{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T06:30:56Z","timestamp":1786343456265,"version":"build-2736575974"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Health-related quality-of-life (HRQOL) is a central outcome in pediatric epilepsy, yet the relative influence of disease severity versus treatment-related burden remains unclear. This study aimed to evaluate HRQOL and assess the respective contributions of clinical characteristics and treatment adverse events in children with epilepsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional analysis of 101 children enrolled in a prospective cohort in Lebanon was conducted. HRQOL was assessed using the Arabic QOLCE-55, and treatment-related adverse effects were measured using the Liverpool Adverse Events Profile (LAEP). Multivariable linear regression models, including hierarchical domain-specific analyses, were used to identify factors independently associated with HRQOL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      HRQOL was moderately reduced, with a median QOLCE-55 score of 66 (IQR 55.68\u201379.41). The physical domain was the most affected (44.44; IQR 30.55\u201359.72), while the social domain was the least impaired (82.14; IQR 67.85\u201396.42). In multivariable analysis, higher adverse-effect burden was the strongest factor associated with poorer overall HRQOL (B\u202f=\u202f\u22120.97, 95% CI \u20131.28 to \u22120.67;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001), whereas most seizure-related variables were not significant after adjustment. Inclusion of LAEP substantially improved model performance (\u0394\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      up to 0.310) and was associated with poorer HRQOL across all domains. Longer epilepsy duration remained associated with poorer physical HRQOL, and focal epilepsy with lower social and emotional scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this cohort, HRQOL was more strongly associated with treatment-related adverse effects than with most seizure-related variables. Treatment tolerability appears to represent an important and modifiable correlate of well-being. Routine assessment of adverse effects may enhance patient-centered care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1893873","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T06:15:40Z","timestamp":1786342540000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Determinants of health-related quality of life in pediatric epilepsy: the impact of treatment tolerability and epilepsy type"],"prefix":"10.3389","volume":"17","author":[{"given":"Ziad","family":"Zein","sequence":"first","affiliation":[{"name":"School of Pharmacy, Lebanese International University","place":["Beirut, Lebanon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Ayoub","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Lebanese International University","place":["Beirut, Lebanon"]},{"name":"Clinical and Epidemiological Research Laboratory, Faculty of Pharmacy, Lebanese University","place":["Beirut, Lebanon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Baydoun","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Lebanese International University","place":["Beirut, Lebanon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada","family":"El Eter","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Lebanese International University","place":["Beirut, Lebanon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahia","family":"Chahine","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Lebanese International University","place":["Beirut, Lebanon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Rahal","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Lebanese International University","place":["Beirut, Lebanon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Al-Hajje","sequence":"additional","affiliation":[{"name":"Clinical and Epidemiological Research Laboratory, Faculty of Pharmacy, Lebanese University","place":["Beirut, Lebanon"]},{"name":"INSPECT-LB (Institut National de Sant\u00e9 Publique, d'\u00c9pid\u00e9miologie Clinique et de Toxicologie-Liban)","place":["Beirut, Lebanon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Jammoul","sequence":"additional","affiliation":[{"name":"Department of Neurology, American University of Beirut Medical Center","place":["Beirut, Lebanon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelrahman","family":"Albaba","sequence":"additional","affiliation":[{"name":"Department of Neurology, American University of Beirut Medical Center","place":["Beirut, Lebanon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Jaafar","sequence":"additional","affiliation":[{"name":"Department of Neurology, American University of Beirut Medical Center","place":["Beirut, Lebanon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Beydoun","sequence":"additional","affiliation":[{"name":"Department of Neurology, American University of Beirut Medical Center","place":["Beirut, Lebanon"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1212\/WNL.0000000000003509","article-title":"Prevalence and incidence of epilepsy: a systematic review and meta-analysis of international 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