{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T04:46:43Z","timestamp":1785732403823,"version":"3.56.0"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hemorrhagic transformation (HT) is a frequent and serious complication, occurring in up to 40% of cases after endovascular treatment (EVT) for acute ischemic stroke (AIS). Inflammation has been increasingly recognized as a key factor influencing both stroke pathophysiology and post-treatment complications (such as HT) interacting with endothelial dysfunction to exacerbate vascular injury after EVT. The objective of this study is to evaluate whether systemic inflammatory status predicts HT in AIS patients, and its relationship with endothelial biomarkers in the setting of this complication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed a prospective cohort of 229 AIS patients treated with EVT. Demographic, clinical, imaging, and laboratory data were collected. Inflammatory markers included white blood cell subsets and indices such as neutrophil-to-lymphocyte ratio (NLR), neutrophil-to-platelet ratio (NPR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI). Endothelial function was assessed by flow-mediated dilation (FMD) and circulating homoarginine (HArg), asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA). The main outcome was radiological or symptomatic HT, classified according to ECASS criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      HT was observed in 92 patients (40.2%), of whom 35 (36.1% of HT and 15.3% of the total) were symptomatic. In multivariate analysis, independent predictors of HT included higher NIHSS at admission, higher plasma glucose at admission, the use of non-aspiration devices, lower pre-recanalization lymphocyte count, higher pre-recanalization SII and higher NLR levels. Among endothelial function markers, HArg correlated with inflammatory markers, ANC (\n                      <jats:italic>r<\/jats:italic>\n                      \u202f=\u202f\u22120.2) and WBC (\n                      <jats:italic>r<\/jats:italic>\n                      =\u202f\u22120.19), and was associated to PH and symptomatic HT, but not with any radiologic HT after AIS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>An altered inflammatory status prior to EVT in AIS patients is associated with an increased risk of developing HT after EVT. Additionally, endothelial dysfunction could participate in the more aggressive forms of this complication.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1913218","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T04:26:17Z","timestamp":1785731177000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Systemic inflammation and endothelial dysfunction influence the risk and severity of hemorrhagic transformation after endovascular treatment for acute ischemic stroke"],"prefix":"10.3389","volume":"17","author":[{"given":"Kattalin","family":"\u00c1lvarez-Agoues","sequence":"first","affiliation":[{"name":"Neurology Department, Donostia University Hospital","place":["San Sebastian, Spain"]},{"name":"Ictus, Biogipuzkoa Health Research Institute","place":["San Sebastian, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"de la Riva","sequence":"additional","affiliation":[{"name":"Neurology Department, Donostia University Hospital","place":["San Sebastian, Spain"]},{"name":"Ictus, Biogipuzkoa Health Research Institute","place":["San Sebastian, Spain"]},{"name":"Faculty of Health Sciences, Deusto University","place":["San Sebastian, Spain"]},{"name":"Neurosciences Department, University of the Basque Country","place":["San Sebastian, Spain"]},{"name":"RICORS-ictus, National Institute of Health Carlos III","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Rodr\u00edguez-Antig\u00fcedad","sequence":"additional","affiliation":[{"name":"Neurology Department, Hospital de la Santa Creu i Sant Pau","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Gomez","sequence":"additional","affiliation":[{"name":"Radiology Department, Donostia University Hospital","place":["San Sebastian, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gorka","family":"Arenaza-Choperena","sequence":"additional","affiliation":[{"name":"Radiology Department, Donostia University Hospital","place":["San Sebastian, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Gorostidi","sequence":"additional","affiliation":[{"name":"Genomics Platform Biogipuzkoa Research Institute","place":["San Sebastian, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noem\u00ed","family":"D\u00edez","sequence":"additional","affiliation":[{"name":"Neurology Department, Donostia University Hospital","place":["San Sebastian, Spain"]},{"name":"Ictus, Biogipuzkoa Health Research Institute","place":["San Sebastian, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"de Arce","sequence":"additional","affiliation":[{"name":"Neurology Department, Donostia University Hospital","place":["San Sebastian, Spain"]},{"name":"Ictus, Biogipuzkoa Health Research Institute","place":["San Sebastian, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maite","family":"Mart\u00ednez-Zabaleta","sequence":"additional","affiliation":[{"name":"Neurology Department, Donostia University Hospital","place":["San Sebastian, Spain"]},{"name":"Ictus, Biogipuzkoa Health Research Institute","place":["San Sebastian, Spain"]},{"name":"Neurosciences Department, University of the Basque Country","place":["San Sebastian, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E\u00f1aut","family":"Garmendia","sequence":"additional","affiliation":[{"name":"Radiology Department, Donostia University Hospital","place":["San Sebastian, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"L\u00fcttich","sequence":"additional","affiliation":[{"name":"Radiology Department, Donostia University Hospital","place":["San Sebastian, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maier","family":"Anabitarte","sequence":"additional","affiliation":[{"name":"Radiology Department, Donostia University Hospital","place":["San Sebastian, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Angel","family":"Larrea","sequence":"additional","affiliation":[{"name":"Radiology Department, Donostia University Hospital","place":["San Sebastian, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Bergareche","sequence":"additional","affiliation":[{"name":"Neurodegenerative Diseases, Biogipuzkoa Research Institute","place":["San Sebastian, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"Lopez de Munain","sequence":"additional","affiliation":[{"name":"Neurology Department, Donostia University Hospital","place":["San Sebastian, Spain"]},{"name":"Faculty of Health Sciences, Deusto University","place":["San Sebastian, Spain"]},{"name":"Neurosciences Department, University of the Basque Country","place":["San Sebastian, Spain"]},{"name":"Neurodegenerative Diseases, Biogipuzkoa Research Institute","place":["San Sebastian, Spain"]},{"name":"CIBERNED (CIBER, Institute Carlos III)","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Marta-Enguita","sequence":"additional","affiliation":[{"name":"RICORS-ictus, National Institute of Health Carlos III","place":["Madrid, Spain"]},{"name":"Valdecilla Health Research Institute, IDIVAL","place":["Santander, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1177\/17474930241308142","article-title":"World stroke organization: global stroke fact sheet 2025","volume":"20","author":"Feigin","year":"2025","journal-title":"Int J 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