{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T06:13:20Z","timestamp":1788416000790,"version":"build-2803163510"},"reference-count":110,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Neuropathic pain (NP) is frequently accompanied by anxiety and depression, creating a vicious cycle that impairs quality of life. Synaptic plasticity\u2014particularly long-term potentiation (LTP) and long-term depression (LTD)\u2014is increasingly recognized as a shared neural substrate linking NP to affective comorbidities. This bibliometric analysis maps the research landscape at this intersection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were retrieved from the Web of Science Core Collection (January 1, 2003, to December 31, 2025) and PubMed (2003 to 2025). After deduplication and eligibility screening, a total of 487 unique publications were identified. Citation metrics and visualization analyses were performed using VOSviewer, CiteSpace, and Bibliometrix.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Publication output has grown steadily since 2003, peaking in 2025 (43 studies). China leads in publication count (180), while the United States holds the highest citation impact (9,723 citations; 64.82 per study). Air Force Medical University and the Xi\u2019an Jiaotong University are core institutions.\n                      <jats:italic>PAIN<\/jats:italic>\n                      (24 studies) and Journal of Neuroscience (22 studies) are the leading journals. Keyword and co-citation analyses indicate that research themes have undergone a phased transition from spinal cord mechanisms to limbic circuits, and then to the comorbidity mechanisms of pain and affective comorbidities, with a gradual shift toward clinical translation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This bibliometric analysis maps a field advancing from single-region synaptic mechanisms toward multi-region circuit integration, with growing contributions from immunology. Persistent gaps in sex-difference characterization and longitudinal study design mark priorities for future investigation. As a descriptive exercise bounded by two databases, these findings should be weighed accordingly.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1916513","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:21:55Z","timestamp":1788412915000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Synaptic plasticity in affective comorbidities of neuropathic pain: a bibliometric analysis based on WoSCC and PubMed (2003\u20132025)"],"prefix":"10.3389","volume":"17","author":[{"given":"Hao","family":"Wang","sequence":"first","affiliation":[{"name":"First Clinical Medical College, Fujian University of Traditional Chinese Medicine","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanting","family":"Huang","sequence":"additional","affiliation":[{"name":"First Clinical Medical College, Fujian University of Traditional Chinese Medicine","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Lin","sequence":"additional","affiliation":[{"name":"Affiliated Rehabilitation Hospital of Fujian University of Traditional Chinese Medicine","place":["Fuzhou, China"]},{"name":"Fujian Key Laboratory of Rehabilitation Technology","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuijin","family":"Chen","sequence":"additional","affiliation":[{"name":"Affiliated Rehabilitation Hospital of Fujian University of Traditional Chinese Medicine","place":["Fuzhou, China"]},{"name":"Fujian Key Laboratory of Rehabilitation Technology","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lechun","family":"Chen","sequence":"additional","affiliation":[{"name":"Affiliated Rehabilitation Hospital of Fujian University of Traditional Chinese Medicine","place":["Fuzhou, China"]},{"name":"Fujian Key Laboratory of Rehabilitation Technology","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongye","family":"Huang","sequence":"additional","affiliation":[{"name":"Affiliated Rehabilitation Hospital of Fujian University of Traditional Chinese Medicine","place":["Fuzhou, China"]},{"name":"Fujian Key Laboratory of Rehabilitation Technology","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanzhen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Affiliated Rehabilitation Hospital of Fujian University of Traditional Chinese Medicine","place":["Fuzhou, China"]},{"name":"Fujian Key Laboratory of Rehabilitation Technology","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyu","family":"Wang","sequence":"additional","affiliation":[{"name":"First Clinical Medical College, Fujian University of Traditional Chinese Medicine","place":["Fuzhou, 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