{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:04:41Z","timestamp":1789535081478,"version":"build-2803163510"},"reference-count":48,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To analyze the risk factors of disability in readmitted patients with recurrent stroke and construct a nomogram model, so as to provide references for clinical medical staff to formulate targeted intervention measures for stroke patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      From September 2023 to February 2025, a total of 415 readmitted patients with recurrent stroke were enrolled from the neurology departments of tertiary hospitals in Liaoning and Shanxi Provinces by convenience sampling method. Chi-square test and\n                      <jats:italic>t<\/jats:italic>\n                      -test were used for univariate analysis, and binary logistic regression analysis was performed to establish the risk prediction model. A nomogram was plotted to visualize the risk, and the model was validated via the area under the ROC curve and calibration curve.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The detection rate of disability among readmitted patients with recurrent stroke was 60%. Complicated hypertension, depressive symptoms, cognitive impairment (CI), occasional or no physical exercise were independent risk factors for disability (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05), while social support and self-efficacy were protective factors (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). The AUC value was 0.993. The calibration curve was well fitted with the ideal curve, and the clinical decision curve confirmed favorable clinical application value of the model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The constructed nomogram model presents satisfactory predictive efficiency. It can assist clinical staff in screening disability risks, and carry out targeted intervention and rehabilitation management according to relevant risk factors, so as to reduce the incidence of disability in readmitted patients with recurrent stroke.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1890175","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:33:18Z","timestamp":1789533198000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Development and validation of a disability risk prediction model in readmitted recurrent stroke patients"],"prefix":"10.3389","volume":"17","author":[{"given":"Linghui","family":"Kong","sequence":"first","affiliation":[{"name":"Linfen Central Hospital","place":["Linfen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Linfen Central Hospital","place":["Linfen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Linfen Central Hospital","place":["Linfen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Qiao","sequence":"additional","affiliation":[{"name":"Linfen Central Hospital","place":["Linfen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Feng","sequence":"additional","affiliation":[{"name":"Linfen Central Hospital","place":["Linfen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.soin.2018.06.008","article-title":"S\u00e9mantique, \u00e9pid\u00e9miologie et s\u00e9miologie des accidents vasculaires c\u00e9r\u00e9braux [Semantics, epidemiology and semiology of stroke]","volume":"63","author":"Boursin","year":"2018","journal-title":"Soins"},{"key":"ref2","first-page":"1635","article-title":"Risk factors and stroke characteristic in patients with postoperative strokes","volume-title":"J Stroke Cerebrovasc Dis","author":"Dong","year":"2017"},{"key":"ref3","first-page":"136","article-title":"Summary of China stroke prevention and control report 2020","volume":"19","author":"Wang","year":"2022","journal-title":"Chin J Cerebrovasc Dis"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/s1474-4422(21)00252-0","article-title":"Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the global burden of disease study 2019","volume":"20","year":"2021","journal-title":"Lancet Neurol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1161\/CIRCULATIONAHA.116.025250","article-title":"Prevalence, incidence, and mortality of stroke in China: results from a nationwide population-based survey of 480 687 adults","volume":"135","author":"Wang","year":"2017","journal-title":"Circulation"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"l879","DOI":"10.1136\/bmj.l879","article-title":"China's response to the rising stroke burden","volume":"364","author":"Li","year":"2019","journal-title":"BMJ"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1097\/00005650-199104000-00006","article-title":"Investigating early readmission as an indicator for quality of care studies","volume":"29","author":"Thomas","year":"1991","journal-title":"Med Care"},{"key":"ref8","first-page":"236","article-title":"Outcome after stroke in patients diseharged to independent living","volume-title":"Stroke","author":"Thomgren","year":"1990"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1177\/17474930221080904","article-title":"Reducing disability after 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ischemic stroke and construction of a prediction model","volume":"32","author":"An","year":"2011","journal-title":"Chin. J. Epidemiol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1111\/pcn.12075","article-title":"Long-term outcome in stroke survivors after discharge from a convalescent rehabilitation ward","volume":"67","author":"Mutai","year":"2013","journal-title":"Psychiatry Clin Neurosci"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1161\/STROKEAHA.110.602615","article-title":"Risk and cumulative risk of stroke recurrence: a systematic review and meta-analysis","volume":"42","author":"Mohan","year":"2011","journal-title":"Stroke"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s10072-020-04797-5","article-title":"Cumulative risk of stroke recurrence over the last 10 years: a systematic review and meta-analysis","volume":"42","author":"Lin","year":"2021","journal-title":"Neurol 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successful clinical recovery","volume":"22","author":"Jokinen","year":"2015","journal-title":"Eur J Neurol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1080\/165019702760279206","article-title":"Neglect and anosognosia after first-ever stroke: incidence and relationship to disability","volume":"34","author":"Appelros","year":"2002","journal-title":"J Rehabil Med"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.3390\/nu13051641","article-title":"Physical activity and diet quality modify the association between comorbidity and disability among stroke patients","volume":"13","author":"Nguyen","year":"2021","journal-title":"Nutrients"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.1016\/j.jstrokecerebrovasdis.2017.06.009","article-title":"Sleep duration, sedentary behavior, physical activity, and quality of life after inpatient stroke 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