{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:48:37Z","timestamp":1793216917336,"version":"4.5.0"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shenzhen Association of Traditional Chinese Medicine","award":["2024011"],"award-info":[{"award-number":["2024011"]}]},{"name":"Program of the Guangdong Provincial Administration of Traditional Chinese Medicine","award":["20252035"],"award-info":[{"award-number":["20252035"]}]},{"name":"Program of the Guangdong Provincial Administration of Traditional Chinese Medicine","award":["20251316"],"award-info":[{"award-number":["20251316"]}]},{"name":"Construction Project of Guangdong Famous Traditional Chinese Medicine Inheritance Studio"},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","award":["SZZYSM202311002"],"award-info":[{"award-number":["SZZYSM202311002"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shenzhen Excellent Scientific and Technological Innovation Talent Training Program","award":["RCBS20231211090814025"],"award-info":[{"award-number":["RCBS20231211090814025"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82305388"],"award-info":[{"award-number":["82305388"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To access the efficacy of acupuncture in improving sleep disorders in patients with amnestic Mild Cognitive Impairment (aMCI) and to investigate its mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty aMCI patients with sleep disorders and fifteen healthy controls (HC) were enrolled. Patients were randomly assigned to verum acupuncture group (VA) or sham acupuncture group (SA) for a 12-week treatment. Assessments included the Montreal Cognitive Assessment (MoCA), Pittsburgh Sleep Quality Index (PSQI), and resting-state Functional Magnetic Resonance Imaging (fMRI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At baseline, patients with aMCI exhibited aberrant brain activity in temporal, frontal, parietal, and cerebellar regions compared with HCs. After treatment, the VA group, but not the SA group, showed significant improvements in both MoCA and PSQI scores. Rs-fMRI analyses revealed significant VA-related changes in the amplitude of low-frequency fluctuation (ALFF) in the left calcarine sulcus and regional homogeneity (ReHo) in the cerebellar vermis. Changes in these imaging indicators were significantly correlated with changes in MoCA scores but not with changes in PSQI scores. Moreover, changes in MoCA scores were negatively correlated with changes in PSQI scores in the VA group (\n                      <jats:italic>r<\/jats:italic>\n                      \u202f=\u202f\u22120.536,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.039).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Acupuncture could effectively improve sleep and cognitive function in aMCI patients. The treatment-related alterations in brain function may be associated with changes in the dermatome layer and the brain-cerebellar cortex circuitry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/itmctr.ccebtcm.org.cn\/mgt\/search<\/jats:ext-link>\n                      , Identifier ITMCTR2026000708.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1913478","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:25:19Z","timestamp":1791260719000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of acupuncture for sleep disorders in amnestic mild cognitive impairment: a randomized controlled trial with fMRI"],"prefix":"10.3389","volume":"17","author":[{"given":"Di","family":"Qiu","sequence":"first","affiliation":[{"name":"Department of Acupuncture, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiyao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Acupuncture, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jikang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Acupuncture, Shenzhen Traditional Chinese Medicine Anorectal Hospital","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyao","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Acupuncture, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine","place":["Shenzhen, China"]},{"name":"Department of Acupuncture, Shenzhen Traditional Chinese Medicine Hospital","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayong","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Acupuncture, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Acupuncture, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine","place":["Shenzhen, China"]},{"name":"Department of Acupuncture, Shenzhen Traditional Chinese Medicine Hospital","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Acupuncture, The Fourth 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