{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T05:05:14Z","timestamp":1789362314211,"version":"build-2803163510"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>High-sensitivity C-reactive protein-triglyceride-glucose index (CTI) is an innovative biomarker of insulin resistance and inflammation. The objective of this study was to explore the association of high-sensitivity CTI with functional outcome in elderly patients with acute ischemic stroke (AIS) undergoing intravenous thrombolysis (IVT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Elderly AIS patients treated with IVT were enrolled in three centers. Unfavorable functional outcome was defined as Modified Rankin Scale score ranging from 3\u20136. Logistic regression models were used to calculate the odds ratio (OR) and 95% confidence interval (95% CI) for the association between high-sensitivity CTI and 3-month functional outcome. Restricted cubic splines (RCS) were performed to explore the shape of this association. Receiver operating characteristic curve was applied to evaluate the discriminatory capacity of high-sensitivity CTI. Furthermore, subgroup and sensitivity analyses were performed to examine the consistency of the observed association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 708 elderly patients were enrolled, among whom 231 (32.6%) developed unfavorable functional outcome at 3\u202fmonth follow up. In Model 3, higher continuous high sensitivity CTI levels were independently associated with 3\u202fmonth unfavorable functional outcome among elderly AIS patients receiving IVT (OR\u202f=\u202f1.64; 95% CI, 1.28\u20132.11). Taking the first quartile of high sensitivity CTI as the reference group, patients in the fourth quartile exhibited the highest risk of unfavorable functional outcome in Model 3 (OR\u202f=\u202f2.62, 95% CI, 1.48\u20134.64). RCS revealed a significant overall association between high sensitivity CTI and unfavorable functional outcome, with no statistically significant nonlinear component (\n                      <jats:italic>P<\/jats:italic>\n                      for overall &amp;lt; 0.001;\n                      <jats:italic>P<\/jats:italic>\n                      for nonlinearity\u202f=\u202f0.743). Subgroup and sensitivity analyses demonstrated consistent directions of associations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>High-sensitivity CTI was independently associated with functional outcome at 3\u202fmonths in elderly AIS patients treated with IVT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1913877","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T04:38:59Z","timestamp":1789360739000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The association of high-sensitivity C-reactive protein-triglyceride glucose index with functional outcome in elderly patients with acute ischemic stroke undergoing intravenous thrombolysis"],"prefix":"10.3389","volume":"17","author":[{"given":"Pengyu","family":"Gong","sequence":"first","affiliation":[{"name":"Department of Neurology, Affiliated Hospital of Nantong University, Medical School of Nantong University","place":["Nantong, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Haimen Hospital Affiliated to Nantong University","place":["Nantong, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaiyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nanjing First Hospital, Nanjing Medical University","place":["Nanjing, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaya","family":"Fei","sequence":"additional","affiliation":[{"name":"Department of Neurology, Affiliated Hospital of Nantong University, Medical School of Nantong University","place":["Nantong, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuye","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Affiliated Hospital of Nantong University, Medical School of Nantong University","place":["Nantong, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Affiliated Hospital of Nantong University, Medical School of Nantong University","place":["Nantong, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajie","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Affiliated Hospital of Nantong University, Medical School of Nantong University","place":["Nantong, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nantong Third People's Hospital, Affiliated Nantong Hospital 3 of Nantong University","place":["Nantong, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nanjing First Hospital, Nanjing Medical University","place":["Nanjing, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixiu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Nantong Third People's Hospital, Affiliated Nantong Hospital 3 of Nantong University","place":["Nantong, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuechun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Affiliated 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