"van Staa","year":"2002","journal-title":"Bone"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.jep.2018.08.021","article-title":"Utilization of Chinese herbal medicine and its association with the risk of fracture in patients with Parkinson's disease in Taiwan","volume":"226","author":"Chen","year":"2018","journal-title":"J Ethnopharmacol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"591640","DOI":"10.3389\/fnagi.2020.591640","article-title":"Acupuncture treatment reduces incidence of Parkinson's disease in patients with depression: a population-based retrospective cohort study in Taiwan","volume":"12","author":"Huang","year":"2020","journal-title":"Front Aging Neurosci"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"247","DOI":"10.3233\/JPD-150646","article-title":"Prevalence, patterns and predictors of psychotropic polypharmacy among elderly individuals with Parkinson's disease in long term care settings in the United States","volume":"6","author":"Bhattacharjee","year":"2016","journal-title":"J Parkinsons Dis"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1125626","DOI":"10.3389\/fnins.2023.1125626","article-title":"Qualitative and quantitative meta-analysis of acupuncture effects on the motor function of Parkinson's disease patients","volume":"17","author":"Lei","year":"2023","journal-title":"Front Neurosci"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2026.1889885\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:47:36Z","timestamp":1790743656000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2026.1889885\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":15,"alternative-id":["10.3389\/fneur.2026.1889885"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2026.1889885","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]},"article-number":"1889885"}}