{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:50:26Z","timestamp":1791521426175,"version":"4.3.4"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Functional recovery remains heterogeneous among patients with large-vessel occlusion stroke, even after successful reperfusion. Body temperature may constitute a potentially modifiable physiological factor associated with functional outcome. In particular, whether clinical factors, including baseline stroke severity, modify this temperature-outcome association remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 219 patients with large-vessel occlusion acute ischemic stroke (LVO-AIS) who underwent EVT and achieved successful reperfusion, defined as a modified Thrombolysis in Cerebral Infarction score of 2b-3. Pre and post-EVT body temperatures were recorded. The primary outcome was favorable functional outcome, defined as a modified Rankin Scale (mRS) score of 0-2 at 90 days. Logistic regression analyses and exploratory subgroup analyses were performed to evaluate the association between body temperature and clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 219 included patients, 104 (47.5%) achieved favorable functional outcome at 90 days. Pre-EVT temperature was not significantly associated with functional outcome. In unadjusted analysis, each 1 \u00b0C increase in post-EVT temperature was associated with lower odds of favorable functional outcome (OR, 0.40; 95% CI, 0.20-0.79;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.01) and higher odds of mortality (OR, 2.02; 95% CI, 1.11-3.66;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.02). However, these associations were attenuated after multivariable adjustment (adjusted OR, 0.47; 95% CI, 0.19-1.15;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.10; adjusted OR, 1.22; 95% CI, 0.49-3.02;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.67). In exploratory subgroup analyses, a potential association between higher post-EVT temperature and lower odds of favorable outcome was observed in patients with baseline NIHSS \u2264 15 (adjusted OR, 0.29; 95% CI, 0.08-0.98;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.047), although the interaction was not statistically significant (\n                      <jats:italic>P<\/jats:italic>\n                      for interaction = 0.64).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this exploratory study, body temperature was not independently associated with functional outcome in the overall cohort. Although a potential association between higher post-EVT temperature and unfavorable outcome was observed in patients with baseline NIHSS \u2264 15, the interaction was not significant. This finding is hypothesis-generating and warrants prospective validation with pre-specified subgroup analyses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1910898","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:26:26Z","timestamp":1791519986000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Periprocedural body temperature and clinical outcomes after successful reperfusion in large vessel occlusion stroke"],"prefix":"10.3389","volume":"17","author":[{"given":"Hong-Ting","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Graduate School, Dalian Medical University","place":["Dalian, China"]},{"name":"Department of Neurology, General Hospital of Northern Theater Command","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, General Hospital of Northern Theater Command","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, General Hospital of Northern Theater Command","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gao-Peng","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Graduate School, Dalian Medical University","place":["Dalian, China"]},{"name":"Department of Neurology, General Hospital of Northern Theater Command","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, General Hospital of Northern Theater Command","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, General Hospital of Northern Theater Command","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Sheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, General Hospital of Northern Theater Command","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1177\/17474930241308142","article-title":"World Stroke Organization: Global Stroke Fact Sheet 2025","volume":"20","author":"Feigin","year":"2025","journal-title":"Int J 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